Serum Carcinoembryonic Antigen Level Predicts Cancer-Specific Outcomes of Resected Non-Small Cell Lung Cancer With Interstitial Pneumonia

Abstract

BackgroundIt has been well accepted that the prognosis of non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP) is significantly poor. However, there are only a few studies that indicated the prognostic factors, especially tumor markers, among NSCLC patients with IP.MethodsForty-one NSCLC patients with IP who underwent surgery at our institution were included. Patients died of other diseases including postoperative acute exacerbation (AE) of IP were excluded. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model.ResultsThe 5-year cancer-specific survival of overall and stage I patients were 37.4% and 39.2%, respectively. The 5-year cancer-specific survival of patients with high serum carcinoembryonic antigen (CEA) level was 9.4%, while that with normal serum CEA level was 55.6%. However, serum cytokeratin-19 fragment (CYFRA 21-1) and squamous cell carcinoma-related antigen (SCC) levels were not associated with patients’ survival. Furthermore, serum CEA level was significantly associated with poorer cancer-specific survival in univariate and multivariate analyses.ConclusionsThis study demonstrated that serum CEA level might serve as an efficient prognostic indicator after surgery in NSCLC with IP.

Combined assay of Circulating Tumor DNA and Protein Biomarkers for early noninvasive detection and prognosis of Non-Small Cell Lung Cancer

“…The level of protein biomarkers' specificity mainly depends on the cutoff value. In the current study, we established the cutoff values for CEA, CYFRA21-1, and SCC at 7.3 ng/mL, 4 ng/mL, and 2.5 ng/mL, respectively, based on previous reports 3 , 21 - 24 . These values are all above the clinical standard cutoff level (5 ng/mL, 3.3 ng/mL, and 1.5 ng/mL, respectively).…”

Evaluation of prognostic inflammatory and systemic inflammatory response indices in auxiliary diagnosis of bacteria-negative pulmonary tuberculosis: A diagnostic accuracy study

“…[ 20 , 21 ] PII and SIRI, which are derived by simple calculation from LY, NE, MO, CRP, and ALB, can reflect both the immune and systemic nutritional status of patients. [ 6 , 10 ] To the best of our knowledge, there are no domestic or international relevant studies on the auxiliary diagnostic value of PII and SIRI for pulmonary TB. The results of this study showed that LY, ALB, and PA were significantly lower in the case group as compared to the control group ( P < .05); while NE, MO, CRP, FIB, ESR, NLR, PII, and SIRI were significantly higher in the case group ( P < .05).…”

“…[6–9] PII and SIRI are calculated according to the laboratory indicators of patients during hospitalization, which has the added advantages of simplicity and convenience. [6,10] Pathological changes in pulmonary TB mainly include inflammatory exudation, hyperplasia, and caseous necrosis. [11] To the best of our knowledge, no study has utilized the efficacy of PII and SIRI in the diagnosis of bacteria-negative pulmonary TB.…”