Serum arterial lactate at the time of admission as a predictor of mortality in patients admitted with severe sepsis and septic shock to an ICU

Santana, Adriell Ramalho; Amorim, Fábio Ferreira; Menezes, Bárbara Magalhães; Soares, Felipe Bozi; Araújo, Fernanda Vilas Bôas; Souza, Jacqueline Lima de; Araújo, Mariana Pinheiro Barbosa de; Santos, Louise Cristhine de Carvalho; Rocha, Pedro Henrique Gomes; Neto, Osvaldo Gonçalves da Silva; Filho, Guilherme Menezes de Andrade; Júnior, Pedro Nery Ferreira; Amorim, Alethea Patrícia Pontes; Biondi, Rodrigo Santos; Ribeiro, Rubens Antônio Bento

doi:10.1186/cc12947

Cited by 1 publication

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“…The study concluded that higher lactate levels correlated with higher morbidity and mortality. 17 In another randomized trial on 348 patients in sepsis admitted to a tertiary level hospital, 171 patients were subjected to 'lactate clearance' of 20% as the treatment goal while in the remaining 177, though lactate levels were measured, these were neither utilized to treat nor were known to the treating team. All patients entering the trial had elevated lactate level at admission.…”

Section: 13mentioning

confidence: 99%

Comparison of central venous oxygen saturation and serum lactate clearance as predictors of outcome in septic shock patients: a prospective control trial

Narula¹,

Singh²,

Adya

2018

Int J Res Med Sci

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Background: Sepsis is the leading causes of mortality and morbidity in ICU. Early recognition and intervention ensures speedy recovery and early discharge. It’s possible only if good predicting parameters indicating optimum resuscitation are available. Lactate level reduction and ScvO2 level in the jugular vein can be utilized as predictors.Methods: In this prospective study after applying exclusion inclusion criteria, 99 patients were selected and randomized into 2 groups. In one group reduction in lactate levels and in other ScVo2 levels were used as a predictor of resuscitation. Therapeutic interventions, Hospital stay, ICU Stay and 28-day mortality were compared in both groups. Statistical analysis was carried out by SPSS software.Results: On comparison of demographic profile, morbidity, SOFA score and hemodynamic parameters, there was insignificant difference (P >0.05). No significant difference in the number of vasopressors, Average Hospital or ICU Stay (Group A is 10.68±21.46 while Group B is 9.49±17.22) and 28-day mortality rate (in Gp A 60% vs group B 57.1) was observed. Mean crystalloids administered in group A was 4.93±1.11 liters, significantly more than group B i. e. 4.19±1.17 liters. (P<0.05) which was statistically significant.Conclusions: Although both parameters of resuscitation are used widely and sometimes simultaneously, in this study lactate and ScvO2 both used and compared in a similar set of patients, appeared to be equivocal in term of 28-day mortality, except the volume of crystalloids required was more in ScvO2 Group.

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Section: 13mentioning

confidence: 99%