Serum antibodies and loss of periodontal bone in patients with rheumatoid arthritis

Abstract

Tolo K and Jorkjend L: Serum antibodies and loss of periodontal bone in patients with rheumatoid arthritis. J Clin Periodontol 1990; 17: 288-291. Abstract. The number of teeth, % of alveolar bone loss, serum IgG, and serum antibodies to Bacteroides gingivalis, Capnocytophaga ochracea and Eubacterium saburreum were recorded in 37 patients diagnosed with rheumatoid arthritis (RA) and in an age-and sex-matched control group of 37 individuals free from RA. The RA group had a significantly increased loss of teeth and loss of alveolar bone compared to the control group. The RA patients also had a significantly increased level of serum IgG. In the total material, 26% of the variation in loss of alveolar bone was accounted for by age, diagnosis of rheumatoid arthritis, and levels of antibodies against B. gingivalis and E. saburreum. In the RA group, 48% of this variation was accounted for by age, total serum IgG and IgG antibodies to B. gingivalis and E. saburreum.

Proinflammatory and Anti‐Inflammatory Cytokines in Gingival Crevicular Fluid and Serum of Patients With Rheumatoid Arthritis and Patients With Chronic Periodontitis

“…RA and CP have remarkably similar pathobiology 9,12,35 . Studies evaluating the association between CP and RA were conducted, but the findings were inconsistent 8,23,34,36‐40 . These differences may be arising from different study designs and different disease classifications.…”

Is there a relationship between juvenile idiopathic arthritis and periodontitis?

“…Elevated serum concentrations for immunoglobulins could be an indication of an increased humoral response to arthritogenic antigens. Tolo & Jorkjend (1990) reported that the total serum IgG as well as specific IgG antibodies to Bacteroides gingivalis and Eubacterium saburreum influenced the degree of alveolar bone loss in patients with RA. In the present study, there was no significant difference between the means of SBI and CAL depending on the serum levels for IgA, IgG and IgM.…”

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis

“…Over the last two decades, the interrelationship between RA and periodontitis (PD) has become increasingly appreciated (5). Several studies have shown an increased frequency of periodontitis (PD) in patients with RA compared to individuals without RA (6-9). It also has been found that measures of RA disease severity (e.g.…”