Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Hossain, Kazi Jahangir; Kamal, Mustafa; Ahsan, Monira; Islam, Md. Saidul

doi:10.1186/1747-597x-2-12

Cited by 29 publications

(31 citation statements)

References 37 publications

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“…No significant differences in the serum zinc level of drug abuser patients was found before and after clinical intervention and when compared to control (p>0.05). Previous studies [12,15,16,29] reported a higher serum copper level in drug abusers than the control group, which is similar to our study finding. After intervention, the serum level of copper decreased significantly (p<0.05) in our study, which is similar to a previous study [12].…”

Section: Discussionsupporting

confidence: 95%

“…The decreased iron level may be associated with malnutrition [30] and vitamin A deficiency [31], which is also prevalent in drug abuser or dependent patients [15,32,33]. But after intervention, iron level was restored to normal value.…”

Section: Discussionmentioning

confidence: 97%

“…It is also reported that overload of trace elements produces immunotoxicity [8,9]. Changes in trace element level due to drug abuse have been reported by some investigators [12][13][14][15][16]. These studies have tested the hypothesis that illicit drug use and lifestyle impair serum trace element status.…”

Section: Introductionmentioning

confidence: 94%

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Investigation of Serum Trace Element, Malondialdehyde and Immune Status in Drug Abuser Patients Undergoing Detoxification

Mannan

Azad

Ullah

et al. 2010

Biol Trace Elem Res

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Drug abuser patients (n=104), age ranging from 19 to 42 years, were randomly recruited to investigate the serum levels of trace elements (Cu, Zn, Fe, and Mg), malondialdehyde (MDA), and immunoglobulin (IgG, IgA, and IgM) before and after clinical intervention. Control group also included 104 healthy individuals. Blood samples were analyzed for determining trace elements, MDA, and immunoglobulin using atomic absorption spectroscopy, Ultraviolet-Visible (UV-VIS) spectroscopy, and turbidimetry method, respectively. For serum level of Zn and Fe, the differences between the groups (before intervention, after intervention, and control) were not significant (p>0.05). However, significant differences were found in serum copper levels between control group, drug abuser patients, and before and after intervention (p<0.05). The concentration of Mg was found to be significantly higher (p=0.007) in drug abuser patients than the controls, and after intervention, the level was restored to control value. A displacement of elemental homeostasis was observed in drug abuser patients compared to control, and it was improved after intervention. An increase in serum concentration of MDA was found in drug abuser patients compared to control subjects (p>0.05) but was not statistically significant. After intervention, the concentration was restored to control value (p>0.05). The serum concentrations of IgA and IgM were found to be significantly higher (p<0.05) in drug abuser patients before intervention than the controls, and the level tended to be restored to control level after clinical intervention. Serum IgG level was found to be lower in drug abuser patients compared to controls and further declined significantly (p<0.05) after intervention. These findings may suggest a possible imbalance in the levels of micronutrients, antioxidants, and immunoglobulin in drug abuser patients, which tend to be restored to control values after detoxification.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 97%

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Investigation of Serum Trace Element, Malondialdehyde and Immune Status in Drug Abuser Patients Undergoing Detoxification

Mannan

Azad

Ullah

et al. 2010

Biol Trace Elem Res

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“…[24] Copper (Cu) is a trace element that regulates the functions of several cuproenzymes that are essential for life [24] and plays a significant role in antioxidant defense and immune development. [28] Zn and Cu are beneficial during pregnancy. Both excesses and deficiencies have been reported to have profound and sometimes persistent effects on many fetal tissues and organs in the absence of clinical signs of deficiency in the mother.…”

Section: Introductionmentioning

confidence: 99%

Parity-related changes in body weight may influence the zinc and copper status of urban pregnant women: A report from south eastern Nigeria

