Serum cholesterol levels and postoperative atrial fibrillation

Abstract

BackgroundPost-operative atrial fibrillation is an important complication after coronary bypass surgery. As inflammation and oxidative stress were makedly encountered in the etiology, high cholesterol was also defined to provoke atrial fibrillation. In this present study, the relationship between postoperative atrial fibrillation and preoperative serum lipid levels were evaluated.MethodsA total of 100 patients, who were operated at the department of Cardiovascular Surgery of our hospital were included to the study analysis. Patients, who had preoperative atrial fibrillation, thyroid dysfunction, or left atrial dilatation (above 4.5 cm) were excluded from the study. Patients were divided into two groups with postoperative atrial fibrillation development (Group I n = 36), and without atrial fibrillation development (Group II n = 64). Preoperative routine blood analyses, ECG, echocardiography were evaluated. Patients were followed for atrial fibrillation development for one month starting from the intensive care unit at the postoperative period. Serum lipid profiles and thyroid function were measured. For homogenization of inflammatory factors and oxidative stress, treatments other than statins, betablockers, calcium channel blockers, aspirin, ACE inhibitors, and ARB were stopped for 10 days. Atrial fibrillation for at least ≥5 minutes in the intensive care unit was accepted as postoperative atrial fibrillation.ResultsDemographic data were similiar between groups (p > 0.05). There was no difference in TC levels between groups, whereas LDL-C levels were statistically lower in patients developing post-operative atrial fibrillation (106.67 ± 28.36 vs 118.75 ± 27.75; P < 0.05).ConclusionThe more lowered is the LDL-C in the preoperative period, the more reduced risk of postoperative atrial fibrillation development. High levels of LDL-C in the preoperative period could be predictor of atrial fibrillation development in the post operative period.

Association of clinical predictors with recurrence of atrial fibrillation after catheter ablation

“…Still, we showed that high LDL‐C levels were positively correlated with an increased risk of AF recurrence in patients undergoing RFCA. The result was consistent with a previous study investigating serum lipid levels with AF recurrence (Aydin et al, 2014). It suggested that the lower serum LDL‐C level in the preoperative period was associated with reduced risk of AF recurrence.…”

“…Those ion channel characteristics would influence Ca 2 accumulation in the cellular membrane, which is associated with AF initiation (Bastiaanse, Hold, & Van der Laarse, 1997; Saini, Arneja, & Dhalla, 2004). Decrease in LDL‐C levels by apheresis in patients with high serum LDL‐C levels has been shown to have a protective effect against the development of AF (Aydin et al, 2014). However, whether lipid‐lowering treatment reduces the risk of AF depends on different situations.…”

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

“…Additionally, those patients tend A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 7 to have increased atrial conduit function, and evidence of left ventricular diastolic relaxation impairment compared to those without AF (Aytemir, Aksoyek, Ozer, Aslamaci, & Oto, 1999;Ferro, et al, 2009;Leung, Bellows, & Schiller, 2004;Maesen, et al, 2012;Nakai, et al, 2002;Nardi, et al, 2012). Other abnormalities that have been associated with increased incidence of POAF include high pre-operative levels of cholesterol (Aydin, et al, 2014).…”

Dyslipidemia in patients with atrial fibrillation on the background of acute coronary syndrome according to the register of the Krasnodar region

“…Предполагается, что антиаритмический эффект проявляется посредством внутриклеточного гомеостаза кальция различными структурами статинов на разных уровнях, поскольку внутриклеточный мевалонатзависимый синтез холестерина ингибируется статинами. Низкий уровень холестерина в сыворотке замедляет внутриклеточное потребление ЛПНП, что обеспечивает стабильность клеточной мембраны и ингибирует электрическое ремоделирование, воздействуя на внутриклеточные уровни Ca [25].…”