Serum calprotectin as a biomarker for Crohn's disease

Meuwis, Marie‐Alice; Vernier-Massouille, G.; Grimaud, Jean–Charles; Bouhnik, Yoram; Laharie, David; Piver, Éric; Seidel, Laurence; Colombel, Jean–Frédéric; Louis, Édouard

doi:10.1016/j.crohns.2013.06.008

Cited by 123 publications

(113 citation statements)

References 11 publications

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“…Th e upper range of measurement for FCAL is 1,888 μ g per g stool. Participants were considered to have active intestinal infl ammation if FCAL exceeded 250 μ g per g stool ( 22,23 ). ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

The Relationship Among Perceived Stress, Symptoms, and Inflammation in Persons With Inflammatory Bowel Disease

Targownik

Sexton

Bernstein

et al. 2015

American Journal of Gastroenterology

134

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Symptomatic disease activity was unrelated to intestinal inflammation in CD and only weakly associated in UC. Although there was a strong relationship between perceived stress and gastrointestinal symptoms, perceived stress was unrelated to concurrent intestinal inflammation. Longitudinal investigation is required to determine the directionality of the relationship between perceived stress, inflammation, and symptoms in IBD.

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Section: Methodsmentioning

confidence: 99%

The Relationship Among Perceived Stress, Symptoms, and Inflammation in Persons With Inflammatory Bowel Disease

Targownik

Sexton

Bernstein

et al. 2015

American Journal of Gastroenterology

134

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“…For UC and CD children that do not respond to conventional therapies a clinical trial (Identifier: NCT02150551) has been initiated that will assess intravenously allogeneic bone marrow-derived mesenchymal stromal cells for their ability to locate inflammation, decrease pro-inflammatory cytokines and promote tissue repair. Moreover, new drugs and biomarkers are being tested in humans, such as AST-120 (Identifier: NCT00321412) and serum calprotectin (Meuwis et al 2013). Humanised monoclonal antibodies against cytokines, such as anti-IL-2 receptor are investigated against moderate to severe UC (Identifier: NCT00073047).…”

Section: Clinical Trialsmentioning

confidence: 99%

Parallels Between Mammals and Flies in Inflammatory Bowel Disease

Christofi

Apidianakis

2015

Life Extension

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The intestinal hologenome lies at the center of intestinal homeostasis and disease. It is the sum of the host genome and the intestinal microbiome. During the last decade we came to appreciate the pivotal role of the microbiome in intestinal inflammation and concomitant diseases. Moreover environmental factors, predominantly diet, affect the microbiome and the host immune responses. Thus manipulation of intestinal microbiota and environmental factors are rightfully the focus of current research. The study of the hologenome necessitates not only clinical assessments but also the use of model organisms, for example, mice and flies. Despite the limitations imposed by the evolutionary distance between flies and mammals, Drosophila research provided us during the last few years with a wealth of information regarding intestinal inflammation and the role of microbiota. Conserved aspects of intestinal homeostasis and disease between flies and mice, for example in signalling pathways, the intestinal defence responses and the role of microbiota, consolidate and may advance the principles that govern intestinal inflammation in humans.

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“…In CD, the median Pearson r correlation between the CD Endoscopic Index of Severity (CDEIS) and FC was 0.49, and for lactoferrin was 0.77 [27][28][29] ; the correlation with the simple endoscopic score for CD was similar for both FC (0.53) and lactoferrin (0.62) [27,30] . A meta-analysis with 550 patients evaluated the accuracy of CRP, FC and endoscopic scores, and it showed that in symptomatic patients (CDAI > 220), the sensitivity and specificity of CRP ≤ 5 mg/L or FC ≤ 200 μg/g to anticipate a CDEIS ≤ 6 was 83% and 71%, respectively [31] .…”

Section: The Role Of Faecal Calprotectin In the Monitoring Of Ibdmentioning

confidence: 88%