Serum anti-Müllerian hormone levels in women are unstable in the postpartum period but return to normal within 5 months: a longitudinal study

Pankhurst, Michael W.; Kat, Annelien C de; Jones, Stephanie; Broekmans, Frank J.; Wheeler, Benjamin J

doi:10.1007/s12020-020-02491-2

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…This finding may suggest that the initial steep decline in AMH levels had already begun for women in our cohort whose 1st AMH measurement was taken at 10-13 weeks gestation. Some studies have longitudinally evaluated serum AMH levels from the 1 st to the 3 rd trimester of pregnancy, with AMH levels declining by up to 64.9% over this time, implying that AMH continues to decline into the 3 rd trimester (Pankhurst et al, 2021, Villarroel et al, 2018, Nelson et al, 2010. Unfortunately, this could not be ascertained in our study.…”

Section: Discussionmentioning

confidence: 77%

Serum anti-Müllerian hormone (AMH) concentration during pregnancy: a longitudinal study

McCredie

McShane

et al. 2023

Reproduction and Fertility

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A prospective longitudinal cohort study aimed to longitudinally examine the kinetics of Anti-müllerian hormone (AMH) during the first two trimesters of pregnancy. Pregnant women with stored 1st trimester serum samples were recruited at 24-28 weeks gestation during their gestational diabetes testing, where they provided an additional serum sample. The samples were analysed for AMH, oestradiol and progesterone concentrations. A decrease in serum AMH was observed in 40 out of 45 (88.9%) (95% CI 75.9% to 96.3%) of the participants in this study. The median serum AMH concentration was 10.9 pmol/L in the 1st trimester and 6.5 pmol/L during the 2nd trimester, with a significantly different distribution of the values between the 1st and the 2nd trimester AMH samples (p<0.001). The median percentage of AMH difference of -39.8%. This study demonstrated a significant decrease in serum AMH levels from the 1st to the 2nd trimester of pregnancy. The absolute decrease in AMH levels seems to be positively associated with 1st trimester AMH levels, whereas the percentage of AMH difference is not. Further studies are required to elucidate the potential physiological mechanisms of this finding.

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Section: Discussionmentioning

confidence: 77%

Serum anti-Müllerian hormone (AMH) concentration during pregnancy: a longitudinal study

McCredie

McShane

et al. 2023

Reproduction and Fertility

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“…It is well known that AMH level decreases during gestation ( Lutterodt et al , 2009 ; Nelson et al , 2010 ), a physiological situation of ovarian suppression, with a maximal decrease observed in the third trimester of pregnancy, followed by a gradual increase of AMH levels after delivery to return to pre-pregnancy values ( Pankhurst et al , 2016 , 2021 ; McCredie et al , 2017 ). In agreement with previous longitudinal studies in healthy women ( Nelson et al , 2010 ; Köninger et al , 2015 ; Pankhurst et al , 2016 ), we observed a progressive decline in circulating AMH during pregnancy in control women.…”

Section: Discussionmentioning

confidence: 99%

Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy

et al. 2023

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STUDY QUESTION What are the changes in serum concentration of total and cleaved anti-Muüllerian hormone (AMH) molecular forms and of androgens before and throughout pregnancy in women with and without polycystic ovary syndrome (PCOS) in a longitudinal follow-up investigation? SUMMARY ANSWER Serum levels of total and cleaved AMH are higher from preconception to the third trimester of pregnancy in women with PCOS as compared to controls, whereas testosterone and androstenedione levels are higher in women with PCOS than in control women before pregnancy and during the second and third trimester of pregnancy. WHAT IS KNOWN ALREADY Cross-sectional or partial longitudinal studies have shown higher AMH and androgen levels in pregnant women with PCOS as compared with non-PCOS women. To date, no complete longitudinal dynamic monitoring of the circulating forms of AMH and androgens from pre-conception to the third trimester of pregnancy have compared women with and without PCOS. STUDY DESIGN, SIZE, DURATION This systematic prospective quarterly longitudinal monocentric study was a comparative follow-up of 30 women with PCOS and 29 controls before and during pregnancy from April 2019 to July 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS Women aged 18–43 years with a pre-conception measurement of AMH were included during the first trimester of a singleton pregnancy. The PCOS group was defined according to the Rotterdam diagnostic criteria. The control group patients included in the study had normal ovarian reserves. Circulating total and cleaved AMH, and serum estradiol, LH, and androgen levels were measured during the first, second, and third trimester of pregnancy in all study participants. MAIN RESULTS AND THE ROLE OF CHANCE Before pregnancy, patients with PCOS had higher levels of AMH than controls. The total and cleaved AMH forms were significantly higher in women with PCOS than controls from pre-conception to the third trimester of pregnancy (all P < 0.001). Androgens (total testosterone and androstenedione) were higher in women with PCOS than controls from mid-pregnancy onwards. LIMITATIONS, REASONS FOR CAUTION Our control population was a population of infertile women with no ovarian problems but most of them had undergone ART treatments to achieve pregnancy. WIDER IMPLICATIONS OF THE FINDINGS These results strengthen the hypothesis that gestational hyperandrogenism as well as exposure to elevated AMH levels in utero could be driving forces predisposing female progeny to develop PCOS. STUDY FUNDING/COMPETING INTEREST(S) Funding was provided by INSERM, France (grant number U1172) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program, ERC-2016-CoG to P.G. grant agreement n° 725149/REPRODAMH. The authors have nothing to declare. TRIAL REGISTRATION NUMBER NCT03483792

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Extended fertility at highly advanced reproductive age is not related to anti-Müllerian hormone concentrations

Rotshenker-Olshinka

Michaeli

Srebnik

et al. 2022

Reproductive BioMedicine Online

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Serum anti-Müllerian hormone levels in women are unstable in the postpartum period but return to normal within 5 months: a longitudinal study

Cited by 5 publications

References 35 publications

Serum anti-Müllerian hormone (AMH) concentration during pregnancy: a longitudinal study

Serum anti-Müllerian hormone (AMH) concentration during pregnancy: a longitudinal study

Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy

Extended fertility at highly advanced reproductive age is not related to anti-Müllerian hormone concentrations

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