Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

Järnfelt-Samsioe, Ann; Eriksson, Bo; Waldenström, J; Samsioe, Göran

doi:10.1159/000298949

Cited by 18 publications

(4 citation statements)

References 17 publications

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“…Our results are in agree with Bacq et al, (1996);Järnfelt-Samsioe et al, (1986); Knopp et al, (1985) indicated that total bilirubin concentration are decreased during all three trimesters of pregnancy.…”

Section: Resultssupporting

confidence: 93%

Evaluation of some Liver Function Tests During Different Gestational Period

Al-Hamdani¹,

Al-Doski²

2012

RJS

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This study was designed to assess the effect of pregnancy on liver function tests (LFTs) and to identify the variations between these LFTs during different gestational period. The present study include seven parameters: serum liver enzymes (AST, ALT, ALP, AST/ALT ratio) and bilirubin (total, direct and indirect) had been measured in blood of 50 healthy nonpregnant women, their age was ranged between (17-40) years as a control group and in 150 apparently healthy pregnant women their aged between (16-41) years. Pregnant women were divided into three subgroups according to their gestational period: 1 st , 2 nd and 3 rd trimesters (50 pregnant for each trimester of pregnancy). The results recorded a non significant difference in AST activity in all trimesters compared with control group, while serum ALT activity showed a significant reduction during pregnancy trimesters as compared with control group. The serum ALP activity show a significant increase as gestational period progress. However, the result of AST/ALT ratio showed no significant difference with the increase in the gestational period. Finally, serum total, direct and indirect bilirubin were all non significantly difference in all trimesters when compared with control (except the significant decrease in the comparison of total bilirubin in the 3 rd trimester with control group).

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Section: Resultssupporting

confidence: 93%

Evaluation of some Liver Function Tests During Different Gestational Period

Al-Hamdani¹,

Al-Doski²

2012

RJS

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“…The increase was insignificant (p>0.05) in the 1 st and 2 nd trimesters compared to nonpregnant women (p>0.05). This is in agreement with other studies, which have shown a slight increase in ALT and or AST in the third trimester of pregnancy [26][27][28]. An increase in ALT or AST levels prior to labour might be due to contractions of the uterine muscles [29].…”

Section: Discussionsupporting

confidence: 93%

Assessment of Liver Enzymes in Pregnant Women Attending Antenatal Clinic in Ikere-Ekiti

A.E¹,

O.D²,

Oludare³

et al. 2022

AMCRCS

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Pregnancy is a physiological condition which brings about changes in different systems of the body to support the growing foetus in the uterus. This study was designed to evaluate some of the liver enzymes (AST, ALT, ALP and GGT) activities in the different trimesters of pregnancy. A total of 120 subjects consisting of ninety [90] pregnant women at different trimesters thirty [30] and apparently healthy non-pregnant women (control) in Ikere-Ekiti [30] were recruited for this study. Blood samples were collected from the subjects after obtaining their consents. Liver function enzymes assay were determined using kinetic methods. Data analysis was done using SPSS computer software version 21.0 and results were presented in tables and figures as mean ± standard deviation. The result showed that the mean AST of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters were 3.44±1.88, 12.60±5.34, 10.20±4.93 and 8.67±3.37 (IU/L) respectively. The mean ALT of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters were 3.27±1.75, 14.56±8.71, 11.46±6.08 and 9.33±6.34 (IU/L) respectively. The mean GGT of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters was 3.60±1.88, 15.14±9.11, 13.22±5.27 and 10.35±7.19 (IU/L) respectively. The mean ALP of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters was 24.63±10.84, 58.73±24.71, 69.55±25.13 and 82.31±35.69 (IU/L) respectively. The study concludes that there was no significant difference (p>0.05) in the mean ALT, AST and GGT of pregnant women (subjects) in the three trimesters compared to non-pregnant women (control). However, there was significant difference (p<0.05) in the ALP of pregnant women in the 3rd trimester compared to non-pregnant women (control). Liver function tests are important biomedical indicators that reflect any changes in an adult person, and should be routinely investigated during pregnancy to outline any pathologic changes.

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“…A significant decrease in serum GGT activity was also found in late pregnancy compared with early pregnancy in women with morning sickness. 18 Our study showed that on change in prothrombin time from first trimester to third trimester of normal pregnancy, there was no significant change between the two trimesters. In a study by Olorunshola et al, the result of PT showed no statistically significant difference in the first and third trimesters except in the second trimester.…”

Section: Discussionmentioning

confidence: 49%

Liver function tests in first and third trimesters of normal pregnancy in a population of North Kerala

Venugopal¹,

Rajamma²

2016

JMD

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The aim of the study was to compare the first and third trimester variations of liver function tests during normal pregnancy in the age group of 20 to 30 years. It was a comparative prospective study wherein 100 pregnant women attending outpatient department for routine antenatal checkup were included. History was taken and general physical examination, systemic examination, routine investigations and liver functions tests were performed. Liver function tests were performed by an autoanalyzer. Analysis was done using student's t-test. P-value less than 0.05 was taken as significant. The serum total bilirubin, direct bilirubin, indirect bilirubin, aspartate amino transferase, total protein, albumin, globulin and gamma glutamyl transferase levels were higher in the first trimester when compared to the third trimester. The serum alanine amino transferase and alkaline phosphatase levels were higher in the third trimester when compared to the first trimester. There was not much significant difference between the A/G ratio and serum prothrombin levels in first trimester compared to that of third trimester. The decrease in total bilirubin, direct bilirubin, indirect bilirubin, total proteins, albumin and globulin were due to a phenomenon called hemodilution. The decrease in gamma glutamyl transferase could be due to the effect of hormones, oestrogen and progesterone which increases during pregnancy. Alkaline phosphatase levels increase by third trimester due to placental synthesis. Prothrombin time does not show any change in both the trimesters which shows that pregnancy has no effect on prothrombin time.

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Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

Cited by 18 publications

References 17 publications

Evaluation of some Liver Function Tests During Different Gestational Period

Evaluation of some Liver Function Tests During Different Gestational Period

Assessment of Liver Enzymes in Pregnant Women Attending Antenatal Clinic in Ikere-Ekiti

Liver function tests in first and third trimesters of normal pregnancy in a population of North Kerala

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