Serum Circulating Free Dna of Syncytin-1 As A Novel Molecular Marker for Early Diagnosis of Non-Small-Cell Lung Cancer

Zhuang, Xianghua; Qian, Jingrong; Xia, Xiyan; Wang, Yuanling; Wang, Hongchun; Jing, Liping; Zhang, Yong

doi:10.2217/bmm-2022-0499

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…In non-small cell lung cancer (NSCLC), the syncytin-1 gene is increased expression due to chromosome activation and nucleosome depolymerization. Thus, the circulating free DNA of syncytin-1 is increased in the serum of NSCLC patients [ 124 ]. And the expression of syncytin-1 was significantly higher in NSCLC tissues than in para-carcinoma tissues.…”

Section: Syncytin-1 and Tumorsmentioning

confidence: 99%

Molecular mechanisms of syncytin-1 in tumors and placental development related diseases

Wang,

Shi,

Bian

et al. 2023

Discov Onc

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Human endogenous retroviruses (HERVs) have evolved from exogenous retroviruses and account for approximately 8% of the human genome. A growing number of findings suggest that the abnormal expression of HERV genes is associated with schizophrenia, multiple sclerosis, endometriosis, breast cancer, bladder cancer and other diseases. HERV-W env (syncytin-1) is a membrane glycoprotein which plays an important role in placental development. It includes embryo implantation, fusion of syncytiotrophoblasts and of fertilized eggs, and immune response. The abnormal expression of syncytin-1 is related to placental development-related diseases such as preeclampsia, infertility, and intrauterine growth restriction, as well as tumors such as neuroblastoma, endometrial cancer, and endometriosis. This review mainly focused on the molecular interactions of syncytin-1 in placental development-related diseases and tumors, to explore whether syncytin-1 can be an emerging biological marker and potential therapeutic target.

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Section: Syncytin-1 and Tumorsmentioning

confidence: 99%

Molecular mechanisms of syncytin-1 in tumors and placental development related diseases

Wang,

Shi,

Bian

et al. 2023

Discov Onc

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Impact of periodontitis on circulating cell-free DNA levels as a measure of cardiovascular disease

Isola,

Polizzi,

Mascitti

et al. 2023

Clin Oral Invest

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Objectives The present study aims to assess the serum circulating cell-free (cfDNA) concentrations in patients with periodontitis and cardiovascular disease (CVD) and to evaluate the impact of periodontitis on circulating cfDNA levels and the confounding factors that might mediated the possible relationship. Materials and methods Healthy controls (n=30) and patients with CVD (n=31), periodontitis (n=31), and periodontitis + CVD (n=30) were enrolled in the present study. All subjects underwent regular periodontal examination and blood sampling and cfDNA evaluation. The analysis of the plasma cfDNA concentrations was performed using a dsDNA Assay Kit. Results In comparison with healthy controls and CVD patients, periodontitis and periodontitis+CVD exhibited significantly higher expression of circulating cfDNA (p<0.05). There was a positive correlation among plasma cfDNA and clinical attachment loss (CAL) (p=0.019), high sensitivity C-reactive protein (hs-CRP) (p=0.027), and periodontal inflamed surface area (PISA) (p=0.003). Furthermore, the multivariate regression analysis evidenced that PISA (p<0.001), hs-CRP (p=0.014), and full-mouth bleeding score (FMBS) (p=0.004) were significant predictors of circulating cfDNA concentrations. Conclusions The results of the study highlighted that the periodontitis and periodontitis + CVD group showed higher circulating cfDNA expression in comparison with healthy controls and CVD patients. Moreover, the extent of periodontitis was correlated with the increased cfDNA levels and represented a significant predictor of the increased circulating cfDNA concentrations. Clinical relevance Unbalanced circulating cfDNA concentrations have been indicated to represent a possible risk of CVD and endothelial dysfunction. Periodontitis and periodontitis + CVD patients showed higher circulating cfDNA expression; moreover, the extent of periodontitis significantly predicted higher circulating cfDNA concentrations, suggesting the potential increased risk of developing CVD in periodontitis patients.

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Serum Circulating Free Dna of Syncytin-1 As A Novel Molecular Marker for Early Diagnosis of Non-Small-Cell Lung Cancer

Cited by 2 publications

References 29 publications

Molecular mechanisms of syncytin-1 in tumors and placental development related diseases

Molecular mechanisms of syncytin-1 in tumors and placental development related diseases

Impact of periodontitis on circulating cell-free DNA levels as a measure of cardiovascular disease

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