Serum C1q Levels Have Prognostic Value for Sepsis and are Related to the Severity of Sepsis and Organ Damage

Li, Huan; Chen, Juanjuan; Hu, Yuanhui; Cai, Xin; Tang, Dongling; Zhang, Pingan

doi:10.2147/jir.s322391

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…In our study, a strong association between C1QC and organ dysfunction is evidenced. In a recent study, Li et al [60] found that C1QC levels were significantly reduced in the serum of sepsis patients. This decrease was associated with a high AUC not only with higher mortality, but also with a higher SOFA score with an AUC for sepsis prognosis, higher SOFA and mortality.…”

Section: Complementmentioning

confidence: 96%

Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock

et al. 2022

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Introduction The search for new biomarkers that allow an early diagnosis in sepsis and predict its evolution has become a necessity in medicine. The objective of this study is to identify, through omics techniques, potential protein biomarkers that are expressed in patients with sepsis and their relationship with organ dysfunction and mortality. Methods Prospective, observational and single-center study that included adult patients (≥ 18 years) who were admitted to a tertiary hospital and who met the criteria for sepsis. A mass spectrometry-based approach was used to analyze the plasma proteins in the enrolled subjects. Subsequently, using recursive feature elimination classification and cross-validation with a vector classifier, an association of these proteins with mortality and organ dysfunction was established. The protein-protein interaction network was analyzed with String software. Results 141 patients were enrolled in this study. Mass spectrometry identified 177 proteins. Of all of them, and by recursive feature elimination, nine proteins (GPX3, APOB, ORM1, SERPINF1, LYZ, C8A, CD14, APOC3 and C1QC) were associated with organ dysfunction (SOFA > 6) with an accuracy of 0.82 ± 0.06, precision of 0.85 ± 0.093, sensitivity 0.81 ± 0.10, specificity 0.84 ± 0.10 and AUC 0.82 ± 0.06. Twenty-two proteins (CLU, LUM, APOL1, SAA1, CLEBC3B, C8A, ITIH4, KNG1, AGT, C7, SAA2, APOH, HRG, AFM, APOE, APOC1, C1S, SERPINC1, IGFALS, KLKB1, CFB and BTD) were associated with mortality with an accuracy of 0.86 ± 0.05, a precision of 0.91 ± 0.05, a sensitivity of 0.91 ± 0.05, a specificity of 0.72 ± 0.17, and an area under the curve (AUC) of 0.81 ± 0.08 with a confidence interval of 95%. Conclusion In sepsis there are proteomic patterns associated with organ dysfunction and mortality.

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Section: Complementmentioning

confidence: 96%

Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock

et al. 2022

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“… 10 Moreover, research has shown that C1q serves as a valuable marker for assessing the severity of sepsis and organ damage. 11 …”

Section: Introductionmentioning

confidence: 99%

Diagnostic and Prognostic Value of C1q in Sepsis-Induced Coagulopathy

Zhang,

Wang,

Kuang

et al. 2024

Clin Appl Thromb Hemost

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Early identification of biomarkers that can predict the onset of sepsis-induced coagulopathy (SIC) in septic patients is clinically important. This study endeavors to examine the diagnostic and prognostic utility of serum C1q in the context of SIC. Clinical data from 279 patients diagnosed with sepsis at the Departments of Intensive Care, Respiratory Intensive Care, and Infectious Diseases at the Renmin Hospital of Wuhan University were gathered spanning from January 2022 to January 2024. These patients were categorized into two groups: the SIC group comprising 108 cases and the non-SIC group consisting of 171 cases, based on the presence of SIC. Within the SIC group, patients were further subdivided into a survival group (43 cases) and non-survival group (65 cases). The concentration of serum C1q in the SIC group was significantly lower than that in the non-SIC group. Furthermore, A significant correlation was observed between serum C1q levels and both SIC score and coagulation indices. C1q demonstrated superior diagnostic and prognostic performance for SIC patients, as indicated by a higher area under the curve (AUC). Notably, when combined with CRP, PCT, and SOFA score, C1q displayed the most robust diagnostic efficacy for SIC. Moreover, the combination of C1q with the SOFA score heightened predictive value concerning the 28-day mortality of SIC patients.

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Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?

Tortosa-Carreres,

Cubas-Núñez,

Piqueras

et al. 2024

Journal of Neuroimmunology

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Serum C1q Levels Have Prognostic Value for Sepsis and are Related to the Severity of Sepsis and Organ Damage

Cited by 4 publications

References 42 publications

Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock

Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock

Diagnostic and Prognostic Value of C1q in Sepsis-Induced Coagulopathy

Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?

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