Serum Cholinesterase Level as a Biomarker in Detecting Liver Injury in Patients with Chronic Hepatitis C

Salama, Salem Soliman Ahmed; El-Bahnasawy, Bahy El-Deen El-Sayed; Hashish, Mahmoud Abd El-Latif; Ebiary, Mustafa Mohammed Mustafa Al

doi:10.21608/ejhm.2019.45659

Cited by 2 publications

(1 citation statement)

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“…Hassan et al found that all patients with chronic liver diseases had a significantly lower level of serum cholinesterase than the control group, and they concluded that serum cholinesterase is a preferred diagnostic and prognostic biomarker over traditional liver function tests, which are elevated in other diseases (17). Salama et al's study showed that the sensitivity of serum cholinesterase, its specificity, and its accuracy are all 100% in predicting liver damage in individuals with chronic hepatitis C (18). Roshankumar Jha and Mahajan found that the cholinesterase levels are closely related to the severity of liver cell damage (19).…”

Section: Discussionmentioning

confidence: 99%

Study of serum cholinesterase as a biomarker in a sample of patients with viral hepatitis B or hepatitis C in Baghdad

Rasheed¹,

Hassan²,

Jassim

2022

ijhs

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The most prevalent illnesses that affect the liver are viral infections; when the liver cell is destroyed by viruses, it loses its function and most of the body's processes are compromised. The liver is the primary source of serum cholinesterase. Therefore, serum cholinesterase can be used as a predictive biomarker for the liver's synthetic capability. This study aims to evaluate serum cholinesterase as a biomarker in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV). The study was conducted at the Gastroenterology and Hepatology Teaching Hospital and Poisoning Consultation Center in Baghdad during the interval from November 2021 to March 2022. The liver function tests and serum cholinesterase were measured in one hundred fifty samples. Fifty patients with HBV and fifty patients with HCV were compared with fifty healthy individuals as a control group. The mean serum cholinesterase in the HBV and HCV patient groups (8528.76±2000.45 U/L and 7494.12± 2586.30 U/L, respectively) was lower than in the control group (9380.12±1848.96 U/L), and the difference was statistically significant (P < 0.05). The mean serum cholinesterase in the HCV patient group (7494.12±2586.30 U/L) was significantly lower (P < 0.05) than in the HBV patient group (8528.76 ±2000.45 U/L).

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Section: Discussionmentioning

confidence: 99%