Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

Içağasioğlu, Dilara; Çaksen, H; Sütçü, İdris; Cevit, Ömer

doi:10.14712/18059694.2019.65

Cited by 4 publications

(4 citation statements)

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“…Especially serial measurements of CRP are highly specific and sensitive in newborn sepsis [12–16]. Also, our results showed that CRP is the best sensitive and specific acute phase reactant for diagnosis of NLS.…”

Section: Discussionmentioning

confidence: 71%

“…Although, in recent years, several new markers of infection have been investigated, some studies suggested that CRP remains to be the best diagnostic test for neonatal sepsis. Especially serial measurements of CRP are highly specific and sensitive in newborn sepsis [ 12 – 16 ]. Also, our results showed that CRP is the best sensitive and specific acute phase reactant for diagnosis of NLS.…”

Section: Discussionmentioning

confidence: 99%

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Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

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AKŞİT

et al. 2008

Mediators of Inflammation

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Background. Sepsis is an important cause of mortality in newborns. However, a single reliable marker is not available for the diagnosis of neonatal late-onset sepsis (NLS). The aim of this study is to evaluate the value of serum amyloid A (SAA) and procalcitonin (PCT) in the diagnosis and follow-up of NLS. Methods. 36 septic and healthy newborns were included in the study. However, SAA, PCT, TNF-α, IL-1β, and CRP were serially measured on days 0, 4, and 8 in the patients and once in the controls. Töllner's sepsis score (TSS) was calculated for each patient. Results. CRP, PCT, and TNF-α levels in septic neonates at each study day were significantly higher than in the controls (P = .001). SAA and IL-1β levels did not differ from healthy neonates. The sensitivity and specificity were 86.8% and 97.2% for PCT, 83.3% and 80.6% for TNF-α, 75% and 44.4% for SAA on day 0. Conclusion. Present study suggests that CRP seems to be the most helpful indicator and PCT and TNF-α may be useful markers for the early diagnosis of NLS. However, SAA, IL-1β, and TSS are not reliable markers for the diagnosis and follow-up of NLS.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Uçar

Yıldız

AKŞİT

et al. 2008

Mediators of Inflammation

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“…Bazı çalışmalarda sepsisli hastalarda kan kültürü pozitifliği için %6 ile %82 gibi çok farklı sonuçlar bildirilmiştir [9]. Ülkemizde yapılan çalışmalarda; Yıldız ve arkadaşları [14] %65, İçağasıoğlu ve arkadaşları [17] %46,7, Gürsu ve arkadaşları [18] %48,3 kan kültüründe üreme olduğunu göstermişlerdir. Bizim çalışmamızda klinik sepsis tanısı almış hastalarda kültür ile kanıtlanmış sepsis sıklığı %38 bulundu.…”

Section: Discussionunclassified

Yenidoğan yoğun bakım ünitesindeki kültür ile kanıtlanmış sepsisli hastaların değerlendirilmesi

