Serum cholesterol and impulsivity in a large sample of healthy young men

Pozzi, F.; Troisi, Alfonso; Cerilli, Marco; Autore, Alberto; Castro, C. Lo; Ribatti, Doménico; Frajese, Gaetano

doi:10.1016/s0165-1781(03)00192-6

Cited by 38 publications

(32 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yet, the regression model showed that low levels of omega-3 and omega-6 fatty acids were significantly associated with greater impulsivity scores. Different results emerged from another study also using multivariate analysis but based on a much larger sample (N = 2051) of young healthy men (Pozzi et al, 2003). These authors found that the subjects with low serum cholesterol, defined as the lowest tenth of the TC distribution (<150 mg/dl) showed greater impulsivity, as indicated by their significantly lower scores on the BFQ-IC scale.…”

Section: Impulsivitymentioning

confidence: 80%

“…The finding that psychiatric symptoms and behavioral disorders are associated more with naturally low cholesterol (Lester, 2002;Pozzi et al, 2003;Zhang et al, 2005) than with therapeutically lowered cholesterol (Gould et al, 2007;Muldoon et al, 2001;Wardle et al, 2000) points to this direction. Causing naturally low levels of cholesterol, polymorphisms of genes involved in the cholesterol biosynthesis or transport could contribute in opposite ways to cardiovascular and psychiatric vulnerability.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

Troisi

2009

Neuroscience & Biobehavioral Reviews

Self Cite

View full text Add to dashboard Cite

Section: Impulsivitymentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

Troisi

2009

Neuroscience & Biobehavioral Reviews

Self Cite

View full text Add to dashboard Cite

“…Tripodianakis et al [40] provided further confirmation to this hypothesis and found lower serum cholesterol in violent suicide attempters together with an increased noradrenaline turnover in such subjects. Further observations about relationships between impulsivity and violent behaviour seem to bring other indirect evidence to the connection between lower cholesterol levels and violent suicide attempts [41, 42]. …”

Section: Studies That Found An Association Between Cholesterol Andmentioning

confidence: 99%

The Relationships between Cholesterol and Suicide: An Update

Berardis

Marini

Piersanti³

et al. 2012

ISRN Psychiatry

View full text Add to dashboard Cite

Cholesterol is a core component of the central nervous system, essential for the cell membrane stability and the correct functioning of neurotransmission. It has been observed that cholesterol may be somewhat associated with suicidal behaviours. Therefore, the aim of this paper was to elucidate current facts and views about the role of cholesterol levels in mood disorders. The majority of the studies reviewed in the present paper suggest an interesting relationship between cholesterol (especially lower levels) and suicidality. On the other hand, particularly during the last years, relationships between serum cholesterol and suicidality were doubted on the basis of some recent studies that have not found any correlation. However, the debate on relationships between cholesterol and suicide is open and longitudinal studies on a larger sample of patients are needed to further clarify this important issue.

show abstract

“…Coutu et al [5] found that low levels of both total and low-density lipoprotein (LDL) cholesterol were associated with decreased anxiety. The most consistent association has been found between low cholesterol levels and impulsivity [6] , which is closely related to Cloninger's [7] temperament dimension of novelty seeking (NS). NS is proposed to be associated with variations in dopamine levels and refers to increased exploratory activity and intense excitement in response to novelty, impulsive decision-making, quick loss of temper, and active avoidance of monotony or frustration [8] .…”

Section: Introductionmentioning

confidence: 95%

Relationship between DRD4 Polymorphism and Lipid Metabolism: What Is the Role of Novelty Seeking?

Elovainio

Puttonen²,

Heponiemi³

et al. 2005

Neuropsychobiology

View full text Add to dashboard Cite

Objective: This study examined the association of the dopamine receptor D₄ (DRD4) gene polymorphism with the temperament dimension of novelty seeking (NS) on cardiovascular heart disease risk factors [the levels of high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides]. Method: From the ongoing population-based study of ‘Cardiovascular Risk in Young Finns’, 125 participants were DRD4 genotyped in 1997 and responded to the NS scale of the Temperament and Character Inventory in 2001. Their cholesterol and triglyceride concentrations were assessed in 2001. Results: Having a 2- or 5-allele DRD4 polymorphism was related to high HDL cholesterol levels in men, but to low HDL cholesterol levels in women. NS was related to triglycerides in men and to LDL in women, but this was mediated by behavioral, age, and weight factors, and NS was not the underlying factor for the association between the polymorphism and lipids. Conclusion: Our preliminary findings suggest that there is a link between the dopaminergic receptor gene DRD4 and lipid metabolism, but this link is dependent on gender.

show abstract

Serum cholesterol and impulsivity in a large sample of healthy young men

Cited by 38 publications

References 30 publications

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

The Relationships between Cholesterol and Suicide: An Update

Relationship between DRD4 Polymorphism and Lipid Metabolism: What Is the Role of Novelty Seeking?

Contact Info

Product

Resources

About