Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies

Krzemień, Paweł; Kasperczyk, Sławomir; Banach, Maciej; Kasperczyk, Aleksandra; Dobrakowski, Michał; Tomasik, Tomasz; Windak, Adam; Mastej, Mirosław; Catapano, Alberico L.; Ray, Kausik K.; Mikhailidis, Dimitri P.; Tóth, Peter P.; Howard, George; Lip, Gregory Y.H.; Tomaszewski, Maciej; Charchar, Fadi J.; Sattar, Naveed; Williams, Bryan; MacDonald, Thomas M.; Penson, Peter E.; Jóźwiak, Jacek Jerzy

doi:10.5114/aoms/139313

Cited by 4 publications

(1 citation statement)

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“…However, negative associations between smoking and autoantibody prevalence have been described as well, e.g., for SLE autoantibodies ( 42 , 43 ) and for thyroid autoantibodies ( 44 ). Also, similarly to our findings, ANA prevalence has been shown to be inversely associated with the frequency of smoking ( 45 , 46 ), while other studies did not observe any association between smoking and ANA prevalence ( 47 ). Overall, data regarding the interaction of smoking and autoantibody prevalence appear to be conflicting.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of a large panel of systemic autoantibodies in the Bavarian adult population

Rohm,

Kling,

Hoffmann

et al. 2024

Front. Immunol.

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ObjectiveAutoimmune diseases commonly feature the presence of specific humoral autoantibodies. However, the prevalence of a large panel of systemic autoantibodies has never been assessed in the general population. We, therefore, described the prevalence of about 50 humoral systemic autoantibodies in a sample of the general Bavarian adult population.MethodsNon-fasting venous serum samples from 331 participants were analyzed for 7 autoantibody screening tests (nuclear, cytoplasmic, and mitotic ANA, ANCA, cANCA and pANCA, anti-ENA autoantibodies) and 44 different monospecific humoral non-organ specific/systemic autoantibodies using indirect immunofluorescence tests, ELISAs, and line blots. In order to assess associations between sex, age, BMI, education level, smoking status and the presence of systemic autoantibodies, logistic regression analyses were conducted.ResultsAt least one screening test was positive in 29.9% of the participants, and 42.3% of the participants were seropositive for at least one monospecific autoantibody. The most frequently found monospecific autoantibodies were rheumatoid factor (35.6%), ß2-glycoprotein 1 IgM (4.8%), and cardiolipin IgG (1.8%). Only few associations between sex, age, BMI, education, smoking status and autoantibody frequencies were observed.ConclusionSystemic autoantibodies are common in the general Bavarian population, and largely independent of sex, age, BMI, education, or smoking status. The study results may give orientation to clinicians about the occurrence of autoantibodies in the population, not (yet) associated with clinical symptoms.

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