Kara¹,

Ertuğrul²,

Gundogus³

et al. 2015

Dicle Med J

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Objective: Despite in diagnosis, treatment and the development of the neonatal intensive care, neonatal sepsis continues to be an important cause of morbidity and mortality. In this study, we aimed to evaluate that having followed and treated in neonates with culture-proven sepsis.Methods: Between September 2012 -2014, the retrospective analysis was performed in the diagnosis of neonatal patients with culture-proven sepsis. For this purpose, 52 patients who had been diagnosed with cultureproven sepsis were admitted in the study. Results:The mean gestational age of patients was 32,75±1,45 weeks, and the average weight was 1895±516,49 grams. The patients were 35 (67.3%) premature and 17 (32.7%) term newborn. From sum of 1641 patients in our study had been diagnosed with sepsis 137 patients (8%), and 52 of them (3.2%) had a diagnosis of proven sepsis in patients with culture. Growth rate in culture for clinical sepsis patients were 38% (52/137). They were diagnosed 3 patients (5.8%) early neonatal sepsis and 49 (94,2%) patients late neonatal sepsis. Retraction was the most common finding 50% (26/52), bradycardia second 42.3% (22/52) and feeding intolerance the third 38.5% (20/52) were other common findings. The first three agents in positive blood cultures were Coagulasenegative staphylococci 46.1% (24/52), Klebsiella pneumoniae 21.2% (11/52) and Escherichia coli 9.6% (5/52). Conclusion:Blood culture results obtained may vary between units and also vary in sensitivity to antimicrobial therapy. Therefore, each unit should establish treatment strategies for sepsis in units according to the culture results are obtained. ÖZETAmaç: Yenidoğan yoğun bakım hizmetlerinin gelişmesine, tanı ve tedavideki ilerlemelere rağmen yenidoğan sepsisi önemli mortalite ve morbidite nedeni olmaya devam etmektedir. Bu çalışmada, takip ve tedavi ettiğimiz yenidoğanlarda görülen kültürle ispatlanmış sepsis olgularını değerlendirilmesi amaçlandı. Yöntemler: Çalışma Eylül 2012 -Eylül 2014 tarihleri arasında kültürle kanıtlanmış sepsis tanısı alan yenidoğan hastalarının retrospektif olarak incelenmesi ile yapıldı. Kültürle kanıtlanmış sepsis tanısı alan olan 52 hasta çalışmaya dahil edildi. Bulgular: Olgularımızın ortalama gebelik yaşı 32,75±1,45 hafta ve ağırlık ortalaması 1895±516,49 gramdı. Bunların 35'i (%67,3) prematüre ve 17'si (%32,7) term yenidoğandı. Çalışmadaki toplam 1641 hastadan 137'i (%8) klinik sepsis tanısı aldı, bunlardan ise 52 (%3,2) olguda kültür ile sepsisi tanısı kanıtlandı. Klinik sepsis tanısı alan olgularda kültür ile kanıtlanan sepsis sıklığı %38 (52/137) idi. Olguların 3'ü (%5,8) erken yenidoğan sepsis ve 49'u (%94,2) da geç yenidoğan sepsis tanısı aldı. Bu olguların %50'de (26/52) retraksiyon en sık görülen, %42,3 (22/52) bradikardi ikinci ve %38,5 (20/52) beslenme intoleransı üçüncü en sık görülen bulguydu. Çalışmada %46,1 olgu (24/52) ile en fazla üreyen patojen Coagulase-negative staphylococci idi, ikinci en sık üreme %21,2 (11/52) ile Klebsiella pneumoniae ve üçüncü en sık üreme %9,6 (5/52) ile Escherichia coli ü...

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“…35 In contradiction, IL-6 has been reported to be higher, and WCC lower, in infants who died compared with survivors. 36 A reduced capacity to produce IL-10 has been observed in neonates and has been postulated to predispose neonates to organ damage in severe sepsis. 37 The present study is limited by small sample size and the difficulty in generalizing from our population to other population groups.…”

Section: Discussionmentioning

confidence: 99%

Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis

et al. 2008

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We compared the test characteristics of interleukin (IL)-1 beta, IL-6, IL-8, IL-10, IL-12(p-70), tumor necrosis factor-alpha (TNF-alpha), procalcitonin (PCT), C-reactive protein (CRP), and full blood count (FBC) in the diagnosis of neonatal sepsis. This prospective cohort study in the Neonatal Intensive Care Unit of Dunedin hospital of patients between July 1, 2002 and February 28, 2007 included 117 neonates commenced on antibiotics for 164 episodes of suspected sepsis. Blood cultures, FBC, CRP, IL-1 beta, IL-6, IL-8, IL-10, IL-12(p-70), TNF-alpha, and PCT were obtained at the time sepsis was first suspected and for the following 3 days. Receiver operator characteristics (ROC) plots and test characteristics were determined using culture-positive sepsis as the gold standard. At the time sepsis was first suspected, the most promising individual test was IL-12(p70) with an area under the curve (95% confidence interval [CI]) for the ROC of 0.74 (0.63 to 0.86), which (with a cutoff at 75 pg/mL) had a sensitivity (95% CI) of 28% (20 to 36%) and a specificity of 98% (96 to 100%). IL-10 had a sensitivity of 17% (10 to 23%) and a specificity of 99% (97 to 100%). IL-10 and IL-12(p70) are promising diagnostic tests that can be used to confirm sepsis in neonates.

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Serum C-Reactive Protein and Interleukin6 Levels in Neonatal Sepsis

Cited by 4 publications

References 13 publications

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Serum Amyloid A, Procalcitonin, Tumor Necrosis Factor‐α, and Interleukin‐1β Levels in Neonatal Late‐Onset Sepsis

Yenidoğan yoğun bakım ünitesindeki kültür ile kanıtlanmış sepsisli hastaların değerlendirilmesi

Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis

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