Serum Coenzyme Q10 in Uremic Patients on Chronic Hemodialysis

Abstract

In a group of 48 chronic hemodialysis patients, serum levels of coenzyme Q10 (CoQ) have been measured and appeared abnormally low in 62% of cases. Figures were positively correlated to those of serum vitamin E (vit E), although the latter were within a normal range. The chronic hemodialysis (CHD) patients with normal serum values of CoQ exhibited higher blood triglycerides. Pathologically low levels of serum vit E were found only in uremic subjects on conservative regimen with dietary restrictions and low compliance to protein-caloric intake. The reduced CoQ levels may contribute to the defective serum antioxidant activity and the increased peroxidative damage in uremic patients on CHD.

Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect on the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker

“…Because of this, the administration of vitamin C may indirectly enhance the antioxidant actions of physiologically existing vitamin E to lower the increased plasma Cu/Zn-SOD. The vitamin E plasma levels in hemodialysis patients, however, are reported to be low [28], and because of this, vitamin C administration could not demonstrate a synergistic antioxidant effect. It would be informative if the effects on Cu/Zn-SOD were examined with combined administration of vitamin C and vitamin E.…”

“…Vitamin C is reported to work as an antioxidant not only in plasma but also in the cytosol [4, 28]. The reduced form of vitamin C (ascorbate) is incorporated into leukocytes via a sodium-dependent ascorbate transporter, and the oxidized form of vitamin C (dehydroascorbic acid) via glucose transporters [30].…”

Cancer in End-Stage Renal Disease: Potential Factors Involved

“…As the cancer-preventive effect of a diet rich in fruits and vegetables has been clearly and consistently demonstrated by many epidemiological studies, the low consumption of these dietary components in MHD patients may also be a factor for their increased cancer risk [39][40][41][42].…”

Plasma mevalonate and its importance in nephrology

“…Measurement of circulating MVA and other non-sterol isoprenoid products [28,34], as well as the study of the factor (s) influencing their metabolism in renal human pathology may help to improve our understanding of the pathogenesis of lipid abnormalities in renal diseases. In addition, further studies may also improve our understanding of the intracellular MVA pathway which appears to be critical for the growth and proliferation of renal mesangial cells.…”