Serum C-reactive protein and problems of newborn infants

Ainbender, Eugene; Cabatu, Eresvita E.; Guzman, Delores M.; Sweet, Avron Y.

doi:10.1016/s0022-3476(82)80080-2

Cited by 86 publications

(48 citation statements)

References 4 publications

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“…Although serum cytokine levels may rise 12 to 48 h prior to the onset of sepsis symptoms (426) and have been found to be highly predictive of neonatal sepsis, cytokine testing is not routinely performed in most clinical chemistry laboratories. Serial measurements of CRP levels appear to have the best discriminatory value for predicting septicemia among the tests currently available in many hospital laboratories, and the ability to produce CRP does not appear to be affected by gestational age (8,377,426). Several studies have specifically addressed the utility of CRP screening in VLBW neonates, with the sensitivity of a CRP value greater than 1 mg/dl for blood culture-proven sepsis ranging from 48 to 63% when a single test is performed and from 84 to 90% when multiple CRP screens are performed over a 24-to 48-h period following onset of symptoms (77,487).…”

Section: Use Of Adjunct Laboratory Tests To Predict Septicemiamentioning

confidence: 99%

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

2004

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Twenty percent of very-low-birth-weight (<1500 g) preterm infants experience a serious systemic infection, and despite advances in neonatal intensive care and antimicrobials, mortality is as much as threefold higher for these infants who develop sepsis than their counterparts without sepsis during their hospitalization. Outcomes may be improved by preventative strategies, earlier and accurate diagnosis, and adjunct therapies to combat infection and protect the vulnerable preterm infant during an infection. Earlier diagnosis on the basis of factors such as abnormal heart rate characteristics may offer the ability to initiate treatment prior to the onset of clinical symptoms. Molecular and adjunctive diagnostics may also aid in diagnosing invasive infection when clinical symptoms indicate infection but no organisms are isolated in culture. Due to the high morbidity and mortality, preventative and adjunctive therapies are needed. Prophylaxis has been effective in preventing early-onset group B streptococcal sepsis and late-onset Candida sepsis. Future research in prophylaxis using active and passive immunization strategies offers prevention without the risk of resistance to antimicrobials. Identification of the differences in neonatal intensive care units with low and high infection rates and implementation of infection control measures remain paramount in each neonatal intensive care unit caring for preterm infants

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Section: Use Of Adjunct Laboratory Tests To Predict Septicemiamentioning

confidence: 99%

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

2004

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“…In the majority of published reports, upper limits for CRP during the neonatal period have been obtained from symptomatic uninfected patients (62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72). Thus there are few studies of upper limits for CRP in the healthy newborn (73)(74)(75)(76).…”

Section: Normal (And Abnormal) Ranges In the Newborn Infantmentioning

confidence: 99%

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge

et al. 2004

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“…[11,12] In a neonatal intensive care unit (NICU) population with wide ranging differences in age, CRP was increased in those with a history of PROM, fetal distress, and chorioamnionitis. [11][12][13] The maximum CRP response occurs around 24 hours after onset (day 1). C-reactive protein should therefore be used mainly in serial determinations.…”

Section: Discussionmentioning

confidence: 99%

Serum Interleukin-6 Levels In Differential Diagnosis Of Sepsis And Transient Tachypnea Of Newborn

Uraş¹,

Karadağ²,

Tonbul³

et al. 2009

TUTFD

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Objectives:The aim of this study was to evaluate the role of serum interleukin-6 (IL-6) levels in the differentiation of neonatal bacterial sepsis and TTN. Patients and Methods:The hospital records of 58 newborns with respiratory distress that were above 35 weeks of gestational age were investigated. Patients were divided into two groups. The infection group consisted of patients with proven sepsis and clinical sepsis and the remaining one was TTN group. Clinical findings and white blood cell count, serum C-reactive protein (CRP), IL-6 levels and the ratio of immature neutrophils to total neutrophils count (I/T) were recorded and were compared between the two groups.Results: Serum CRP and IL-6 levels were found higher than normal limits in both of the groups. However there was no significant difference between them. Duration of respiratory distress was longer and I/T ratio was significantly higher in the infection group than TTN group.Conclusion: I/T ratio and IL-6 may contribute to the early diagnosis of sepsis with respiratory symptoms in newborn but IL-6 alone can not distinguish TTN and sepsis.Key words: Interleukin 6; sepsis; newborn; transient tachypnea.Amaç: Bu çalışmanın amacı yenidoğanlarda serum interlökin 6 düzeyinin bakteriyel sepsis ve yenidoğanın geçici takipnesinin ayrımında rolünün araştı-rılmasıdır. Hastalar ve Yöntemler:Solunum sıkıntısı olan ve gestasyonel yaşı 35 haftadan büyük olan 58 yenidoğan çalışmaya alındı. Hastalar, kanıtlanmış veya klinik sepsisi olanlar ve yenidoğanın geçici takipnesi olanlar olmak üzere iki gruba ayrıldı. Klinik bulgular beyaz küre sayısı, C reaktif protein, serum IL-6 düzeyi, periferik yaymada immature nötrofil sayısının toplam nötrofil sayısına oranı kaydedilerek gruplar arasında karşılaştırıldı. Bulgular:Her iki grupta da serum CRP ve IL-6 düzeyleri normal limitlerden yüksek bulunmasına rağmen iki grup arasında fark yoktu. Solunum sıkıntı-sının süresi ve I/T oranı yenidoğanın geçici takipnesi olan grupta belirgin olarak fazla bulundu.Sonuç: IL-6 ve I/T oranı solunum sıkıntısı olan sepsisli yenidoğanların erken tanısı konusunda katkıda bulunurken IL-6 düzeyi tek başına yenidoğanlarda sepsis ve yenidoğanın geçici takipnesinde kullanı-lamaz.Anahtar sözcükler: İnterlökin 6; sepsis; yenidoğan; yenidoğanın geçici takipnesi.

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Serum C-reactive protein and problems of newborn infants

Cited by 86 publications

References 4 publications

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge

Serum Interleukin-6 Levels In Differential Diagnosis Of Sepsis And Transient Tachypnea Of Newborn

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