Serum Apelin-36 alteration in late pregnancy and early lactation of dairy cows and its association with negative energy balance markers

Norvezh, Farideh; Jalali, Mohammad Hossein Razi; Tabandeh, Mohammad Reza; Hajikolaei, Mohammad Rahim Haji; Gooraninejad, Saad

doi:10.1016/j.rvsc.2019.07.012

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…Apelin and its G protein-coupled receptor (APJ, apelin-angiotensin receptor-like 1) regulate glucose homeostasis in humans by increasing both glucose uptake and insulin sensitivity [34]. The increase of apelin levels in type 2 diabetes mellitus (T2DM) or obesity indicates an association between apelinemia and impaired glucose regulation [35]. Apelin stimulates various signaling pathways that decrease both cAMP and cAMPinduced AMPK activation.…”

Section: Discussionmentioning

confidence: 99%

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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Background: The available data on the significance of circulating apelin, chemerin and omentin in women with gestational diabetes mellitus (GDM) are inconsistent. This analysis includes a systematic review of the evidence associating the serum concentrations of these adipokines with GDM. Methods: Publications through December 2019 were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science. Subgroup analysis and meta-regression were conducted to evaluate sources of heterogeneity. Results: Analysis of 20 studies, including 1493 GDM patients and 1488 normal pregnant women did not find significant differences in circulating apelin and chemerin levels (apelin standardized mean difference [SMD] = 0.43, 95% confidence interval (CI): − 0.40 to 1.26, P = 0.31; chemerin SMD = 0.77, 95% CI − 0.07 to 1.61, P = 0.07). Circulating omentin was significantly lower in women with GDM than in healthy controls (SMD = − 0.72, 95% CI − 1.26 to − 0.19, P = 0.007). Publication bias was not found; sensitivity analysis confirmed the robustness of the pooled results. Conclusions: Circulating omentin was decreased in GDM patients, but apelin and chemerin levels were not changed. The results suggest that omentin has potential as a novel biomarker for the prediction and early diagnosis of GDM.

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Section: Discussionmentioning

confidence: 99%

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

et al. 2020

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“…Norvezh et al . [ 116 ] demonstrated that alteration in the secretion of apelin-36 in dairy cow during early lactation may represent an endocrine adaptation mechanism during this critical period of lactation. Bhat et al .…”

Section: Apelinmentioning

confidence: 99%

“…Nutritional status can affect apelin in serum and a hypercaloric diet increases adipose tissue and plasma apelin concentrations [114,115]. Norvezh et al [116] demonstrated that alteration in the secretion of apelin-36 in dairy cow during early lactation may represent an endocrine adaptation mechanism during this critical period of lactation. Bhat et al [117] used milk proteome analysis technique to explore the bioactive components of bovine milk and identified apelin as a major regulator of immune system in Kashmiri cattle.…”

Section: Apelinmentioning

confidence: 99%

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Alhussien

Dang

2020

Vet World

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Dairy cows are exposed to various stressors during their production cycle that makes them more susceptible to various diseases. Phagocytes (neutrophils and macrophages) are important soldiers of the innate immune system. Neutrophils are the first responders to an inflammatory response and stress and kill pathogens by generating reactive oxygen species and by the release of various antimicrobial peptides, enzymes, neutrophil extracellular trap formation, etc. Macrophages, the other phagocytes, are also the cleanup crew for the innate immune system that removes debris, pathogens, and dead neutrophils later on after an inflammatory response. The neuroendocrine system along with phagocytes exhibits an immunomodulatory potential during stressful conditions. Neuroendocrine system directly affects the activity of phagocytes by communicating bidirectionally through shared receptors and messenger molecules such as hormones, neurotransmitters, or cytokines. Different immune cells may show variable responses to each hormone. Short time exposure to stress can be beneficial, but repeated or extended exposure to stress may be detrimental to the overall health and well-being of an animal. Although some stresses associated with farming practices in dairy cows are unavoidable, better understanding of the interactions occurring between various stress hormones and phagocytic cells can help to reduce stress, improve productivity and animal welfare. This review highlights the role played by various stress hormones in modulating phagocytic cell performance of dairy cattle under inflammatory conditions.

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“…Using an ELISA that exclusively detects apelin-36, decreased apelin-36 concentrations accompanied with decreased insulin and glucose concentrations were observed in primiparous and multiparous cows during the transition period with concomitant BCS reduction (Norvezh et al, 2019). Regarding the contradicting results to Weber et al (2016a), Norvezh et al (2019) suggested that the proportion of the different apelin peptides might change during the periparturient period, without affecting the overall serum apelin concentrations. Moreover, markers related to NEB in dairy cows, such as FFA, insulin, and glucose concentrations, were associated with decreasing apelin-36 serum concentrations around calving.…”

Section: Hmw Mainly In Cows Table 1 (Continued)mentioning

confidence: 99%

“…Moreover, markers related to NEB in dairy cows, such as FFA, insulin, and glucose concentrations, were associated with decreasing apelin-36 serum concentrations around calving. Thus, the altered apelin-36 concentrations during the periparturient period might be involved in adaptations of dairy cows to NEB in early lactation (Norvezh et al, 2019).…”

Section: Hmw Mainly In Cows Table 1 (Continued)mentioning

confidence: 99%

Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows

Häußler

Sadri

Ghaffari

et al. 2022

Journal of Dairy Science

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The involvement of adipose tissue (AT) in metabolism is not limited to energy storage but turned out to be much more complex. We now know that in addition to lipid metabolism, AT is important in glucose homeostasis and AA metabolism and also has a role in inflammatory processes. With the discovery of leptin in 1994, the concept of AT being able to secrete messenger molecules collectively termed as adipokines, and acting in an endo-, para-, and autocrine manner emerged. Moreover, based on its asset of receptors, many stimuli from other tissues reaching AT via the bloodstream can also elicit distinct responses and thus integrate AT as a control element in the regulatory circuits of the whole body's functions. The protein secretome of human differentiated adipocytes was described to comprise more than 400 different proteins. However, in dairy cows, the characterization of the physiological time course of adipokines in AT during the transition from pregnancy to lactation is largely limited to the mRNA level; for the protein level, the analytical methods are limited and available assays often lack sound validation. In addition to proteinaceous adipokines, small compounds such as steroids can also be secreted from AT. Due to the lipophilic nature of steroids, they are stored in AT, but during the past years, AT became also known as being able to metabolize and even to generate steroid hormones de novo. In high-yielding dairy cows, AT is substantially mobilized due to increased energy requirements related to lactation. As to whether the steroidogenic system in AT is affected and may change during the common loss of body fat is largely unknown. Moreover, most research about AT in transition dairy cows is based on subcutaneous AT, whereas other depots have scarcely been investigated. This contribution aims to review the changes in adipokine mRNA andwhere available-protein expression with time relative to calving in high-yielding dairy cows at different conditions, including parity, body condition, diet, specific feed supplements, and health disorders. In addition, the review provides insights into steroidogenic pathways in dairy cows AT, and addresses differences between fat depots where possible.

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Serum Apelin-36 alteration in late pregnancy and early lactation of dairy cows and its association with negative energy balance markers

Cited by 6 publications

References 38 publications

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: a systematic review and meta-analysis

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows

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