Serum C reactive protein predicts humoral response after BNT162b2 booster administration

Salvagno, Gian Luca; Henry, Brandon Michael; Pighi, Laura; Nitto, Simone De; Lippi, Giuseppe

doi:10.1016/j.jinf.2022.04.015

Cited by 5 publications

(7 citation statements)

References 5 publications

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“…27,28 Firstly, we did not find any changes of WBC, neutrophils, and lymphocytes in vaccinated patients compared to not vaccinated ones (Table 2) suggesting an absence of vaccine-induced systemic inflammation. Salvagno et al found that higher serum CRP levels are associated with a higher response to BNT162b2 booster administration 29 ; however, we further did not find any correlation between time from vaccination, number of doses received, and CRP levels neither after stratifying for age nor for diagnosis (Fig. 2A,C).…”

Section: Discussioncontrasting

confidence: 80%

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Evaluation of serum and cerebrospinal fluid biomarkers after vaccination against SARS‐CoV‐2

Iacono

Piccoli

Aridon

et al. 2023

Ann Clin Transl Neurol

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Objective Vaccines are a major achievement of science, and new vaccines against SARS‐CoV‐2 are protecting the entire population from a life‐threatening infection. Although several neurological complications or worsening of pre‐existing neurological conditions after vaccination have been observed, whether a biological plausibility exist between new vaccines against‐SARS‐CoV‐2 and neurological consequences is unclear. The aim of this study is to evaluate whether vaccines against SARS‐CoV‐2 induce systemic or cerebrospinal fluid alterations in patients with neurological disorders. Methods Patients who underwent lumbar puncture (LP) between February 2021 and October 2022 were enrolled. Serum C‐reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), cerebrospinal fluid total protein content (CSF‐TPc), glucose CSF/serum ratio, number of CSF cells per cubic millimeter, and CSF neurofilament light chain (CSF‐NfL) were compared between unvaccinated and vaccinated patients. Results A total of 110 patients were included and fitted into three groups according firstly to vaccination status (vaccinated and unvaccinated) and then to time from last dose of vaccine to LP (within or after 3 months). TPc, CSF/SGlu ratio, number of cells per cubic millimeter, CSF‐NfL, CRP, and NLR were not different between groups (all p > 0.05), and also, they did not differ neither according to age nor diagnosis. No relevant differences between groups were also noticed when the at‐risk time window was set to 6 weeks. Interpretation No signs of neuroinflammation, axonal loss and systemic inflammation were found in patients with neurological disorders after anti‐SARS‐CoV‐2 vaccination compared with unvaccinated ones.

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Section: Discussioncontrasting

confidence: 80%

“…Salvagno et al. found that higher serum CRP levels are associated with a higher response to BNT162b2 booster administration 29 ; however, we further did not find any correlation between time from vaccination, number of doses received, and CRP levels neither after stratifying for age nor for diagnosis (Fig. 2A,C ).…”

Section: Discussioncontrasting

confidence: 80%

Evaluation of serum and cerebrospinal fluid biomarkers after vaccination against SARS‐CoV‐2

Iacono

Piccoli

Aridon

et al. 2023

Ann Clin Transl Neurol

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“…Moreover, among vaccinated subjects monitored after the second dose, those subjects showing a rapid IgG growth and a better kinetic pattern also had the highest CRP levels, considered as the best performers to anti-SARS-CoV-2 vaccination. The positive association between high CRP levels and postvaccination IgG response has also been confirmed in a detailed survey of healthcare workers after Pfizer/BioNTech vaccine (Salvagno et al, 2022a). The authors found a highly significant correlation between pre-booster serum CRP levels and post-booster anti-SARS-COV-2 spike trimeric-RBD IgG antibodies.…”

