Serum Antibody Levels in Smoker and Non‐Smoker Saudi Subjects With Chronic Periodontitis

Abstract

Current observations indicate that cigarette smoking may be associated with the suppression of B-cell function and immunoglobulin production. The alteration of antibody levels further explains the potential mechanism by which smoking exacerbates periodontal disease. Further studies at the molecular level may highlight the specific mechanism by which tobacco can interact with cells of the immune system and its impact on periodontal disease process.

Immunoglobulin G (IgG) Class, but Not IgA or IgM, Antibodies to Peptides of thePorphyromonas gingivalisChaperone HtpG Predict Health in Subjects with Periodontitis by a Fluorescence Enzyme-Linked Immunosorbent Assay

“…3), as has been reported by others (1,14,28). We were, however, concerned that variation in the total IgG might influence the results of our antipeptide assays, so we examined the data for any evidence of correlations between those values for each subject.…”

Impact of smoking on inflammation: overview of molecular mechanisms

“…Graswinckel et al [52] showed that non-smoker periodontitis patients had higher plasma levels of total IgG and IgG2 than smokers with periodontitis. In a recent investigation, Al-Ghamdi and Anil [53] assessed the alterations of serum immunoglobulin levels in smokers with periodontitis. Data analysis demonstrated that IgG and IgA serum levels were significantly lower in smokers compared to non-smokers and healthy controls; and that IgM serum levels tended to be lower in smokers.…”

Increased Levels of Serum and Gingival Crevicular Fluid Monocyte Chemoattractant Protein‐1 in Smokers With Periodontitis

“…It is well documented that smoking can impair various components of the host response and immune system 6‐12 . These effects include inhibition of neutrophil chemotaxis and phagocytosis, 6 inhibition of cellular immunity, and suppression of local antibody production.…”