Serum CA 125 level as a predictor of peritoneal dissemination in patients with gastric carcinoma

Nakata, Bunzo; Chung, Kyukwang; Kato, Yasuyuki; Yamashita, Yoshito; Maeda, Kiyoshi; Onoda, Naoyoshi; Sawada, Tetsuji; Sowa, Michio

doi:10.1002/(sici)1097-0142(19981215)83:12<2488::aid-cncr12>3.0.co;2-1

Cited by 59 publications

(53 citation statements)

References 17 publications

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“…In previous studies, serum CA125 levels were shown to be elevated according to the degree of peritoneal dissemination with gastric cancer [9], and to be highly sensitive for predicting peritoneal metastasis [10,11]. Moreover, in one of these studies [11], the level of CA125 was correlated with survival, although the number of patients in the study was relatively low.…”

Section: Discussionmentioning

confidence: 91%

“…Of note, the presence of ascites is a key determinant of CA125 at diagnosis in ovarian cancer [20,21]. CA125 also exists in the mesothelial cells covering the peritoneum [22], which may explain CA125 elevation caused by peritoneal or endometrial inflammation other than cancer [9].…”

Section: Discussionmentioning

confidence: 99%

“…Serum CA125 levels are known to be elevated in peritoneal inflammation and in carcinomatosis, and are widely used in the diagnosis of ovarian cancer [7,8]. A significant relationship between CA125 and gastric cancer with peritoneal dissemination has been reported [9][10][11]. However, in these studies, the number of patients with peritoneal metastasis was relatively small.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

et al. 2011

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Background Serum tumor markers have been shown to correlate with the clinical status of patients with advanced gastric cancer. However, the clinical significance of each tumor marker in patients with peritoneal dissemination has not been fully verified. Methods Four serum markers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA125, and CA72-4, were periodically measured in 102 patients with peritoneal dissemination who received combination intravenous and intraperitoneal chemotherapy. The initial values at diagnosis and after treatment were analyzed in association with clinicopathological factors, response to chemotherapy, and overall survival. Results The sensitivities of CEA, CA19-9, CA125, and CA72-4 for peritoneal metastasis at the initial diagnosis were 19, 36, 46, and 45%, respectively. The CA125 level was significantly correlated with the degree of peritoneal dissemination and the existence of malignant ascites. Patients with ovarian metastasis showed significantly higher levels of CA72-4. The median survival time of patients with an elevated CA125 level was significantly shorter than that of patients with a normal CA125 level (36.7 vs. 16.6 months, p \ 0.001). Multivariate analysis showed that the degree of peritoneal metastasis and an elevated CA125 level were independent prognostic factors. Normalization of the CA125 level after 3 courses of chemotherapy was correlated with reduced ascites and improved survival.Conclusions Serum CA125 and CA72-4 are clinically useful markers in diagnosis, evaluating the efficacy of chemotherapy, and predicting the prognosis of patients with peritoneal dissemination. From an academic point of view, periodic measurements of these markers are warranted in gastric cancer patients with possible peritoneal dissemination.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

et al. 2011

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“…Four discussion points were evaluated for CEA, CA19-9, and CA72-4 from selected articles as follows: (1) positive rates, (2) clinicopathological significance, (3) prognostic impact, and (4) clinical impact during follow-up after surgery and/or during chemotherapy. Finally, we selected 10 other publications that focused only on AFP [51][52][53][54], CA125 [3,[55][56][57], and STN [58,59] (Fig. 1).…”

Section: Manuscript Selectionmentioning

confidence: 99%

“…The serum levels of CEA, CA19-9, and CA72-4 may be elevated in patients with gastric cancer at various stages [1]. AFP [2], CA125 [3], and STN [4] can be used to detect liver metastases and/or peritoneal metastases. However, low rates of sensitivity and specificity prevent the use of any of these serum markers in early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

et al. 2013

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The aim of this review was to evaluate the clinical significance of serum tumor markers, particularly CEA, CA19-9, and CA72-4, in patients with gastric cancer. A systematic literature search was performed using PubMed/MEDLINE with the keywords ''gastric cancer'' and ''tumor marker,'' to select 4,925 relevant reports published before the end of November 2012. A total of 187 publications contained data for CEA and CA19-9, and 19 publications contained data related to all three tumor markers. The positive rates were 21.1 % for CEA, 27.8 % for CA19-9, and 30.0 % for CA72-4. These three markers were significantly associated with tumor stage and patient survival. Serum markers are not useful for early cancer, but they are useful for detecting recurrence and distant metastasis, predicting patient survival, and monitoring after surgery.

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Prognostic factors associated with the survival of patients with gastric adenocarcinoma: A retrospective study

Chen

Feng

et al. 2020

Adv in Digestive Medicine

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Gastric cancer is one of the most common gastrointestinal malignancies and is a lethal cancer. This study aimed to assess the factors affecting the survival and benefit of various therapeutic modalities in gastric adenocarcinoma (GAC) patients. Between March 2006 and October 2015, 121 GAC cases were identified by pathology and divided into groups I (surgery group; n = 41), II (IIa: 19 cases without treatment; IIb: 27 cases with palliative treatment), and III (combined surgery and postoperative chemotherapy; n = 34). Furthermore, the factors affecting early (12‐month) mortality and therapeutic outcomes between these groups were assessed over the study period. Patients who underwent treatment had longer survival than those who did not (groups I+IIb+III vs IIa, P < .001); group I provided the longest survival benefit among groups over the study period (Figure 2). Analyzing 12‐month mortality, significant differences were found in groups I vs IIa (P < .001), groups I vs IIb (P < .001), groups III vs IIa (P < .001), and groups III vs IIb (P < .001) in overall patients and in groups I vs IIa (P < .001), groups I vs IIb (P = .017), groups III vs IIa (P < .001), and groups III vs IIb (P < .001) in advanced‐stage patients (Table 2). Overall, the independent factors included advanced tumor stage (hazard ratio = 8.038, P = .007), absent treatment (hazard ratio = 14.009, P = .009), higher bilirubin (hazard ratio = 8.198, P = .047), and higher CEA (hazard ratio = 3.999, P = .030). Surgery provides better survival benefit, but palliative chemotherapy could also prolong unresectable GAC patients' survival. Factors of better liver preservation, lower carcinoembryonic antigen (CEA), and less aggressive tumor condition play crucial roles in predicting patients' survival.

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Serum CA 125 level as a predictor of peritoneal dissemination in patients with gastric carcinoma

Cited by 59 publications

References 17 publications

Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination

Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association

Prognostic factors associated with the survival of patients with gastric adenocarcinoma: A retrospective study

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