Serum anti‐immunoglobulins in psoriatic arthritis as compared with rheumatoid arthritis

Tapanes, F J; Rawson, Arnold J.; Hollander, Joseph Lee

doi:10.1002/art.1780150204

Cited by 29 publications

(13 citation statements)

References 7 publications

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“…Likewise, we were unable to demonstrate antiglobulin activity in serum reported by G uilhou et al [4], Tapanes et al [15] also failed to detect such an activity, whereas other workers [2, 4, 5] using immunoadsorption [16] or indirect IF techniques [12] have been successful in demonstrating antiglo bulin factor in sera from patients with psoriasis. Indeed, the results appear to vary depending upon the substrate and the technique used.…”

Section: Commentcontrasting

confidence: 42%

Immunological Studies in Psoriasis

T¹,

Sehgal²,

Sengupta³

et al. 1978

Dermatology

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The mean values of serum immunoglobulins A, G, M and D levels in 42 psoriasis patients showed no significant difference from those of control subjects. Analysis of the same sera for the presence of antiglobulin antibodies also yielded negative results. Antinuclear factor could be demonstrated in only 4.8% of the cases. The possibility that serum antiglobulins get drained into the lesions making their detection in the serum difficult, is supported by our preliminary findings of focal deposition in the stratum corneum of immune complexes of IgG, IgM and complement in tissue sections of psoriatic lesions from these patients.

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Section: Commentcontrasting

confidence: 42%

Immunological Studies in Psoriasis

T¹,

Sehgal²,

Sengupta³

et al. 1978

Dermatology

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“…and IgG with antigamma globulin activity was subsequently demonstrated in such complexes (6,7). Thereafter IgG rheumatoid factor (IgG RF) was found in serum from rheumatoid patients of both the adult (8)(9)(10)(11)(12) and juvenile (13) varieties by a number of techniques, In rheumatoid synovial fluids aggregates of IgG capable of reacting with IgM RF have been demonstrated (14,15). These represent immune complexes containing IgG RF (16,17).…”

mentioning

confidence: 99%

IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis

Theofilopoulos

Burtonboy

LoSpalluto

et al. 1974

Arthritis & Rheumatism

116

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The occurrence of lgG rheumatoid factor (IgG RF) and low molecular weight IgM (7s IgM) has been studied in the sera of rheumatoid patients with and without vasculitis. lgG RF was found in 67% of patients with vasculitis and in only 9% of patients without vasculitis. 7s IgM was found in 80% of patients with rheumatoid vasculitis and only 18% of patients without vasculitis. Both IgG RF and 7s IgM occurred simultaneously in 60% of patients with vasculitis and 6% of patients without vasculitis. Techniques for demonstrating lgG RF and 7s IgM in serum are described. The findings reported suggest that immune complexes containing lgG RF and possibly low-molecular weight lgM may be involved in the pathogenesis of rheumatoid vasculitis.

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“…Grundlage für die Bestimmung vom klassischen IgM-Rf mit den konventionellen Agglutinationstechniken (23,24) und von IgG-, IgA-, IgM-und IgE-Antiglobulinen mit immunadsorptiven (15,33,43,44) und radioaktiven Bestimmungsverfahren (31,32,45) (35) in modifizierter Form durchgeführt. Um zu vermeiden, daß bei einer zu langen Einwirkungszeit von Papain Fcy'-Subfragmente entstehen (46), wurde die von diesen Autoren (35) angegebene Papain-Konzentration und -Eihwirkungszeit übernommen.…”

Section: Diskussionunclassified

“…Ähnliche Befunde erhielten andere Autoren miteinemRadioimmunoassay und KaninchenIgG (32, 33) als Antigen sowie mit einer Immunadsorptionstechnik und Pferde-IgG als Antigen (15,33). Die Ergebnisse der vorliegenden Arbeit bestätigen Untersuchungen, in denen humanes IgG als Antigen verwendet wurde (43,44). Palosuo und Milgrom (61), die mit einem Immunkomplex, bestehend aus humanem Serumalbumin (HSA) und Ziegen-anti-HSAAntiserum, als Antigen arbeiteten, fanden dagegen keine erhöhten IgG-Antiglobuline bei Patienten mit seronegativer cP, wohl aber bei der Mehrzahl der Patienten mit seropositiver cP und relativ oft bei gesunden Blutspendern.…”

Section: Diskussionunclassified

Bestimmung von Serum Fcγ-Antiglobulinen bei Patienten mit chronischer Polyarthritis und systemischem Lupus erythematodes mit einem Enzymimmunotest (ELISA)

Fink¹,

Peiler²,

Deicher³

1983

LaboratoriumsMedizin

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Erythematosus by . Serum Fcy-antiglobulins were measured by use of a sandwhich antibody type ELISA. As solid phase antigen served Fey-material. It was obtained after papain cleavage of human IgG and combined affinity-and gel chromatography using Protein A-Sepharose CL-4B "and Sephadex G-150 columns. Serum Fcy-antiglobulins bound to the coated solid phase were detected photometrically by peroxidase-labelled rabbit anti-human-kappa I light chain antibodies. In sera from 29 patients with seropositive and 20 patients with seronegative rheumatoid arthritis (RA) significantly (p< 0.0005) increased serum Fcy-antiglobulin. levels compared to 41 healthy blood donors were found. No significant (p > 0.1) difference with regard to the amount of serum F.cy-antiglobulins was observed between the two RA-subgroups. Compared to the reference range sera from 19 patients with systemic lupus erythematosus (SLE) contained to a major extent no Fcy-antiglobulins.Â weak correlation was noticed between serum Fcy-antiglobulins and l g M-rheumatoid factor titers for patients with RA (r: 0.82) and SLE (r:,0.79). Neither for RA patients nor for SLE patients a correlation was found between serum Fcy-antiglobulins and antinuclear factors, anti-DNS-antibodies, circulating immune complexes and total t^aemolytic complement (CH50) activity.

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Serum anti‐immunoglobulins in psoriatic arthritis as compared with rheumatoid arthritis

Cited by 29 publications

References 7 publications

Immunological Studies in Psoriasis

Immunological Studies in Psoriasis

IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis

Bestimmung von Serum Fcγ-Antiglobulinen bei Patienten mit chronischer Polyarthritis und systemischem Lupus erythematodes mit einem Enzymimmunotest (ELISA)

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