1993
DOI: 10.1136/gut.34.1.46
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Serum antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis. A correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical, and surgical treatment.

Abstract: Perinuclear antineutrophil cytoplasmic antibodies have recently been demonstrated in

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Cited by 114 publications
(34 citation statements)
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“…However, in contrast to systemic vasculitides in which the presence and titers of pANCA are related to disease activity and can be used as diagnostic and prognostic tools [7], there are conflicting results on the relationship between pANCA and disease activity or the clinical course of UC. Although pANCA-positive patients were shown to have a more refractory type of disease than pANCA-negative patients in a few anecdotal investigations [8,9], most studies have failed to detect clinical differences in UC between pANCA-positive and -negative patients [4,10]. However, these investigations were exclusively performed in Western countries, and it is not clear whether the results can be equally applied to Asian UC patients who have very different environmental and genetic backgrounds.…”
Section: Introductionmentioning
confidence: 99%
“…However, in contrast to systemic vasculitides in which the presence and titers of pANCA are related to disease activity and can be used as diagnostic and prognostic tools [7], there are conflicting results on the relationship between pANCA and disease activity or the clinical course of UC. Although pANCA-positive patients were shown to have a more refractory type of disease than pANCA-negative patients in a few anecdotal investigations [8,9], most studies have failed to detect clinical differences in UC between pANCA-positive and -negative patients [4,10]. However, these investigations were exclusively performed in Western countries, and it is not clear whether the results can be equally applied to Asian UC patients who have very different environmental and genetic backgrounds.…”
Section: Introductionmentioning
confidence: 99%
“…Perinuclear antineutrophil cytoplasmic antibodies (pANCA) are found in 60 to 80 percent of UC patients. [18][19][20] pANCA also are present in 15 to 25 percent of patients with CD, in whom it is associated with a "UC-like" clinical picture. 21 Anti-Saccharomyces cervesiae antibodies (ASCA) are found in approximately 60 percent of CD patients.…”
mentioning
confidence: 99%
“…En 1990, Saxon et al 3 encontraron la presencia de anticuerpos anticitoplasma de los neutrófilos (ANCA) en pacientes con EII. Desde entonces, estudios posteriores han confirmado dicha asociación [3][4][5][6][7][8][9][10][11][12][13] . Según su patrón de inmunofluorescencia indirecta sobre leucocitos polimorfonucleares (PMN) humanos fijados con etanol se ha descrito: el patrón citoplasmático granular difuso cANCA, causado por anticuerpos antiproteinasa 3 (PR3), el patrón de tinción citoplasmático perinuclear pANCA, causado por anticuerpos dirigidos en contra de diferentes antígenos, entre ellos: mieloperoxidasa, elastasa, cathepsina G, azurocidina, lactoferrina, lisosima, etc.…”
Section: N V E S T I G a C I ó Nunclassified
“…Según su patrón de inmunofluorescencia indirecta sobre leucocitos polimorfonucleares (PMN) humanos fijados con etanol se ha descrito: el patrón citoplasmático granular difuso cANCA, causado por anticuerpos antiproteinasa 3 (PR3), el patrón de tinción citoplasmático perinuclear pANCA, causado por anticuerpos dirigidos en contra de diferentes antígenos, entre ellos: mieloperoxidasa, elastasa, cathepsina G, azurocidina, lactoferrina, lisosima, etc. y un tercer grupo «atípico», del cual no se conoce la especificidad antigénica y que presenta un patrón de tinción citoplasmática difusa junto con tinción perinuclear, sin embargo, en la literatura el ANCA asociado con EII ha recibido históricamente el nombre de «p-ANCA» [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] .…”
Section: N V E S T I G a C I ó Nunclassified