Serum autoantibodies directed against transglutaminase-2 have a low avidity compared with alloantibodies against gliadin in coeliac disease

Gelderman, Kyra A.; Drop, Adriaan C.A.D.; Trouw, Leendert A.; Bontkes, Hetty J.; Bouma, Gerd; Hoogstraten, Ingrid M.W. van; Blomberg, B. Mary E. von

doi:10.1111/cei.12302

Cited by 6 publications

(4 citation statements)

References 32 publications

(55 reference statements)

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“…For example, avidities of anti-amyloid-b antibodies in Alzheimer's disease were characterized by lower avidities [34]. An interesting comparison between avidities of antibodies against recall antigens and autoantigens suggested that regulation of immune B cell response can differ [35][36][37]. While the avidities of autoantibodies against citrullinated and carbamylated proteins, or tranglutaminase-2 tend to be low, avidities against recall antigens, such as tetanus toxoid, diphtheria toxoid, or gliadin, can be high despite their low titre.…”

Section: Discussionmentioning

confidence: 99%

Avidity of anti-phospholipid antibodies in relation to their levels

Fialová

Kuchar

Petráčková

et al. 2020

cejoi

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Introduction: the heterogeneity of anti-phospholipid antibodies can be manifested not only in different antigenic specificities, but also in their avidities. the aim of the study was to investigate the relationship between anti-cardiolipin antibody (acL) igG avidities and levels within the range of their titres, from very low to high ones. Material and methods: We analyzed 78 serum samples from 60 patients by eLiSa with chaotropic agents, using urea concentration of 6 and 8 mol/l and single diluted serum samples. the changes of acL levels and avidities were explored during a long-term follow-up in 14 patients. Results: the avidities of acLs did not differ in the groups of patients classified according to acL levels. the higher avidity antibodies predominated in our patients and the fluctuation of avidities in the longitudinal follow-up did not show significant differences. no relationship between acL levels and their avidities was found. Conclusions: acL avidities seem to have no relationship with acL levels and high-avidity acLs; the potentially deleterious effects might be present also in patients with low and extremely low acL levels. avidity of acLs belongs to stable characteristics with insignificant changes in time.

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Section: Discussionmentioning

confidence: 99%

Avidity of anti-phospholipid antibodies in relation to their levels

Fialová

Kuchar

Petráčková

et al. 2020

cejoi

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“…On the contrary, most recently, a Spanish group, found that intestinal ϒδ+ intraepithelial lymphocyte cytometric pattern is more accurate than subepithelial deposits of anti -IgA-TG2 ABs for CD diagnosis [19]. Anti TG2 autoantibodies expose a lower avidity compared with alloantibodies directed against gliadin, indicating different regulation or site of initiation of these humeral response [20]. Finally, exploring the celiac antibody binding to TG2, a single conformational TG2 epitope contributed by three domains was described to be critical for the ABs binding and their effects [21].…”

Section: Anti Tg2 Abs Secretion Binding and Distributionmentioning

confidence: 99%

Transglutaminase 2 and Anti Transglutaminase 2 Autoantibodies in Celiac Disease and Beyond: Anti- Transglutaminase 2 Autoantibodies: Friends or Enemies

Lerner¹,

Neidhöfer²,

Tenbusch³

2015

Immunome Res

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Tissue transglutaminase is a multifunctional enzyme, exerting intra and extracellular, enzymatic and nonenzymatic, Ca 2+ dependent and independent functions. Its specific autoantibody, the anti transglutaminase2 autoantibody is multifunctional, affecting many of the enzyme activities. Most of them are due to loss of function, the minority being gain of function of the enzyme. No beneficial protective effects, but only pathogenic ones, were assigned to those celiac disease associated anti TG2 autoantibodies. Taken together, celiac antibodies could collectively promote small bowel intestinal or extraintestinal damage. Yet, most of the transglutaminase2 autoantibody activities where explored in vitro and ex-vivo, very few in animal model but none in vivo, in human. The celiac disease serum contains numerous antibodies, IgA-transglutaminase2 is only one of them and up till now, its differential role in celiac disease induction and maintenance is far from being unraveled. Unraveling them might open some new therapeutic strategies for celiac disease.

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“…It is assumed that the high affinity (avidity) complexes of antigen B-cell receptor (i.e., surface antibodies associated with signaling molecules) could promote an extrafollicular B-cell response leading to an increasing number of plasma cells secreting antigen-specific antibodies [75]. Interestingly, an extrafollicular response or a short-time germinal response is assumed in the development of specific B-cells producing the low avidity autoantibodies against the key autoantigen of celiac disease, i.e., tissue transglutaminase [76,77]. Unfortunately, the histological analysis of the small intestinal mucosa is not usually performed in a follow-up of these patients.…”

Section: The Possible Similarity Between Oat and Wheat Amylase/trymentioning

confidence: 99%

The Pros and Cons of Using Oat in a Gluten-Free Diet for Celiac Patients

et al. 2019

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A therapeutic gluten-free diet often has nutritional limitations. Nutritional qualities such as high protein content, the presence of biologically active and beneficial substances (fiber, beta-glucans, polyunsaturated fatty acids, essential amino acids, antioxidants, vitamins, and minerals), and tolerance by the majority of celiac patients make oat popular for use in gluten-free diet. The health risk of long-time consumption of oat by celiac patients is a matter of debate. The introduction of oat into the diet is only recommended for celiac patients in remission. Furthermore, not every variety of oat is also appropriate for a gluten-free diet. The risk of sensitization and an adverse immunologically mediated reaction is a real threat in some celiac patients. Several unsolved issues still exist which include the following: (1) determination of the susceptibility markers for the subgroup of celiac patients who are at risk because they do not tolerate dietary oat, (2) identification of suitable varieties of oat and estimating the safe dose of oat for the diet, and (3) optimization of methods for detecting the gliadin contamination in raw oat used in a gluten-free diet.

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Serum autoantibodies directed against transglutaminase-2 have a low avidity compared with alloantibodies against gliadin in coeliac disease

Cited by 6 publications

References 32 publications

Avidity of anti-phospholipid antibodies in relation to their levels

Avidity of anti-phospholipid antibodies in relation to their levels

Transglutaminase 2 and Anti Transglutaminase 2 Autoantibodies in Celiac Disease and Beyond: Anti- Transglutaminase 2 Autoantibodies: Friends or Enemies

The Pros and Cons of Using Oat in a Gluten-Free Diet for Celiac Patients

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