Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients: A prospective study

Kuhlmann, Stella Linnea; Tschorn, Mira; Arolt, Volker; Beer, Katja; Brandt, Julia; Grosse, Laura; Haverkamp, Wilhelm; Müller‐Nordhorn, Jacqueline; Rieckmann, Nina; Waltenberger, Johannes; Warnke, Katharina; Hellweg, Rainer; Ströhle, Andreas

doi:10.1016/j.psyneuen.2016.12.015

Cited by 26 publications

(26 citation statements)

References 47 publications

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“…Moreover, met allele carriers exhibited higher remission rates after antidepressant treatment and were more vulnerable to persistent depression in longitudinally designed studies (Bozzini et al, 2009;Liu et al, 2014;Kang et al, 2016). In line with this finding, lower serum concentrations of BDNF appear to be associated with the persistence but not the incidence of depressive symptoms (Kuhlmann et al, 2017). The only other study to investigate BDNF blood concentration's role in the link between a cardiovascular disease (CHF) and depression failed to find an association between BDNF concentrations and depressive symptoms (Fukushima et al, 2015).…”

Section: Introductionsupporting

confidence: 55%

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Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease

Tschorn

Kuhlmann

Rieckmann

et al. 2020

Acta Neuropsychiatr.

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Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analyzed the relationship between BDNF and depression in a sample of patients with CHD, and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS), or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalized patients with CHD: BDNF concentrations, depression (Patient Health-Questionnaire-9), somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status, antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression: Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p=.04), this was not statistically significant after controlling for confounders (p=.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p=.08, p=.06, respectively). BDNF was reduced in patients with CHF (p=.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.

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Section: Introductionsupporting

confidence: 55%

“…A number of studies have examined BDNF's role in the relationship between CVD and depression (Bozzini et al, 2009;Liu et al, 2014;Kang et al, 2016;Kuhlmann et al, 2017, Han et al, 2019. It has been demonstrated that BDNF-related Val66Met polymorphism is involved in both depression and CHD.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease

Tschorn

Kuhlmann

Rieckmann

et al. 2020

Acta Neuropsychiatr.

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“…32 stroke and 17 MI studies (in 55 manuscripts) were included. Authors of 20 studies provided additional unpublished data (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55). The review process is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Treatment Rates of Depression After Stroke Versus Myocardial Infarction: A Systematic Review and Meta-Analysis of Observational Data

Ladwig

Zhou

et al. 2018

Psychosom Med

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“…Multiple imputation was performed to deal with missing data. Details have been described previously (Kuhlmann et al 2017). Statistical analyses were performed using IBM SPSS version 24 for Windows (SPSS Inc., Chicago, Illinois).…”

Section: Statistical Analysesmentioning

confidence: 99%

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

et al. 2020

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Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients' prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD.

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Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients: A prospective study

Cited by 26 publications

References 47 publications

Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease

Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease

Comparison of Treatment Rates of Depression After Stroke Versus Myocardial Infarction: A Systematic Review and Meta-Analysis of Observational Data

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

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