Serum Antibodies to Gangliosides in Systemic Lupus Erythematosus^a

Anti-ganglioside antibodies in patients with systemic lupus erythematosus and neurological manifestations

“…Antiganglioside (anti-asialo-GM1) antibodies were first associated with neuropsychiatric lupus by Hirano et al 13 and the finding was supported by Endo et al 14 and others. [15][16][17][18][19] Furthermore, in a cohort of 91 patient with connective tissue disease, 38 of them with neuropsychiatric manifestations (including 22 SLE patients with neurological manifestations), Weiner et al 20 found a 63% prevalence of anti-ganglioside antibodies. However, no correlation was found between these antibodies and major neuropsychiatric manifestations.…”

“…12 A number of studies have explored the presence of AGA in SLE patients, focusing on neuropsychiatric manifestations and peripheral neuropathy with contradictory results. [13][14][15][16][17][18][19][20] It must be pointed out that the origin, the number of the antigens studied and the methods used were different in each study. Until now, all studies of anti-ganglioside antibodies in SLE patients have been performed using non-standardized ELISA methods, and they did not perform TLC as a confirmatory test of ELISA results.…”