Serum calcium levels are not associated with coronary heart disease

Jin, Yuelong; He, Lianping; Wang, Quanhai; Chen, Yan; Ren, Xiaohua; Tang, Hui; Song, Xiuli; Ding, Lingling; Qi, Qin; Huang, Zhiwei; Yu, Jiegen; Yao, Yanwen

doi:10.2147/vhrm.s49136

Cited by 4 publications

(3 citation statements)

References 24 publications

(20 reference statements)

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“…Additionally, they found a positive association between serum calcium and cardiovascular disease (10). In addition, Jin et al showed that serum calcium had no influence on coronary heart disease in the general population (15). Narang did not also find an association between serum calcium level and the angiographic severity in 376 stable patients with CAD (14), which was not in line with the results of the present study.…”

Section: Discussioncontrasting

confidence: 89%

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Correlation of Serum Calcium with Cardiovascular Outcome in Patients with Acute Coronary Syndrome

Wang

et al. 2021

ircmj

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Background: There have been no studies investigating the relationship between serum calcium level at admission and long-term cardiovascular outcome in patients with the acute coronary syndrome (ACS). Objectives: This study aimed to explore the correlation of admission serum calcium with cardiovascular outcome in ACS patients. Methods: This longitudinal study included 105 ACS or suspected ACS patients who were referred to the Coronary Care Unit between June 1st, 2015, and August 31st, 2016. Serum calcium was measured upon admission, and the patients were followed up till November 30th, 2016. Cardiovascular death or cardiovascular re-hospitalization was the study's end. Results: According to the median of serum calcium, the patients were divided into two groups of lower (n=47) and higher serum calcium (n=58). Kaplan-Meier analysis found that patients with lower serum calcium had an obviously reduced cardiovascular event-free survival (log-rank χ2=5.594, P=0.018), compared to those with higher serum calcium. Furthermore, lower serum calcium level (HR=0.265, 95% CI=0.072-0.981, P=0.047) independently correlated with poor cardiovascular outcome in ACS or suspected ACS patients after adjustment for potential confounders in the multivariable Cox model. Conclusion: Lower serum calcium upon admission independently correlated with poor long-term cardiovascular outcomes in patients with severe coronary artery disease.

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Section: Discussioncontrasting

confidence: 89%

“…On the other hand, calcium supplements with or without vitamin D showed no decrease; however, they modestly increased cardiovascular events, especially myocardial infarction (12,13). In addition, some studies revealed no correlation between serum calcium and cardiovascular event (14,15).…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum Calcium with Cardiovascular Outcome in Patients with Acute Coronary Syndrome

Wang

et al. 2021

ircmj

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“…Data obtained by other researchers also indicates that in arterial hypertension the concentration of total calcium in the blood plasma remains constant [11][12][13][14][15]. A correlation between hypertension and serum calcium has been studied in different ethnicities and races [9,[16][17][18][19]. At the same time, a study of calcium metabolism in the body of patients with arterial hypertension revealed changes already in the early stages of the disease.…”

Section: Discussionmentioning

confidence: 92%

Characteristics of calcium homeostasis in patients with different degrees of arterial hypertension

Keledzhyyeva

Kaliberdenko

Shterenshis

et al. 2020

Arterial Hypertension

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Background: Calcium is the most common cation in the human body. An abnormal distribution of intracellular and extracellular ionized Ca plays a significant role in the formation of arterial hypertension. The purpose of the study is to analyze the fractional composition of calcium in blood serum and urinary calcium excretion in patients with hypertension, as well as to identify the features of the distribution of these. Material and methods: The study included 80 patients. The population of the study consisted of 60 patients with various degrees of hypertension (38 women and 22 men) aged from 65 to 74 years old and the control group composed of 20 patients (12 men and 8 women) in the same age group without signs of hypertension. The patients with clinically expressed coronary heart disease requiring specific therapy, heart defects, impaired liver function and impaired kidney function were excluded from this study. Patients were divided into three groups, according to the World Health Organization (WHO) classification of arterial hypertension. Indicators of calcium concentration in blood and urine were determined using test kits for determining calcium with glyoxal bis-2 hydroxyanil from LACHEMA. To determine the ionized calcium, a standard technique of ion-selective electrode was used. Results and conclusion:1. In patients with arterial hypertension, a redistribution of the calcium pool in the blood is noted due to a decrease in the concentration of ionized calcium and an increase in the bound calcium, depending on the severity of the disease.2. An increase in urinary calcium excretion in patients with arterial hypertension is characteristic of moderate and severe forms of arterial hypertension, which given the age of patients, may be one of the causes of osteoporosis. 3. The increase in the level of intracellular calcium with the progression of arterial hypertension is an example of pathophysiological reactions that occur at the body level, the result of which can be not only banal muscle constriction but also a violation of the synthesis and production of biologically active substances that regulate blood pressure.

