Serum bilirubin and the risk of rheumatoid arthritis

Du, Jing; Yuan, Yuan; Chen, Shiyong; Li, Jun; Xiuxiu, Zhou; Hu, Yan; Shi, Jianfeng; Shen, Bo

doi:10.1002/jcla.22118

Cited by 27 publications

(32 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total bilirubin acts as a protective factor for RA risk, it gets rid of peroxyl radicals and decreases oxidative stress [27]. This study agreement with studies [27,28].…”

Section: Ra Patient Group N=80 Control Group N=30 P Valuesupporting

confidence: 88%

See 1 more Smart Citation

Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

Hussain

Al-Hashemi

2018

JNUS

View full text Add to dashboard Cite

Oxidative stress is an imbalance between oxidants and antioxidants, play an important role in the development of Rheumatoid Arthritis. Rheumatoid Arthritis regard as a chronic, autoimmune disease. The aim of the study to assess levels of some oxidative stress biomarker in Rheumatoid Arthritis. This study involves 80 Rheumatoid arthritis patients and 30 healthy subjects as control groups. Analysis on serum samples was Malondialdehyde, Albumin, and total Bilirubin. The obtained data showed significantly increasing (P<0.01) in level of oxidant parameter Malondialdehyde and significantly decrease (P<0.01) in endogenous antioxidant albumin and total bilirubin in comparison with the control group which may be due to increased activity of immune system which involves reactive oxygen species in its action. The reactive oxygen species of originated from the immune system have the crucial role in oxidative stress situation in Rheumatoid arthritis.

show abstract

“…Total bilirubin acts as a protective factor for RA risk, it gets rid of peroxyl radicals and decreases oxidative stress [27]. This study agreement with studies [27,28].…”

Section: Ra Patient Group N=80 Control Group N=30 P Valuesupporting

confidence: 88%

“…Total bilirubin is a powerful antioxidant that could prevent lipid oxidation and other kinds of oxidation [16] total Bilirubin with regard to RA risk plays protective effect by getting rid of peroxyl radicals [28].…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

Hussain

Al-Hashemi

2018

JNUS

View full text Add to dashboard Cite

show abstract

“…The results from our study are likely suggesting that low total serum bilirubin is inflammation-mediated rather than contributing to the disease process. This is not a phenomenon specific only to IBD as various other inflammatory diseases, including psoriasis vulgaris [ 22 ], nonalcoholic steatohepatitis and advanced fibrosis [ 23 ], rheumatoid arthritis [ 24 , 25 ], and coronary artery disease [ 26 , 27 ], demonstrated lower levels of total serum bilirubin. In particular, patients with moderate to severe inflammation due to nonalcoholic steatohepatitis were found to have significantly lower levels of total serum bilirubin compared to those with absent to mild inflammation, suggesting that bilirubin levels may correlate with inflammation [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Reduced total serum bilirubin levels are associated with ulcerative colitis

et al. 2017

View full text Add to dashboard Cite

Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk for Crohn’s disease (CD). Therefore, the aim of this study was to examine whether total serum bilirubin levels are associated with ulcerative colitis (UC). We identified a retrospective case-control population (n = 6,649) from a single tertiary care center, Penn State Hershey Medical Center (PSU) and a validation cohort (n = 1,996) from Virginia Commonwealth University Medical Center (VCU). Cases were age- and sex-matched to controls (PSU: CD n = 254, UC n = 187; VCU: CD n = 233, UC n = 124). Total serum bilirubin levels were obtained from de-identified medical records and segregated into quartiles. Logistic regression analysis was performed on each quartile of total serum bilirubin compared to the last quartile (highest bilirubin levels) to determine the association of total serum bilirubin with UC. Similar to CD patients, UC patients demonstrated reduced levels of total serum bilirubin compared to controls at PSU and VCU. The lowest quartile of total serum bilirubin was independently associated with UC for the PSU (OR: 1.98 [95% CI: 1.09–3.63]) and VCU cohorts (OR: 6.07 [95% CI: 3.01–12.75]). Lower levels of the antioxidant bilirubin may reduce the capability of UC patients to remove reactive oxygen species leading to an increase in intestinal injury. Therapeutics that reduce oxidative stress may be beneficial for these patients.

show abstract

“…12,13 Recently, decreased levels of serum bilirubin have been linked to some connective tissue diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis (PM), the pathogenesis of which involves oxidative stress and inflammatory injury. [14][15][16][17][18][19] However, to our knowledge, there has been no study investigating whether serum bilirubin is decreased in pSS patients. Therefore, in this study, we aimed to determine the serum bilirubin levels in pSS patients and to explore clinical significance of bilirubin in pSS.…”

mentioning

confidence: 99%

Decreased Bilirubin is Associated With Disease Activity of Primary Sjögren's Syndrome

et al. 2020

View full text Add to dashboard Cite

Objectives: This study aims to determine the serum bilirubin levels in primary Sjögren's syndrome (pSS) patients and to explore clinical significance of bilirubin in pSS. Patients and methods: Retrospective analysis of electronic medical records was performed in 97 pSS patients (12 males, 85 females; mean age 54±15 years; range, 15 to 91 years) and 100 healthy controls (17 males, 83 females; mean age 51±14 years; range, 25 to 75 years). Serum bilirubin and other variables were compared between pSS patients and healthy controls. The European League Against Rheumatism Sjögren's syndrome disease activity index (ESSDAI) was used to assess the disease activity of pSS, and ESSDAI ≥5 was defined as moderate to high activity. The relationship between bilirubin and ESSDAI was analyzed by Spearman's correlation analysis and multivariable logistic regression. Results: The median level of serum bilirubin was 9 μmol/L (interquartile range (IQR), 7-13 μmol/L) in pSS patients, much lower than healthy controls (median, IQR, 13, 10-18 μmol/L) (p<0.001). It was positively correlated with age (r=0.255, p=0.012), but negatively with immunoglobulin (Ig) A (r=-0.314, p=0.003), IgG (r=-0.265, p=0.015), erythrocyte sedimentation rate (r=-0.309, p=0.002) and ESSDAI (r=-0.342, p=0.001). Multivariate analysis revealed that increased bilirubin was independently associated with decreased risk of moderate to high disease activity (odds ratio, 95% confidence interval: 0.852, 0.730-0.955). Conclusion: Serum bilirubin is decreased in pSS patients and may be a useful biomarker for reflecting pSS disease activity.

show abstract

Serum bilirubin and the risk of rheumatoid arthritis

Abstract: In conclusion, the levels of serum bilirubins were decreased in RA, and decreased levels could be associated with IgG, albumin and inflammatory marker ESR.

Cited by 27 publications

References 17 publications

Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

Reduced total serum bilirubin levels are associated with ulcerative colitis

Decreased Bilirubin is Associated With Disease Activity of Primary Sjögren's Syndrome

Contact Info

Product

Resources

About