Serum antimüllerian hormone in response to dietary management and/or physical exercise in overweight/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial

Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

“…Ultimately, 19 articles from 17 different studies were included for review. Two of the articles constituted secondary analyses (Moran et al , 2007a; Nybacka et al , 2013) of data collected during a previous dietary intervention (Moran et al , 2006; Nybacka et al , 2011). …”

“…To that end, there is utility in identifying the endocrine or metabolic characteristics that distinguish responders from non-responders prior to dietary intervention. Nine of the studies evaluated baseline clinical predictors of improvements in reproductive function (Moran et al , 2003, 2007a; van Dam et al , 2004; Thomson et al , 2008, 2009; Kuchenbecker et al , 2011; Nybacka et al , 2011, 2013; Pasquali et al , 2011). …”

“…None of the studies assessed predictors of the transition to normal ovulatory function. Improvements in menstrual cyclicity were broadly characterized as a decrease in menstrual cycle irregularity, shift from irregular to regular menstrual cycles or shift from anovulatory to ovulatory cycles (Moran et al , 2003, 2007a, Thomson et al , 2008, 2009, Nybacka et al , 2011, 2013). Increased cycle regularity was not necessarily accompanied by improvements in ovulation and a shift from anovulatory to ovulatory cycles appeared to reflect evidence of sporadic, rather than regular, ovulation (Moran et al , 2003, 2007a; Thomson et al , 2009).…”

“…As shown in Table 3, six of the nine studies identified significant clinical predictors of improved reproductive outcomes following dietary intervention (van Dam et al , 2004; Moran et al , 2007a; Thomson et al , 2009; Nybacka et al , 2011, 2013; Pasquali et al , 2011). The baseline characteristics that emerged were largely markers of androgen excess and adiposity.…”

“…The baseline characteristics that emerged were largely markers of androgen excess and adiposity. Overall, women with lower circulating concentrations of sex hormone binding globulin (van Dam et al , 2004), testosterone (Nybacka et al , 2011), androstenedione (Pasquali et al , 2011) and anti-Müllerian hormone (AMH) (Moran et al , 2007a; Thomson et al , 2009; Nybacka et al , 2013) were more likely to experience sporadic ovulation and improved menstrual cyclicity during dietary intervention. A lower waist circumference and waist-to-hips ratio were also predictive of recovery from the syndrome (Pasquali et al , 2011).…”