Serum angiotensin-converting enzyme in malignant lymphomas, leukaemia and multiple myeloma

Rømer, Frode K.; Emmertsen, K

doi:10.1038/bjc.1980.232

Cited by 37 publications

(9 citation statements)

References 18 publications

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“…This is in agreement with previous reports on lung cancer. A decreased SACE level has also been found in malignant lymphoproliferative and haematological disorders in which SACE was also associated with prognosis, though not so regularly as observed in lung cancer (R0mer & Emmertsen, 1980). With regard to other lung diseases, measurement of SACE has been mostly used in sarcoidosis (Lancet, Editorial, 1980;R0mer, 1979), where high SACE is presumably due to increased formation in the monocyte macrophage-derived noncaseating epithelioid granulomas (Silverstein et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme and its association with outcome in lung cancer

Rømer¹

1981

Br J Cancer

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Summary.-Serum angiotensin-converting enzyme (SACE) in 141 patients with newly detected primary lung cancer was 22-1 + 6-1 nmol/ml/min (mean + s.d.); lower than in healthy controls (24.4 + 6-2 nmol/ml/min, P <0.02). No correlation was found between SACE and sex, age, site of cancer, histological type, or lung function.After subdivision of the patients according to increasing SACE levels: < 16.0 (mean SACE of lung cancer -s.d.), 16-0-22-0, 22-1-28-2, and >28-2 nmol/ml/min (mean SACE of lung cancer + s.d.) there was a strong association (P <0001) between SACE level and the proportion of patients who were radically operated without relapse during 8-22 months follow-up. None of 23 patients within the lowest SACE range were cured, even though 7 were referred for operation after preoperative examination. In contrast, 10/25 patients (40%O) within the highest SACE range were cured.The results suggest that low SACE is associated with poor prognosis in lung cancer, even in patients who are judged as being operable on preoperative evaluation; and measurement of preoperative SACE in lung cancer may be a useful prognostic indicator in this disorder.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme and its association with outcome in lung cancer

Rømer¹

1981

Br J Cancer

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“…Although individually low values were evenly distributed among the patients, it is known that some diseases (not included in this study) are associated with low enzyme activity, e.g. lung cancer [16] and some haematological and lymphatic malignancies [17]. A rather low SACE has also been reported in regional enteritis [22]; whereas a recent survey from our laboratory showed no difference from the reference series in yersinosis (SACE 27.7 i~ 6.5 kU/1, n = 7) or rheumatoid arthritis (SACE 22.2 f 4.6 kU/1, n = 21), these diseases being represented in this study.…”

Section: Patients Without Sarcoidosismentioning

confidence: 93%

The influence of prednisone on serum angiotensin-converting enzyme activity in patients with and without sarcoidosis

Rømer¹,

Jacobsen²

1982

Scand J Clin Lab Invest

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The influence of prednisone on S-angiotensin-converting enzyme (SACE) activity was examined by serial measurements in 20 non-sarcoidosis patients and 8 sarcoidosis patients on prednisone, compared with 26 patients and healthy controls not under treatment. All but the sarcoidosis patients had SACE within normal limits (12.0-36.8 kU/l). In the three groups initial or pretreatment SACE levels (mean +/- SD) were 20.1 +/- 5.7, 66.9 +/- 27.4 and 26.4 +/- 4.1 kU/l, respectively. Non-sarcoidosis patients on prednisone had a lower pretreatment SACE than untreated control persons, presumably due to the different diseases represented in the groups. During the observation period SACE was rather stable in untreated patients and also in the treated group as a whole. But in 12 patients with SACE greater than 18.2 kU/l (mean of reference series minus 1 SD) a significantly decreasing SACE was observed after 1 week of treatment, whereas SACE was unchanged in patients with lower pretreatment levels, suggesting that in these patients prednisone could not decrease any further a level which was already low. In sarcoidosis the elevated SACE declined, reaching a normal level after 4 weeks on prednisone. In the assay ACE was markedly inhibited by SQ 14,255 (Captopril), moderately by methylprednisolone in concentrations exceeding those generally used clinically, while no inhibition was seen using acetylsalicylic acid.

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“…Serum angiotensin I-converting enzyme is elevated in the active stages of these diseases, äs it is in hyperthyroidism (9), in chronic liver disease (10), and in diabetes mellitus with severe retinopathy (l 1). In contrast, serum angiotensin I-converting enzyme is depressed in patients with malignant lymphomas (12), leukaemia (12), multiple myeloma (12) and lung cancer (13).…”

Section: Introductionmentioning

confidence: 97%

Evaluation of a Test Kit for the Rapid and Simple Colorimetric Measurement of Angiotensin I-Converting Enzyme in Serum

Boomsma¹,

Schalekamp²

1983

CCLM

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Summary:We have evaluated a recently introduced colour test kit for the determination of serum angiotensin I-converting enzyme catalytic activity. p-Hydroxyhippuric acid, liberated from p-hydroxyhippuryl-L-histidyl-L-leucine by angiotensin I-converting enzyme, is cpnverted into a quinoneimine dye with an absorption maximum at 505 nm. The procedure shows excellent linearity over the whole ränge of catalytic activities found in serum. Intra-and inter-assay coefficients of Variation are 2-5 and 7-10% respectively. Correlation with a modified Cushman-Cheung ((1971) Biochem. Pharmacol. 20, 1637-1648) method currently used in our laboratory is good, with r = 0.985 and a regression equation of y (colour kit) = 0.423 (CushmanCheung) + 0.765. Haemoglobin, lipids, bilirubin and prednisone do not interfere but uric acid in concentrations higher than 600 / does. No extraction step is required. The assay is very rapid, and more than twenty samples can be determined in an hour. Bewertende Prüfung eines Testbestecks zur schnellen und einfachen kolorimetrischen Bestimmung von Angiotensin I-Converting Enzyme im Serum

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Serum angiotensin-converting enzyme in malignant lymphomas, leukaemia and multiple myeloma

Cited by 37 publications

References 18 publications

Angiotensin-converting enzyme and its association with outcome in lung cancer

Angiotensin-converting enzyme and its association with outcome in lung cancer

The influence of prednisone on serum angiotensin-converting enzyme activity in patients with and without sarcoidosis

Evaluation of a Test Kit for the Rapid and Simple Colorimetric Measurement of Angiotensin I-Converting Enzyme in Serum

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