Serum Apolipoprotein Profile of Renal-Transplant Patients

Segarra, Alfons; Chacón, Pedro Méndez; Martin, Maria Rosa Melero; Piera, L

doi:10.1159/000188596

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Statin as a class are known to undergo extensive first pass extraction in the liver where they inhibit HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase activity and hence cholesterol synthesis. Therefore, they may potentially inhibit the synthesis of steroid hormones derived from cholesterol, including testosterone [103]. However, gonadal hormone levels in men with ED who take statins do not seem to be reduced [103,104].…”

Section: Lipid-lowering Drugs As a Cause Of Ed The Effects Of Statinsmentioning

confidence: 99%

“…Therefore, they may potentially inhibit the synthesis of steroid hormones derived from cholesterol, including testosterone [103]. However, gonadal hormone levels in men with ED who take statins do not seem to be reduced [103,104]. It is believed that normal adult testosterone levels are not required for normal erections to occur and that when this threshold of testosterone is reached, additional amounts do not further increase the frequency, amplitude or rigidity of erections [105,106].…”

Section: Lipid-lowering Drugs As a Cause Of Ed The Effects Of Statinsmentioning

confidence: 99%

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Dyslipidemia as a Risk Factor for Erectile Dysfunction

Vrentzos¹,

Paraskevas²,

Mikhailidis

2007

CMC

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Erectile dysfunction (ED) is a common condition with a significant effect on quality of life. The prevalence of ED increases with age and other risk factors (hypertension, diabetes, smoking, coronary heart disease, dyslipidemia and depression). Nitric oxide (NO) activity is adversely affected, in penile and vascular tissue, by these risk factors. Endothelial dysfunction and a reduced generation or bioavailability of NO have emerged as major pathophysiological mechanisms in ED. Hyperlipidemia may impair erectile function by affecting endothelial and smooth muscle cells of the penis. Oxidized low-density lipoprotein is a causative factor for the impaired relaxation response of the corpus cavernosum. Elevated serum cholesterol and reduced high density lipoprotein cholesterol levels are associated with an increased risk of ED. It follows that treating dyslipidemia could have a beneficial effect on ED. Phosphodiesterase type 5 inhibitors are now considered as first line treatment for ED. There is evidence that statins improve responses to these drugs. ED is considered as a warning sign of silent or early vascular disease. The use of statins may be beneficial in these patients.

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Section: Lipid-lowering Drugs As a Cause Of Ed The Effects Of Statinsmentioning

confidence: 99%