Serum Beta-2-Microglobulin Level and Residual Renal Function in Peritoneal Dialysis

Amici, Gianpaolo; Virga, Giovambattista; Rin, Giorgio Da; Grandesso, Stefano; Vianello, A.; Gatti, Pier Luigi; Bocci, C

doi:10.1159/000187533

Cited by 45 publications

(33 citation statements)

References 3 publications

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“…Apart from removal of small molecular toxins, RRF contributes significantly to the clearance of middle and large molecular weight substances in PD patients 18 . Indeed, patients on PD with RRF have lower levels of β2‐microglobulin than those without RRF 19 …”

Section: Discussionmentioning

confidence: 99%

Comparison of residual renal function in patients undergoing twice‐weekly versus three‐times‐weekly haemodialysis

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Comparison of residual renal function in patients undergoing twice‐weekly versus three‐times‐weekly haemodialysis

et al. 2009

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“…RRF is associated with lower levels of middle molecules in PD (63–67) and HD (65,68). Clear evidence already exists that β 2 ‐microglobulin is a major constituent in dialysis‐related amyloid fibrils (69,70), and it has been suggested that RRF may protect against amyloid deposition (71).…”

Section: Potential Explanations For the Survival Benefit Associated Wmentioning

confidence: 99%

Emerging Importance of Residual Renal Function in End‐Stage Renal Failure

Vilar

Farrington

2011

Seminars in Dialysis

108

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Residual renal function (RRF) is well recognized as an important marker of outcomes in peritoneal dialysis (PD), and contributes vitally to solute clearance. Recently, its importance in hemodialysis (HD) has emerged with evidence that it is strongly associated with improved outcomes. The presence of RRF is associated with improved nutrition, reduced erythropoetin requirements, better potassium clearance, and improved quality of life. Retrospective and observational evidence is now available, which suggests that the presence of RRF is independently associated with survival and that this benefit goes beyond what is expected simply from augmentation of small solute clearance. Preservation of RRF is now considered by many to be an important aspect of dialysis strategy. Evidence in favor of one modality over another for preservation of RRF is conflicting, as are the potential benefits of biocompatible fluids in PD. In HD, the evidence in favor of biocompatible membranes is stronger. Emerging evidence is broadly in favor of angiotensin converting enzyme inhibitors for preservation of RRF. Diuretics appear to have a neutral effect. The complexities and practical difficulties in measurement of RRF have resulted in this important parameter being largely ignored in HD. Novel markers of renal function may provide alternative, simple methods of estimating RRF, which may remove the need for urine collections and simplify its measurement.

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“…β2‐microglobulin, advanced glycation end products (AGE), and advanced oxidised protein products (AOPP). RRF is also associated with better phosphate and potassium control, better anaemia correction and reduced erythropoietin stimulating agent consumption, improved nutritional status and quality‐of‐life, enhanced metabolic profiles (reduced internal milieu fluctuations) and improved dialysis patient outcomes 17–24 …”

Section: Is Preservation Of Residual Renal Function a Primary Objectimentioning

confidence: 99%

Residual renal function and dialysis modality: Is it really beneficial to preserve residual renal function in dialysis patients? (Review Article)

Canaud

Chénine²,

Leray‐Moragues³

et al. 2006

Nephrology

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SUMMARY:Residual renal function (RRF) contributes to the achievement of treatment adequacy in stage 5 chronic kidney disease (CKD-5) patients. It may facilitate patients' acceptance of renal replacement therapy (RRT) in allowing reduction of treatment time duration and minimising dietary and fluid restriction. It has been confirmed to improve dialysis patient outcomes. Attempts to preserve RRF in incident Stage 5 chronic kidney disease patients are still subject to intense controversies in the nephrology community. The aim of this review is to analyse the role of renal replacement modalities in the maintenance of RRF in dialysis patients. Under the scope of this manuscript, four questions are explored: Is the preservation of residual renal function an objective for dialysis adequacy? Does dialysis modality affect the decline of RRF? What are the factors implicated by this loss of RRF? At what expense can the maintenance of RRF be achieved in dialysis patients? Preservation of RRF is undoubtedly an interesting means to enhance the efficacy of renal replacement therapy and reduce dietary fluid restriction but it should not be considered as a goal of dialysis adequacy in dialysis patients. Further, preservation of RRF must be considered as a permanent trade-off between patient comfort and chronic fluid volume overload.

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Serum Beta-2-Microglobulin Level and Residual Renal Function in Peritoneal Dialysis

Cited by 45 publications

References 3 publications

Comparison of residual renal function in patients undergoing twice‐weekly versus three‐times‐weekly haemodialysis

Comparison of residual renal function in patients undergoing twice‐weekly versus three‐times‐weekly haemodialysis

Emerging Importance of Residual Renal Function in End‐Stage Renal Failure

Residual renal function and dialysis modality: Is it really beneficial to preserve residual renal function in dialysis patients? (Review Article)

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