Serum butyrylcholinesterase and zinc in breast cancer

Kumar, Rupesh; Razab, Sairoz; Prabhu, Krishnananda; Ray, Sujoy; Prakash, Bhanu

doi:10.4103/0973-1482.165869

Cited by 25 publications

(2 citation statements)

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“…In more than 10% of the population, intake of zinc with meals is less than half the recommended dose, and chronic zinc deficiencies significantly increase the risk of cancer [10,12,13]. Many patients with cancer, especially of the lungs, breast, head, and neck, have a decreased level of zinc in the blood [14,15,16,17,18,19,20,21,22]. Due to the multitude of functions performed by this element, it can be assumed to play a leading role in defending against the initiation and promotion of tumors, although the mechanism of this role is not fully known [23].…”

Section: Introductionmentioning

confidence: 99%

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

2019

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The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, e.g., through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common around the world. Many epidemiological studies have shown a relationship between the zinc content in the diet and the risk of cancer. The anti-cancer effect of zinc is most often associated with its antioxidant properties. However, this is just one of many possibilities, including the influence of zinc on the immune system, transcription factors, cell differentiation and proliferation, DNA and RNA synthesis and repair, enzyme activation or inhibition, the regulation of cellular signaling, and the stabilization of the cell structure and membranes. This study presents selected issues regarding the current knowledge of anti-cancer mechanisms involving this element.

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Section: Introductionmentioning

confidence: 99%

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

2019

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“…True cholinesterase is found in the central nervous system, muscles, and in erythrocytes. Pseudocholinesterase is an alpha-glycoprotein found in the central and peripheral nervous system, in most tissues, and in liver [14]. Serum ChE level is decreased in several conditions such as acute and chronic liver damage, cirrhosis, inflammation and organophosphate exposure [13].…”

Section: Discussionmentioning

confidence: 99%

Serum Pseudocholinesterase as a Biomarker in the Differentiation between Gastric Cancer and Benign Gastric Diseases

Shaqi,

Rijub-Agha,

Hussain

2023

Al-Kindy Col. Med. J

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Background: Worldwide gastric cancer is the fifth most common cancer with poor prognosis. In early stages, it is hard to distinguish gastric cancer from benign gastric diseases, resulting in delayed diagnosis. There is a need to develop a biomarker for differentiating between gastric cancer and benign gastric diseases. Serum cholinesterase is synthesized in liver and released into plasma, and it has an important role in oncogenesis. Objectives: To determine the correlation between serum cholinesterase activity and gastric cancer, in comparison to benign gastric diseases. Subjects and Methods: A case control study carried out at Medical City Directorate\ Gastroenterology, Hepatology Hospital, and at Oncology Teaching Hospital from April 2022 to September 2022. It involved 25 patients with gastric cancer and age matched 25 patients with benign gastric diseases. Serum cholinesterase activity was determined by a colorimetric method.. Results: There was a significant difference in the mean level of serum cholinesterase between gastric cancer group (5339.28 U/L±1816) and benign gastric diseases group (7516.92 U/L±2351) with (P value<0.001). Significant association between low levels of serum cholinesterase and early cancer stages and grades (P value<0.001). Serum cholinesterase showed 60% sensitivity and 80% specificity in differentiating between gastric cancer and benign gastric diseases with optimal cutoff value of 5568U\L. Conclusions: Serum cholinesterase can be considered as a potential rapid and non-invasive biomarker for differentiating between gastric cancer and benign gastric diseases.

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The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Tehrani

Hosseini

Yousefi

et al. 2018

J of Cellular Biochemistry

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DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell‐cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer.

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Serum butyrylcholinesterase and zinc in breast cancer

Abstract: Both BChE and Zn are inexpensive and can easily be analyzed and may play a role in the management of breast cancer.

Cited by 25 publications

References 1 publication

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Serum Pseudocholinesterase as a Biomarker in the Differentiation between Gastric Cancer and Benign Gastric Diseases

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

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