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Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score

Alsancak

Sivri

Baştuğ

et al. 2018

Archives of Clinical and Experimental Medicine

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of calcium-albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score. Arch Clin Exp Med. 2018;3(3):174-178. AbstractAim: Numerous studies have reported a relationship between serum calcium or albumin levels and acute coronary syndromes and coronary artery disease. The present study investigated the relation between serum albumin, calcium or albumin-corrected calcium levels or calcium/albumin ratio (CAR) and extensiveness and severity of atherosclerosis. Methods: This prospective study included patients with non-ST elevation myocardial infarction (NSTEMI, n=120) and a control group (n=109). We used the SYNTAX score to evaluate the association between CAR and severity and extent of coronary artery disease. Results: There were higher, but statistically nonsignificant, levels of calcium in patients with NSTEMI (p=0.058). However, serum albumin-corrected calcium levels were significantly higher in NSTEMI group (p=0.001). Yet, albumin levels did not differ between the groups (p=0.093). CAR and corrected calciumalbumin ratio (cCAR) were significantly higher in NSTEMI group (p=0.001). A positive correlation existed between CAR (r=0.235, p=0.010), cCAR (r=0.259, p=0.004), and SYNTAX score, whereas albumin and SYNTAX score (r=−0.259, p=0.004) showed a negative correlation. Conclusion: Calcium/albumin ratio has been found to be associated with an increased coronary atherosclerotic burden as calculated by SYNTAX score. Further large-scale studies are warranted to confirm our findings.Keywords: Non-ST elevation acute myocardial infarction, SYNTAX score, calcium-albumin ratio Öz Amaç: Serum kalsiyum ve albumin seviyeleri ile akut koroner sendromlar ve koroner arter hastalığı arasındaki ilişki birçok çalışmada gösterilmiştir. Sunulan çalışmada, serum albumin, kalsiyum, albumin-düzeltilmiş kalsiyum seviyeleri ve kalsiyum/albumin oranı (KAO) ile aterosklerozun yaygınlık ve ciddiyetinin ilişkisi araştırılmıştır. Yöntemler: Bu prospektif çalışmaya non-ST elevasyonlu miyokard infarktüsü olan hastalar (NSTEMI, n=120) ve kontrol grubu (n=109) dahil edildi. KAO ile koroner arter hastalığı yaygınlık ve ciddiyetinin ilişkisini değerlendirmek için SYNTAX skoru kullanıldı. Bulgular: NSTEMI hastalarında istatistiksel anlamlı olmadan daha yüksek kalsiyum seviyeleri vardı (p=0.058). Buna rağmen serum albumin-düzeltilmiş kalsiyum seviyeleri istatistiksel anlamlı olarak NSTEMI grubunda daha yüksekti (p=0.001). Albumin seviyeleri ise gruplar arasında farklılık göstermedi (p=0.093). KAO ve düzeltilmiş kalsiyum/albumin oranı (dKAO), NSTEMI grubunda anlamlı olarak daha yüksekti (p=0.001). KAO (r=0.235, p=0.010) ve dKAO (r=0.259, p=0.004) ile SYNTAX skoru arasında pozitif korelasyon mevcut iken, albumin ile SYNTAX skoru (r=−0.259, p=0.004) arasında negatif korelasyon görüldü. Sonuç: Kalsiyum/albumin oranı, SYNTAX skoru ile hesaplanan artmış koroner aterosklerotik yük ile ilişkili bulunmuştur. Bulgularımızı doğrulamak için daha geniş çaplı çalışmalar gereklidir.Anahtar kelimeler: Non-ST elevasyonlu akut miyokard infa...

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Serum calcium levels are not associated with coronary heart disease

Cited by 4 publications

References 24 publications

Correlation of Serum Calcium with Cardiovascular Outcome in Patients with Acute Coronary Syndrome

Correlation of Serum Calcium with Cardiovascular Outcome in Patients with Acute Coronary Syndrome

Characteristics of calcium homeostasis in patients with different degrees of arterial hypertension

Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score

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