Serum ANGPTL4 and SIRT1 factor levels and the Carotid Atherosclerotic plaque stability relationship analysis

Juhai  Chen,; Jiajing Li,; Yiyi Wang,; Zhemei Zhang,; Hui Yang,; Zhonglian Li,; Tianhui Wang,; Tiecheng Peng,; Xiangang Mo,; Fengyan Xu,

doi:10.14715/cmb/2023.69.9.9

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2024

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Cited by 2 publications

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“…Studies on apoE−/− mice have demonstrated that activating SIRT1 reduces plaque formation in atherosclerosis [ 3 ]. Recently, a study on human serum found that SIRT1 is related to the formation and stability of carotid plaques [ 21 ]. Therefore, SIRT1 may be a new target for the clinical prevention and treatment of atherosclerosis [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

Zhou,

Shi,

Xie

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

Zhou,

Shi,

Xie

et al. 2024

Heliyon

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SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Salvatori,

Magno,

Ceccarini

et al. 2024

IJMS

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Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokine profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone deacetylases linked to fat metabolism. SIRT1 plays a critical role in metabolic health by deacetylating target proteins in tissue types including liver, muscle, and adipose. Circulating SIRT1 levels have been found to be reduced in obesity and increased in anorexia nervosa and patients experiencing weight loss. We evaluated circulating SIRT1 levels in relation to fat levels in 32 lipodystrophic patients affected by congenital or acquired LDs compared to non-LD subjects (24 with anorexia nervosa, 22 normal weight, and 24 with obesity). SIRT1 serum levels were higher in LDs than normal weight subjects (mean ± SEM 4.18 ± 0.48 vs. 2.59 ± 0.20 ng/mL) and subjects with obesity (1.7 ± 0.39 ng/mL), whereas they were close to those measured in anorexia nervosa (3.44 ± 0.46 ng/mL). Our findings show that within the LD group, there was no relationship between SIRT1 levels and the amount of body fat. The mechanisms responsible for secretion and regulation of SIRT1 in LD deserve further investigation.

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Serum ANGPTL4 and SIRT1 factor levels and the Carotid Atherosclerotic plaque stability relationship analysis

Cited by 2 publications

References 20 publications

Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

Ginsenoside Rb1 prevents age-related endothelial senescence by modulating SIRT1/caveolin-1/enos signaling pathway

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

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