Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome

Milanlıoğlu, Aysel; Aslan, Mehmet; Özkol, Halil; Çilingir, Vedat; Aydın, Mehmet Nuri; Karadaş, Sevdegül

doi:10.1007/s00508-015-0742-6

Cited by 52 publications

(30 citation statements)

References 39 publications

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“…The increase in SOD activity after 1 week corresponds with the results of the present study for HS patients (32). Milanlioglu et al (29) found similar results to that of the present study; no significant differences in serum GPx was found between stroke patients and healthy controls. Demirkaya et al (2001) found that red blood cell GPx activity decreased in the first 24 hours after the onset of stroke symptoms as compared with the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Hydrogen peroxide is, in turn, trapped by CAT and GPx and converted to H 2 O and O 2 molecules. The balance between oxidative and antioxidant mechanisms of these enzymes is a critical component in cells against nerve damage associated with oxidative stress (29). Antioxidant enzymes in the plasma and red blood cells are the most important factors preventing oxidative damage caused by neurological diseases such as stroke (17).…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, Sheikh et al (19) reported similar findings. According to some previous reports, the different measurement methods and isoenzymes are the underlying reason for the contradictory behavior; however, further research is needed to investigate these behaviors (29,32).…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

et al. 2016

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Background and Aim: Oxidative stress is a major mechanism involved in stroke pathogenesis. The present study evaluated and compared oxidative stress parameters in patients with ischemic and hemorrhagic stroke (IS and HS) at the time of hospitalization and 1 week after hospitalization. Methods: This was a case-control study with 87 stroke patients (58 IS and 29 HS) as the case and 58 normal individuals as the control group. Sampling was done at the time of hospitalization and after 1 week. The serum total antioxidant capacity (TAC), thiol group, and F2-isoprostan levels were measured using Ferric Reducing Antioxidant Power (FRAP), Elman, and Enzyme Linked Immunosorbent Assay ELISA methods, respectively. Results: At the time of hospitalization, there was no significant difference in TAC and F2-isoprostan levels between the case and

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

et al. 2016

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“…In the last years, the relation between CoQ 10 and inflammation and oxidative stress has been reported in cell and animal models. Glial fibrillary acidic protein (GFAP), MDA, and superoxide dismutase (SOD) activity are important biomarkers in oxidative stress and neuroinflammatory processes after stroke, and they can predict functional outcomes [134][135][136]. In a short RCT, 60 patients with acute ischemic stroke were randomly assigned to a placebo or CoQ 10 -supplemented group (300 mg/day) for 4 weeks.…”

Section: Coq 10 and Ischemic Strokementioning

confidence: 99%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ10 is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ10 supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ10 supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

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“…Increased oxidative stress and decreased antioxidant enzymes activity may play a role in the pathogenesis of both ischemic stroke and hemorrhagic stroke (30,31). The management of oxidative stress also showed promising results with significant improvement of long-term neurological function (32).…”

Section: Shared Pathophysiological Mechanismsmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Stroke

Corlăteanu

Covanţev

Mathioudakis

et al. 2018

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world and its incidence and prevalence is on the rise. It is evident that COPD is linked to cardiovascular disease. In the last years, several studies demonstrated that COPD may also be a risk factor for stroke, another major cause of death worldwide. Taking in consideration that COPD has multiple comorbidities it is hard to say whether COPD is an independent risk factor for stroke or it is due to confounding effect. This review is aimed to discuss current data on COPD and stroke, potential links, therapy, and prevention. Current data suggest that COPD may increase the risk of hemorrhagic stroke. The incidence of other stroke subtypes may also be increased in COPD or may be due to confounding effect. However, COPD patients who have stroke are at risk for pulmonary and extrapulmonary complications. We conclude that more studies are needed to further clarify the links between COPD and stroke. The management of COPD as well as the use of prevention therapy is essential to decrease the risk for stroke and should be at special attention in pulmonary medicine and neurology.

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Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome

Abstract: Our study demonstrated that acute ischemic stroke patients have increased oxidative stress and decreased antioxidant enzymes activities. These findings indicated that an imbalance of oxidant and antioxidant status might play a role in the pathogenesis of acute ischemic stroke.

Cited by 52 publications

References 39 publications

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

Chronic Obstructive Pulmonary Disease and Stroke

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