Nwagha

Iyare

Ogbodo³

et al. 2013

J Basic Clin Reprod Sci

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A B S T R A C TBackground: Micronutrient replacement is done indiscriminately, without recourse to peculiar socioeconomic and sociodemographic variables. Particularly, the relationship between parity, body weight, and some micronutrients has received minimal attention in Nigeria. Aim: To determine the relationship between parity, body weight, and some micronutrients during pregnancy. Subjects and Methods: This is a cross-sectional study involving 130 pregnant women and 30 nonpregnant control. They were recruited from two health care facilities in Nigeria and grouped into nulliparous and multiparous. After a 24-h dietary recall, the weight (W) and height (H) were measured. The body mass index (BMI) (W in kg/H in m 2 ) was calculated. Serum copper and zinc were estimated using flame atomic absorption spectrophotometer. Results: Multiparous nonpregnant subjects parity=3.0 (0.58) had higher weight (P=0.037) and BMI (P=0.035) than their nulliparous counterparts (parity=0). In addition, there were no significant difference in Cu and zinc levels between the two groups (P=0.243 and 0.402, respectively). Expectedly, weight and BMI increased as pregnancy progressed. There was no significant difference in Cu levels between the three trimesters in the nulliparous pregnant and multiparous pregnant subjects. In the pregnant nulliparous subjects, the Zn levels of the 2 nd and 3 rd trimesters were significantly lower than that of the nonpregnant nulliparous subjects (P<0.001 and 0.039, respectively). However, in multiparous pregnant subjects, only the 3 rd trimester Zn level was significantly lower than that of the nonpregnant controls (P=0.017). Conclusion: Pregnancy weight gain is more pronounced in multiparous than nulliparous women. This parity-related pattern only affects the serum zinc levels, a situation that should be taken into consideration when formulating policies for nutritional replacement.

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“…The negative correlation between newborn head circumference and maternal plasma copper level suggests a relationship between newborn anthropometrics and maternal plasma mineral levels. Copper and zinc are essential elements, which play essential roles in several enzymes and transcription factors that regulate growth and development 40,41 . Both excesses and deficiencies of copper and zinc have been reported to have profound and sometimes, persistent effects on many foetal tissues and organs in the absence of clinical signs of deficiency in the mothers 8 .…”

Section: Singh Et Almentioning

confidence: 99%

The effect of parity on maternal body mass index, plasma mineral element status and new-born anthropometrics

Ugwuja¹,

Nnabu²,

Ezeonu³

et al. 2015

Afr H. Sci.

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Background: Adverse pregnancy outcome is an important public health problem that has been partly associated with increasing maternal parity. Aim: To determine the effect of parity on maternal body mass index (BMI), mineral element status and newborn anthropometrics. Methods: Data for 349 pregnant women previously studied for the impacts of maternal plasma mineral element status on pregnancy and its outcomes was analysed. Obstetric and demographic data and 5mls of blood samples were obtained from each subject. Blood lead, plasma copper, iron and zinc were determined using atomic absorption spectrophotometer. Results: Maternal BMI increases with parity. Women with parity two had significantly higher plasma zinc but lower plasma copper with comparable levels of the elements in nulliparous and higher parity groups. Although plasma iron was comparable among the groups, blood lead was significantly higher in parity > three. Newborn birth length increases with parity with a positive correlation between parity and maternal BMI (r = 0.221; p = 0.001) and newborn birth length (r = 0.170; p = 0.002) while plasma copper was negatively correlated with newborn's head circumference (r = -0.115; p = 0.040) Conclusion: It is plausible that parity affects maternal BMI and newborn anthropometrics through alterations in maternal plasma mineral element levels. While further studies are desired to confirm the present findings, there is need for pregnant and would-be pregnant women to diversify their diet to optimize their mineral element status.

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Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Cited by 29 publications

References 37 publications

Investigation of Serum Trace Element, Malondialdehyde and Immune Status in Drug Abuser Patients Undergoing Detoxification

Investigation of Serum Trace Element, Malondialdehyde and Immune Status in Drug Abuser Patients Undergoing Detoxification

Parity-related changes in body weight may influence the zinc and copper status of urban pregnant women: A report from south eastern Nigeria

The effect of parity on maternal body mass index, plasma mineral element status and new-born anthropometrics

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