Serum Calcium and Cognitive Function in Old Age

Schram, Miranda T.; Trompet, Stella; Kamper, Adriaan M.; Craen, Anton J. M. de; Hofman, Albert; Euser, Sjoerd M.; Breteler, Monique M.B.; Westendorp, Rudi G.J.

doi:10.1111/j.1532-5415.2007.01418.x

Cited by 68 publications

(45 citation statements)

References 30 publications

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“…In the Rotterdam study on cognitive function in 3994 individuals between ages 55 and 90 years, high serum calcium was significantly associated with worse global cognitive function during a median follow-up of 11 years. 22 In the present study, high calcium levels in patients with pHPT correlated significantly with higher HADS depression scores, more severe depressive symptoms, and suicidal ideation on the PHQ-9, as well as reduced SF-36 mental health scores. No such correlation was seen in the control group.…”

Section: Commentsupporting

confidence: 59%

Parathyroidectomy, Elevated Depression Scores, and Suicidal Ideation in Patients With Primary Hyperparathyroidism

Weber

Eberle²,

Messelhäuser³

et al. 2013

JAMA Surg

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Section: Commentsupporting

confidence: 59%

Parathyroidectomy, Elevated Depression Scores, and Suicidal Ideation in Patients With Primary Hyperparathyroidism

Weber

Eberle²,

Messelhäuser³

et al. 2013

JAMA Surg

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“…The study results about the relationship between calcium and cognitive function are also inconsistent. High calcium levels have been reported to result in accumulation of calcium in brain cells and nerve cells, causing cell necrosis and adversely affecting cognitive function, whereas a large cohort study of 2,000 Chinese showed that the higher the calcium level, the better cognitive function [16,17]. In Korea, a study of 38 Alzheimer's patients aged 65 years or older reported that calcium had a negative effect on cognitive function [18].…”

Section: The Need For Researchmentioning

confidence: 99%

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

Lee

Kim²

2017

J Korean Acad Community Health Nurs

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Purpose: This study aims to examine the influence of vitamin D and calcium on depression and cognitive function of the elderly living alone in a city. Methods: The participants were registered in eight senior centers in S city and they had lived alone. Data were collected between November 28, 2014 and March 7, 2015. A total of 155 people participated in data collection to measure the serum vitamin D, the serum calcium, depression, and cognitive function. The data were analyzed with t-test, ANOVA, Pearson's correlation and multiple regression analysis. Results: There were significant differences in depression according to gender and perceptions of health status. Depression correlated significantly with the serum calcium and perceptions of health status, and a stepwise regression analysis showed that the perceptions of health status were significant. There were significant differences in cognitive function according to education level and age. Cognitive function correlated significantly with the serum vitamin D and a stepwise regression analysis showed that education level and age were significant. Conclusion: Consequently, elderly people with poor perceptions of their health status need a depressive intervention program and those with a higher age and lower level of education need a cognitive function intervention program.

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“…Further antioxidants may be also part of a functional neuroplastic diet, such as choline, combination of vitamins [C, E, carotene], calcium, selenium, zinc and creatine, which delay brain decline, promote longevity and cellular energetic nerve tissues storage and repair etc. [54][55][56][57][58].…”

Section: Other Antioxidant Nutrientsmentioning

confidence: 99%

Brain nutrition-orthomolecular aspects

Moya¹

2017

Integr Food Nutr Metab

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the "plastic" human and primate brain continue to make neurons in the cerebral cortex during lifespan [3,4]. The established "neurogenic" (originated active proliferative neural cells and growth factors) regions are the dentate gyrus of the hippocampus, the subventricular zone (the source of neocortical neurons in development), and the olfactory lobe [5,6]. In summary, the number of new neurons produced, matches the number of neurons lost in each area, but as soon as the dying cells are being faster removing from the brain´s regions, the physiologic balance will be lost and the cognitive and neurologic function will decline. As a relative new concept in neurosciences, the neuronal plasticity refers to changes at the neuronal level, known to be stimulated by experience, e.g., neurogenesis, synaptogenesis, dendritic arborization, and network re-organization [5]. Cognitive plasticity refers to changed patterns of cognitive behavior, e.g., greater susceptibility to distractors, and dependence on executive control, both increased in aging. Manifestations of cognitive plasticity depend upon neural plasticity mechanisms and in the absence of disease; factors that enhance this interactive process can promote both cognitive integrity (preserved cognitive ability) and brain integrity (preserved brain structure) in healthy old age [5]. During lifespan, the brain may adapt to stress by triggering several regenerative mechanisms, such as DNA repair, neurotrophic releasing, enzymatic antioxidant defense and synaptic reconnections [7][8][9]. Since the discovery of the adult neurogenesis, much research effort has been devoted to study its mechanisms and implications in healthy and pathological conditions. Some elucidated neurogenic mechanisms involve neurotransmitters (such as dopamine, AbstractThe contemporary advances in neuroscience and anti-aging medicine show that the brain and nervous system can adapt to chronic stress, inflammation and damage mechanisms by increasing its neurogenic and neuroplasticity potential. Neuroplasticity is the key point response of adaptation and repairing of functional neurons throughout life, giving the opportunity, either by DNA restoration, releasing of neurotrophins, antioxidant defences, mitochondrial, inflammatory and apoptotic regulation to fight against the neurological aging typical decline. The perfect neuroplastic development will depend on a multi imperative factors and concepts, such as epigenetics, dietary anti-inflammatory/antioxidant nutrition, caloric restriction, mindfulness meditation ability, novelties experiences, sleep cycle quality, exercise, physiological and psychological stress coping, hormonal balance and cellular or tissues regenerative molecules. The orthomolecular medicine establishes the use of the correct molecules to keep the perfect physiological and biochemical function of the body and by using this wide-range Linus Pauling definition this mini-review aims to address the main issues related to the mechanisms of cognitive and neuroplasticity development and off...

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Serum Calcium and Cognitive Function in Old Age

Abstract: In the general population, high serum calcium levels are associated with faster decline in cognitive function over the age of 75.

Cited by 68 publications

References 30 publications

Parathyroidectomy, Elevated Depression Scores, and Suicidal Ideation in Patients With Primary Hyperparathyroidism

Parathyroidectomy, Elevated Depression Scores, and Suicidal Ideation in Patients With Primary Hyperparathyroidism

The Effect of Vitamin D and Calcium on Cognitive Function and Depression in the Elderly Living in a City

Brain nutrition-orthomolecular aspects

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