Serum Apolipoprotein B-48 Concentration Is Associated with a Reduced Estimated Glomerular Filtration Rate and Increased Proteinuria

Okubo, Masao; Hanada, Hiroyuki; Matsui, M; Hidaka, Yoh; Masuda, Daisuke; Sakata, Yasushi; Yamashita, Shizuya

doi:10.5551/jat.23309

Cited by 11 publications

(7 citation statements)

References 30 publications

(25 reference statements)

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“…High apoB-48 levels are also observed in subjects with clinical and subclinical hypothyroidism, and it was suggested that hypothyroidism might correlate with the accumulation of remnant lipoproteins 76 ) . Proteinuria and a reduced estimated glomerular filtration rate (eGFR) are independent risk factors for renal dysfunction and ASCVD events in CKD patients, and we found that log-apoB-48 and logapoB-48/TG levels are significantly higher in subjects with both low eGFR (<60 mL/min/1.73 m 2 ) and proteinuria (≥1+ by urine dipstick) than those with high eGFR and without proteinuria, which imply that an increased accumulation of CM remnants contributes to an increased risk of ASCVD events in CKD patients 77 ) . Similar to CKD patients, Hayashi et al also showed that apoB-48 levels gradually increased as renal dysfunction worsened to end-stage renal disease (ESRD) in patients with diabetic nephropathy who were receiving hemodialysis 78 ) .…”

Section: Apolipoprotein B-48 Concentration and Metabolic Disordersmentioning

confidence: 51%

Postprandial Hyperlipidemia and Remnant Lipoproteins

Masuda

Yamashita

2017

J Atheroscler Thromb

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127

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Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation. The cholesterol levels of remnant lipoproteins significantly correlate with small, dense LDL; impaired glucose tolerance (IGT) and CHD prevalence. We have developed an assay of apolipoprotein (apo)B-48 levels to evaluate the accumulation of CM remnants. Fasting apoB-48 levels correlate with the morbidity of postprandial hypertriglyceridemia, obesity, type III hyperlipoproteinemia, the metabolic syndrome, hypothyroidism, chronic kidney disease, and IGT. Fasting apoB-48 levels also correlate with carotid intima-media thickening and CHD prevalence, and a high apoB-48 level is a significant predictor of CHD risk, independent of the fasting TG level. Diet interventions, such as dietary fibers, polyphenols, medium-chain fatty acids, diacylglycerol, and long-chain n-3 polyunsaturated fatty acids (PUFA), ameliorate postprandial hypertriglyceridemia, moreover, drugs for dyslipidemia (n-3 PUFA, statins, fibrates or ezetimibe) and diabetes concerning incretins (dipeptidyl-peptidase IV inhibitor or glucagon like peptide-1 analogue) may improve postprandial hypertriglyceridemia. Since the accumulation of CM remnants correlates to impaired lipid and glucose metabolism and atherosclerotic cardiovascular events, further studies are required to investigate the characteristics, physiological activities, and functions of CM remnants for the development of new interventions to reduce atherogenicity.

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Section: Apolipoprotein B-48 Concentration and Metabolic Disordersmentioning

confidence: 51%

Postprandial Hyperlipidemia and Remnant Lipoproteins

Masuda

Yamashita

2017

J Atheroscler Thromb

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127

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“…Recent studies indicated that the atherogenicity of chylomicron remnants is also strong and chylomicron remnants are contained in atherosclerotic plaque as VLDL remnants [20]. And, apoB-48 levels, a marker for the accumulation of chylomicrons and chylomicron remnants, increased in accordance with the severity of CKD and the existence of proteinuria [21]. Thus, post-prandial RLP-C levels, which may contain much chylomicron remnants, might potentially have association with future cardiovascular events [22,23].…”

Section: Discussionmentioning

confidence: 99%

Remnant lipoproteinemia predicts cardiovascular events in patients with type 2 diabetes and chronic kidney disease

Nguyen

Nakamura

Uematsu

et al. 2017

Journal of Cardiology

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“…Okubo et al found that ApoB48 levels, composed of chylomicrons and their remnants, are inversely correlated with GFR levels and increased proteinuria [32]. ApoB48 levels were also found elevated in ESRD diabetic patients [33].…”

Section: Uremic Lipoproteins Evidences Of Toxicitymentioning

confidence: 99%

Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

Florens

Calzada

Lyasko

et al. 2016

Toxins

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Chronic kidney disease (CKD) is associated with an enhanced oxidative stress and deep modifications in lipid and lipoprotein metabolism. First, many oxidized lipids accumulate in CKD and were shown to exert toxic effects on cells and tissues. These lipids are known to interfere with many cell functions and to be pro-apoptotic and pro-inflammatory, especially in the cardiovascular system. Some, like F2-isoprostanes, are directly correlated with CKD progression. Their accumulation, added to their noxious effects, rendered their nomination as uremic toxins credible. Similarly, lipoproteins are deeply altered by CKD modifications, either in their metabolism or composition. These impairments lead to impaired effects of HDL on their normal effectors and may strongly participate in accelerated atherosclerosis and failure of statins in end-stage renal disease patients. This review describes the impact of oxidized lipids and other modifications in the natural history of CKD and its complications. Moreover, this review focuses on the modifications of lipoproteins and their impact on the emergence of cardiovascular diseases in CKD as well as the appropriateness of considering them as actual mediators of uremic toxicity.

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Serum Apolipoprotein B-48 Concentration Is Associated with a Reduced Estimated Glomerular Filtration Rate and Increased Proteinuria

Cited by 11 publications

References 30 publications

Postprandial Hyperlipidemia and Remnant Lipoproteins

Postprandial Hyperlipidemia and Remnant Lipoproteins

Remnant lipoproteinemia predicts cardiovascular events in patients with type 2 diabetes and chronic kidney disease

Modified Lipids and Lipoproteins in Chronic Kidney Disease: A New Class of Uremic Toxins

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