Serum C-reactive protein and the site of urinary tract infections

Hellerstein, Stanley; Duggan, Eileen; Welchert, Eleanor; Mansour, Fayzeh

doi:10.1016/s0022-3476(82)80229-1

Cited by 42 publications

(8 citation statements)

References 8 publications

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“…Our results also confirm the observation of Dinkel et al (2) who noted that CRP value <20μg/mL was suggestive of LUTI (2). Nevertheless, other studies have noted values of up to 30μg/mL in LUTI (20, 21). …”

Section: Discussionmentioning

confidence: 85%

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The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

et al. 2016

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Objective:To evaluate the role of renal ultrasound (RUS) and urinary IL-6 in the differentiation between acute pyelonephritis (APN) and lower urinary tract infection (LUTI).Patients and methods:This prospective study was carried out at the Pediatric and urology outpatient and inpatient departments of Cairo University Children's Hospital as well as October 6 University Hospital and it included 155 children between one month and fourteen years old with positive culture UTI. Patients were categorized into APN and LUTI based on their clinical features and laboratory parameters. Thirty healthy children, age and sex matched constituted the control group. Children with positive urine cultures were treated with appropriate antibiotics. Before treatment, urinary IL-6 was measured by enzyme immunoassay technique (ELISA), and renal ultrasound (RUS) was done. CRP (C-reactive protein), IL-6 and RUS were repeated on the 14th day of antibiotic treatment to evaluate the changes in their levels in response to treatment.Results:UIL-6 levels were more significantly higher in patients with APN than in patients with LUTI (24.3±19.3pg/mL for APN vs. 7.3±2.7pg/mL in LUTI (95% CI: 2.6-27.4; p<0.01). Similarly, serum CRP was more significantly higher in patients with APN than in children with LUTI (19.7±9.1μg/mL vs. 5.5±2.3μg/mL (p<0.01). IL-6 levels >20pg/mL and serum CRP >20μg/mL were highly reliable markers of APN. Mean renal volume and mean volume difference between the two kidneys in the APN group were more than that of the LUTI and control groups (P<0.001). Renal volume between 120-130% of normal was the best for differentiating APN from LUTI.Conclusions:RUS and urinary IL-6 levels have a highly dependable role in the differentiation between APN and LUTI especially in places where other investigations are not available and/ or affordable.

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Section: Discussionmentioning

confidence: 85%

“…Data from different studies support that elevated sCRP levels are useful for the discrimination between APN and LUTI in patients with distinct clinical signs of APN (18, 19). In the present study, the mean sCRP level in the APN group was significantly higher than that in LUTI as well as the control groups.…”

Section: Discussionmentioning

confidence: 99%

The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

et al. 2016

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“…In this study (17), they demonstrated that increased CRP values between 25 mg/l to 300 mg/l were found in all patients with pyelonephritis. In contrast, Hellerstein and coworkers (11) found that serum CRP concentrations were not accurate in localizing the site of UTI and dimercaptosuccinic acid (DMSA) renal scintigram is the test of choice to make diagnosis of pyelonephritis (18). Ayazi et al (19) found no significant correlation between renal parenchymal involvement and serum level of CRP.…”

Section: öZetmentioning

confidence: 98%

“…Measurement of CRP level has been advised for monitoring of disease processes and for diagnosis of pyelonephritis (10). Studies on the usefulness of CRP for the diagnosis of UTI have so far been confined to the study of school girls and determination the site of urinary tract infection (10,11).…”

Section: öZetmentioning

confidence: 99%

Analysis of C-reactive protein in pyelonephritis

Al-Nassary¹,

Ameen²,

Mahdi³

2011

Gaziantep Med J

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Urinary tract infection especially pyelonephritis is a common condition worldwide caused by different uropathogens. The hostresponse parameters like C-reactive protein (CRP) are important inflammatory markers and diagnostic tests. The aim of this study was to assess the usefulness of CRP in urinary tract infection-pyelonephritis caused by different bacteria for defining the urinary tract infection (UTI). A total of fifty patients with clinical symptoms of pyelonephritis referred to Al-Kindi Teaching Hospital (Baghdad, Iraq), were investigated from October 2009 to November 2009. Clean-catch midstream urine of the patients was collected. Urine specimens were cultured for isolation of the microbial agents of UTI. The isolated bacteria were identified using biochemical tests. CRP were assessed in relation to the inflammatory responses. The most common isolated bacteria were (40%), Enterobacter (20%) and Klebsiella (12%). The least frequent bacteria were (4%), (4%) and (4%). There was a significant difference (P<0.001) between systemic inflammatory responses (CRP) with urinary tract inflammatory response (pyuria). According to the findings of this study, CRP can be suggested as useful and valuable tests in pyelonephritis.

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“…Urinary tract infection (UTI) is a relatively common infective condition seen in women attending obstetric and gynecological departments. There are relatively few studies looking at serum CRP levels and its value in UTI (56–58). In one such study, patients with complicated UTI (pyelonephritis) had elevated CRP levels whilst all patients with uncomplicated UTI had lower CRP levels (56).…”

Section: Role Of Crp In Obstetrics and Gynecologymentioning

confidence: 99%

The role of C‐reactive protein in modern obstetric and gynecological practice

Azizia

Irvine

Coker

et al. 2006

Acta Obstet Gynecol Scand

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C-reactive protein is an acute phase protein widely used as an indicator of infectious or inflammatory conditions. Traditionally it has been used as an adjunctive test for inflammation and as a marker of disease activity. Though sensitive, its nonspecific nature imposes limitation on its clinical use. Currently C-reactive protein is used in the management of chorioamnionitis, preterm premature rupture of membranes, pelvic inflammatory disease, and urinary tract infection. Interestingly, several obstetric conditions such as pre-eclampsia and gestational diabetes are now known to have an underlying inflammatory basis and there is an emerging role of C-reactive protein testing in managing these diseases. Additionally C-reactive protein testing has an established place in management of several acute abdominal conditions. The aim of this paper is to review the place of C-reactive protein in modern obstetric and gynecological practice.

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Serum C-reactive protein and the site of urinary tract infections

Cited by 42 publications

References 8 publications

The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection

Analysis of C-reactive protein in pyelonephritis

The role of C‐reactive protein in modern obstetric and gynecological practice

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