Serum chemerin and vaspin in non-alcoholic fatty liver disease

Abstract

This study shows for the first time that chemerin and vaspin serum concentrations are altered in patients with NAFLD. The analyzed adipokines appear to play a pivotal role in the pathogenesis of NAFLD, not only as regulators of insulin sensitivity, but also as mediators of the inflammatory process.

Serum vaspin may be a good indicator of fibrosis in chronic hepatitis C and is not altered by antiviral therapy

“…Similar results were obtained by our group in NAFLD patients [22]. Up-regulation of vaspin in patients with marked fibrosis could be a compensatory mechanism having a protective effect directed against further liver injury and fibrosis progression.…”

“…Similarly, vaspin levels were up-regulated in non-alcoholic steatohepatitis as compared to simple steatosis and paralleled disturbances in HOMA-IR [22]. Since recently CHC has been recognized not only as viral but also as a metabolic disease similar to NAFLD, an interesting finding of our study was a positive relationship between the vaspin level and grade of steatosis in CHC patients.…”

“…The studies on NAFLD showed raised serum vaspin levels regardless of potential confounders [22,24]. Similarly, vaspin levels were up-regulated in non-alcoholic steatohepatitis as compared to simple steatosis and paralleled disturbances in HOMA-IR [22].…”

Vaspin mRNA levels in the liver of morbidly obese women with nonalcoholic fatty liver disease

“…After stepwise linear regression analysis, serum vaspin concentration was the only independent predictor of liver fibrosis in patients with NAFLD. Serum vaspin levels were up-regulated in NAFLD patients regardless of potentialconfounders [27].Ourpreviousstudyandthe studybyGencet aldidnotfindanyrelationshipbetweenserumvaspinandfibrosisstageinnon-severely obeseNAFLDpatients [25,26].However,ourstudy in CHC patients showed vaspin serum levels to be significantly higher in patients with significant and advanced fibrosis. Nonetheless, in patients without fibrosis and with insignificant fibrosis vaspin serum levels were significantly lower.…”

Chemerin in Non-Alcoholic Fatty Liver Disease ? Up or Down?

“…In humans liver chemerin mRNA positively correlates with NAFLD activity score, and is induced in patients with NASH [9,28]. Serum chemerin is found increased and unchanged in human NASH, and elevated levels are partly associated with higher BMI of the NAFLD patients [9,[28][29][30].…”