Section: Discussionmentioning

confidence: 65%

“…Moreover, though intriguing hypotheses and mechanisms have been proposed, specific research works addressing the relationships between the phenotypic ABO blood group and anti-SARS-CoV-2 vaccine response did not reach definite results ( Sgherza et al, 2022 ). Finally, positive associations between C-reactive protein (CRP) and immune response after SARS-CoV-2 infection or vaccine have been recently reported, hypothesizing basal or unresolved inflammation as causative reasons ( Salvagno et al, 2022a ; Gianfagna et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes

et al. 2022

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Background: Development and worldwide availability of safe and effective vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to fight severe symptoms of coronavirus disease 2019 (COVID-19) and block the pandemic have been a great achievement and stimulated researchers on understanding the efficacy and duration of different vaccine types.Methods: We investigated the levels of anti-SARS-CoV-2 antibodies (IgG) and neutralizing antibodies (NAbs) in 195 healthy adult subjects belonging to the staff of the University-Hospital of Ferrara (Italy) starting from 15 days up to 190 days (about 6 months) after the second dose of the BNT162b2 (Pfizer–BioNTech) mRNA-based vaccine (n = 128) or ChAdOx1 (AstraZeneca) adenovirus-based vaccine (n = 67) using a combined approach of serological and genomics investigations.Results: A strong correlation between IgG and NAb levels was detected during the 190 days of follow-up (r2 = 0.807; p < 0.0001) and was confirmed during the first 90 days (T1) after vaccination (r2 = 0.789; p = 0.0001) and 91–190 days (T2) after vaccination (r2 = 0.764; p = 0.0001) for both vaccine types (r2 = 0.842; p = 0.0001 and r2 = 0.780; p = 0.0001 for mRNA- and adenovirus-based vaccine, respectively). In addition to age (p < 0.01), sex (p = 0.03), and type of vaccine (p < 0.0001), which partially accounted for the remarkable individual differences observed in the antibody levels and dynamics, interesting genetic determinants appeared as significant modifiers of both IgG and NAb responses among the selected genes investigated (TP53, rs1042522; APOE, rs7412/rs429358; ABO, rs657152; ACE2, rs2285666; HLA-A rs2571381/rs2499; CRP, rs2808635/rs876538; LZTFL1, rs35044562; OAS3, rs10735079; SLC6A20, rs11385942; CFH, rs1061170; and ACE1, ins/del, rs4646994). In detail, regression analysis and mean antibody level comparison yielded appreciable differences after genotype stratification (P1 and P2, respectively, for IgG and NAb distribution) in the whole cohort and/or in the mRNA-based vaccine in the following genes: TP53, rs1042522 (P1 = 0.03; P2 = 0.04); ABO, rs657152 (P1 = 0.01; P2 = 0.03); APOE, rs7412/rs429358 (P1 = 0.0018; P2 = 0.0002); ACE2, rs2285666 (P1 = 0.014; P2 = 0.009); HLA-A, rs2571381/rs2499 (P1 = 0.02; P2 = 0.03); and CRP, rs2808635/rs876538 (P1 = 0.01 and P2 = 0.09).Conclusion: High- or low-responsive subjects can be identified among healthy adult vaccinated subjects after targeted genetic screening. This suggests that favorable genetic backgrounds may support the progression of an effective vaccine-induced immune response, though no definite conclusions can be drawn on the real effectiveness ascribed to a specific vaccine or to the different extent of a genotype-driven humoral response. The interplay between data from the polygenic predictive markers and serological screening stratified by demogeographic information can help to recognize the individual humoral response, accounting for ethnic and geographical differences, in both COVID-19 and anti-SARS-CoV-2 vaccinations.

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“…In turn, CRP was positively correlated with antibody titers in autoimmune disease but not in hematological disease. The correlation between CRP and anti-SARS-CoV-2 IgG in healthcare workers who received a BNT162b2 vaccine booster [ 29 ] and higher CRP levels may be associated with the humoral response against vaccination. In our study, patients with autoimmune disease had relatively low CRP levels (0.14 mg/dL [0.06–0.32]).…”

Section: Discussionmentioning

confidence: 99%

Humoral immune response against SARS-CoV-2 and polyethylene glycol elicited by anti-SARS-CoV-2 mRNA vaccine, and effect of pre-existing anti-polyethylene glycol antibody in patients with hematological and autoimmune diseases

Hori,

Shimizu,

Ando

et al. 2024

Heliyon

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Serum C reactive protein predicts humoral response after BNT162b2 booster administration

Cited by 5 publications

References 5 publications

Evaluation of serum and cerebrospinal fluid biomarkers after vaccination against SARS‐CoV‐2

Evaluation of serum and cerebrospinal fluid biomarkers after vaccination against SARS‐CoV‐2

Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes

Humoral immune response against SARS-CoV-2 and polyethylene glycol elicited by anti-SARS-CoV-2 mRNA vaccine, and effect of pre-existing anti-polyethylene glycol antibody in patients with hematological and autoimmune diseases

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