Serum Anti- Mullerian hormone levels in multiple sclerosis; a multicenter case-control study

Mehrpour, Masoud; Taherian, Fatemeh; Arfa-Fatollahkhani, Paria; Moghadasi, Abdorreza Naser; Mokhtar, Sara; Keivani, Hosein

doi:10.14735/amcsnn2018199

Cited by 1 publication

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“…Graves et al 16 observed and association between AMH levels and clinical and radiological MS severity. In contrast with the latter, Mehrpour et al 26 observed no influence of disease duration on AMH levels and no association between Expanded Disability Status Scale (EDSS) and AMH. Sadeghpour et al 17 observed no association with EDSS at diagnosis and AMH levels in women with RRMS, although their results showed a trend towards it.…”

Section: Discussionmentioning

confidence: 92%

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Ovarian reserve in patients with multiple sclerosis: A systematic review and meta‐analysis

Carbone

Girolamo

Conforti

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo summarize recent evidence about ovarian reserve markers in women affected by multiple sclerosis (MS) compared with healthy controls, as women with MS seem to be characterized by lower anti‐Müllerian hormone (AMH) levels.MethodsThe research was conducted using PubMed (MEDLINE), Scopus, ClinicalTrial.gov, OVID and Cochrane Library from inception of each database to June 30, 2022. Studies comparing ovarian reserve markers between women with MS and healthy controls were considered eligible for inclusion. The primary outcome was serum AMH (ng/mL) levels. Results were reported as pooled odds ratio (OR) for categorical outcomes and as mean difference (MD) for continuous variables, with their 95% confidence intervals (CIs). The random effect model of DerSimonian and Laird was adopted for all analyses. A P‐value less than 0.05 was considered significant.ResultsSerum AMH circulating levels were not significantly different (MD −0.25, 95% CI −0.83 to 0.32; P = 0.390), as well as blood levels of follicle‐stimulating hormone or ovarian volume. However, antral follicle count (AFC) and estradiol blood levels were significantly lower, and luteinizing hormone (LH) levels were significantly higher in women with MS than in controls.ConclusionA significant difference in AFC, estradiol and LH levels was observed, but not for AMH levels.

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Section: Discussionmentioning

confidence: 92%

“…A total of 32 articles were identified; of these, seven were assessed with respect to their eligibility for inclusion; finally, six studies 13,14,16,17,25,26 were included in the systematic review (Tables 1 and 2; Figure 1). Included studies were retrospective or prospective case-control series.…”

Section: Re Sultsmentioning

confidence: 99%