Serum chromogranin A correlated with albuminuria in diabetic patients and is associated with early diabetic nephropathy

Abstract

Background The kidney is the main site for the removal of chromogranin A (CgA). Previous studies have found that patients with renal impairment displayed elevated concentrations of CgA in plasma and that CgA concentrations reflect a deterioration of renal function. In this study, we aimed to estimate serum CgA levels and to evaluate the role of serum CgA in the early diagnosis of diabetic nephropathy (DN). Methods A total of 219 patients with type 2 diabetes mellitus (T2DM) were included in this cross-sectional study. These patients were classified into normoalbuminuria (n = 121), microalbuminuria (n = 73), or macroalbuminuria (n = 25) groups based on their urine albumin to creatinine ratios (UACRs). The degree of DN is reflected by UACR. A control group consisted of 45 healthy subjects. The serum CgA levels were measured by ELISA, and other key parameters were assayed. Results Serum CgA levels were higher in patients with T2DM than in control subjects, and a statistically significant difference among the studied subgroups regarding CgA was found (P < 0.05). The levels of serum CgA increased gradually with the degree of DN (P < 0.001). Serum CgA levels showed a moderate-intensity positive correlation with UACRs (P < 0.001). A cutoff level of 3.46 ng/ml CgA showed 69.86% sensitivity and 66.12% specificity to detect DN in the early stage. Conclusion The levels of serum CgA increased gradually with the degree of DN and can be used as a biomarker in the early detection of DN.

Correlation of Serum Chromogranin A with HbA1c and eGFR in Different Groups of Type 2 Diabetic patients

“…A cutoff level of 3.46 ng/ml CgA showed 69.86% sensitivity and 66.12% specificity to detect DN in the early stage. 17 Their results were in line with our findings that showed higher serum CgA levels with deteriorating renal functions. Limitations of study: Financial constrains, small sample size and limited resources with no genetic workup added to our limitations.…”

Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs

“…In previous studies, the plant extract showed restorative properties of ALT, ALP, total bilirubin and AST [ 30 ]. As a result of diabetes, a raise in serum creatinine and urea was seen, which were considered major indicators of renal impairment [ 31 ]. A result from anti-diabetic research of Carduus acicularis and Cirsium maackii was consistent with our results [ 32 ].…”

MicroRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes mellitus and its complications: A narrative review

“…It is also anticipated that up to 700 million people worldwide could have DR by 2045 15 . Thus, researchers have attempted to establish novel diagnostic and prognostic parameters for predicting the onset of DM and its complications in the early phase 16,17 …”

“…15 Thus, researchers have attempted to establish novel diagnostic and prognostic parameters for predicting the onset of DM and its complications in the early phase. 16,17 Different metabolic organs communicate through the neuronal and hormonal media in different physiologic and pathologic conditions. 18 Among these, adipose-immune-pancreatic cell crosstalk is an essential pathway in the pathogenesis of diabetes and other metabolic disorders.…”