Serum apoptotic marker M30 is positively correlated with early diastolic dysfunction in adolescent obesity

Abstract

Purpose Obesity in adolescence has been shown to be related to cardiac geometric and functional changes. Cardiac dysfunction in adults with obesity could be attributed to chronic low-grade inflammation, apoptosis of cardiomyocyte, and glucose metabolic disorder. The aforementioned association in adolescents with obesity have never been well studied. Our aim was to determine the types of cardiac dysfunction in adolescents with obesity and survey the association between cardiac dysfunction and chronic low-grade inflammation, apoptosis, and glucose dysregulation in adolescents with obesity. Methods Adolescents aged between 10 and 20 years were enrolled in this study. Body mass index, waist-to-hip ratio, blood pressure, glucose metabolism, and high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-α), and apoptosis marker M30 levels were measured. Echocardiographic indices were also measured. The association between serum biomarkers and echocardiographic function parameters was analyzed. Results Diastolic dysfunction was the major finding in the cardiac functional assessment. The main changes in glucose metabolism were elevated C-peptide level and insulin resistance. Hs-CRP, IL-6, and M30 levels also increased with adolescent obesity. M30 was the major biomarker that was highly correlated to diastolic dysfunction indices in adolescents with obesity. Conclusions Diastolic dysfunction was the main change in adolescent obesity. Insulin resistance, apoptotic marker M30, hs-CRP, and IL-6 were all elevated in adolescents with obesity. Only M30 was related to indices of left ventricular diastolic dysfunction among adolescents with obesity, rather than inflammation or insulin resistance.

Serum Level of Cytokeratin 18 (M65) as a Prognostic Marker of High Cardiovascular Disease Risk in Individuals with Non-Alcoholic Fatty Liver Disease

“…Apoptosis of cardiomyocytes is associated with both the aging process and chronic cardiac overload [50] and plays a substantial role in altering cardiac geometry and progressively deteriorating myocardial function, potentially leading to chronic cardiomyopathy and advanced heart failure [51]. A recent study reported that CK18 (M30) level was highly correlated to left ventricular (LV) diastolic dysfunction in adolescents with obesity [52], although CK18 (M65) had not been investigated. In addition, another study determined the relationship between the development of LV remodeling and CK18 (M30) but not CK18 (M65) in patients with anterior ST-segment elevation myocardial infarction [53].…”

Racial Differences in Left Ventricular Filling Pressure Following Acute Aerobic Exercise Between Chinese and Caucasians

“…This suggests the different change of LVFP between races may be caused by disproportionate changes in mitral annular eʹ velocity and mitral E velocity between CH and CA subjects following exercise. As previously reported, LV diastolic function and LVFP were associated with HR [39], hemodynamics [5,28,29], exercise capacity [17,24], LV deformation [33,43,45] and BMI [35,47]. We also investigated whether baseline HR, BP, aerobic capacity, DWS, and BMI might produce different influences on ΔE/eʹ between races.…”

Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans

“…K18 has been proposed as a biomarker for a range of liver conditions including acute liver failure and chronic liver diseases such as viral hepatitis, non-alcoholic fatty liver disease and liver cancer (Ku et al 2016). While an advantage of K18 as a biomarker is that it is an early marker of apoptosis/necrosis; a disadvantage is that it is also a biomarker for dysfunction in tissues other than the liver including the lung (Fu et al 2019;Levy et al 2019;Molnar et al 2019;Tajima et al 2019) (Yang et al 2019). Thus, a panel of 3 or 7 biomarkers may be advantageous over a single biomarker.…”