Serum antioxidant and cholesterol levels in patients with different types of cancer

Abiaka, Clifford; Al-Awadi, Farida; Al‐Sayer, H.; Gulshan, S.; Behbehani, A.; Farghally, Medhat; Simbeye, Amos

doi:10.1002/jcla.1045

Cited by 21 publications

(12 citation statements)

References 35 publications

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“…Moreover, in other types of cancer, e.g. in stomach, colon, rectal and breast cancers, depletion of serum alpha tocopherol was also observed [52]. In this study, the observed decreased of serum VE did not result from vitamin E intakes which were comparable between lung cancer and control women, while in the group of lung cancer men, dietary intakes of this vitamin were even higher in comparison to control men.…”

Section: Discussionsupporting

confidence: 52%

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

et al. 2019

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In lung cancer (LC), alterations in redox balance are extensively observed and are a consequence of disease as well as co-occurrent with smoking. We previously demonstrated that metabolic disturbances such as trace element status and carbohydrate metabolism alterations are linked with redox status. The aim of this study was to evaluate relationships between the serum parameters of lipid metabolism and redox balance in LC patients. Serum parameters of lipid metabolism, i.e. total cholesterol (T-C), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TG), T-C:HDL-C ratio, non-HDL-C, apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B) and Apo-B:Apo-A1 ratio, as well as systemic redox status, i.e. total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), vitamin E (VE), vitamin C (VC), malonyldialdehyde (MDA), conjugated dienes (CD), and 4-hydroxynonenal (4-HNE) were determined in 92 LC patients and 82 control subjects (CS). LC women had significantly lower T-C and LDL-C, and higher TG, while HDL-C, Apo-A1 and Apo-B were significantly decreased in LC patients regardless of sex, when compared to CS. LC men had alterations in the systemic total redox balance such as lower TAS and higher OSI than CS men. LC women had lower VC, but VE was decreased in LC patients, regardless of sex. We observed higher lipid peroxidation in LC patients expressed via higher 4-HNE and CD. Systemic redox disturbances were associated with serum lipid alterations: TOS and OSI were positively correlated with T-C:HDL-C ratio and Apo-B:Apo-A1 ratio and negatively with HDL-C. The parameters of lipid peroxidation CD and MDA were significantly associated with variables reflecting lipid disturbances. The observed correlations were strengthened by general overweight/obesity, abdominal obesity, hypertriglyceridemia and non-smoking status. In conclusion, parameters related to lipid alterations are associated with oxidative stress in LC patients. The largest contribution from lipid parameters was revealed for T-C:HDL-C ratio, HDL-C and Apo-B:Apo-A1 ratio, while the largest contribution from redox status was revealed for OSI and VE. Overweight, obesity, hypertriglyceridemia and non-smoking status intensified these relationships.

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Section: Discussionsupporting

confidence: 52%

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

et al. 2019

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“…Evaluation of the effect of AT on pancreatic carcinogenesis in rodent models has reported beneficial (11)(12)(13) and null (14,15) results. Epidemiologic studies that have examined dietary vitamin E (16,17), serum AT (18)(19)(20)(21), or AT supplement interventions (22)(23)(24)(25) and pancreatic cancer risk show inconsistent results. Most, including randomized trials that have examined pancreatic cancer as a secondary outcome (22)(23)(24)(25), have limited power to detect associations (18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 93%

Vitamin E intake, α-tocopherol status, and pancreatic cancer in a cohort of male smokers

Sheffler‐Collins

Weinstein

Garabrant

et al. 2009

The American Journal of Clinical Nutrition

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“…These free radicals are unstable because they are missing electrons, which must be replaced. If the compound giving up its electrons is the fat and protein in an LDL-cholesterol molecule, the result is the formation of fatty lesions in the walls of the blood vessels (Abiaka et al, 2001).…”

Section: Cholesterol Lowering Effectmentioning

confidence: 99%

Effects of Aqueous Leaf Extract of Cashew Anacardium Occidentale on Paracetamol Induced Hepatotoxicity of Adult Male Wistar Rats

Okonkwo¹,

V.N.²,

Edeh³

2018

IJTSRD

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While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion. Adverse events typically associated with paracetamol intoxication include acute liver failure (ALF), centrilobular hepatic necrosis, renal tubular necrosis and hypoglycemic coma. Cashew (Anacardium occidentale) has been used both as source of nutrition and medicinally worldwide. A total of 25 adult male Wistar rats weighing 100g-200g were used for this study. The animals were divided into 5 groups of 5 rats each. 1000mg/kg/body weight of paracetamol was given for 3 days to induce liver damage in groups BE. Group A served as the normal control group and received feed and water throughout the period of the experiment. Group B served as negative control group and received feeds and water throughout the period of the experiment, but no treatment with the extract. Group C, D and E received 150mg, 300mg and 500mg/kg of the extract for 21 days. All data obtained were subjected to statistical analysis using t-test, one-way ANOVA and POST HOC LSD using SPSS version 20. Differences between means were regarded significant at P<0.05. Data were expressed as mean + standard error of mean (SEM). The result showed a significant increase in AST in Group E (P<0.05) when compared to Group A. However, there was a decrease in Group C when compared to Group B. Also, there was a significant increase in ALT in Group D (P<0.05) and Group E (P<0.05), when compared to Group A. However, there was a decrease in Group C for both AST and ALT when compared to Group B. From this study, it can be said that aqueous leaf extract of Anacardium occidentale has a little correction effect on Paracetamol induced hepatotoxicity in small doses. However, it can exert a serious toxic effect on the liver with increased dosage. 1.1 BACKGROUND OF STUDY Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 has been available over-the-counter as a

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Serum antioxidant and cholesterol levels in patients with different types of cancer

Cited by 21 publications

References 35 publications

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

Vitamin E intake, α-tocopherol status, and pancreatic cancer in a cohort of male smokers

Effects of Aqueous Leaf Extract of Cashew Anacardium Occidentale on Paracetamol Induced Hepatotoxicity of Adult Male Wistar Rats

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