Serum complement and immunoglobulin values in small-for-gestational-age infants

Shapiro, Ralph; Beatty, David M.; Woods, David; Malan, Arnaud G.; MEd, Miller

doi:10.1016/s0022-3476(81)80979-1

Cited by 38 publications

(23 citation statements)

References 8 publications

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“…Previous studies have reported a significative correlation of complement activity with birth weight (1, 13, 15) but this was probably due to the effect of gestational age on birth weight. In fact Shapiro et al (15) found no differences between AGA and SGA term infants of different birth weights but comparable gestational ages. Indeed our results also show that in infants of comparable birth weights, complement activity is significantly influenced by differences in gestational age.…”

Section: Discussionmentioning

confidence: 92%

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

et al. 1984

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SummaryComplement activity was compared in 50 low birth weight infants divided into appropriate and small for gestational age groups; the influence of birth weight and gestational age on complement development was also investigated. CHW and kinetics (tHso) of both classical and alternative pathway activity of complement, C3, and Factor B levels were significantly higher in small for gestational age infants (classical pathway CHs, 630 HU/ml f 184 SD, C P tHs, 77 min + 47; aternative pathway CHS0, 44.8 HU/ml & 11.3; AP tHso, 56 min f 43; C3, 73.98 mg/dl f 12.68; and Factor B, 13.17 mg/dl 2 3.67) than in weight-matched appropriate for gestational age infants (CP CHW, 523 HU/ml 2 152; C P tH9, 105 min + 49; AP CHW, 38.8 HU/ml f 13; AP tHW, 90 min 2 53; C3, 58.14 mg/dl f 9.43; and Factor B, 9.32 mg/dl+ 1.73). Complement values were lower in low birth weight infants than in adult controls ( P < 0.001 in all cases). All complement parameters were mainly correlated with gestational age; CHso values of the classical and alternative pathways were also highly correlated with each other

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Section: Discussionmentioning

confidence: 92%

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

et al. 1984

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“…Hemolytic titers of both the classical and alternative pathways are lower in cord than in adult serum [22][23][24][25]. This is in part the result of subnormal concentrations of the proteins of the amplification loop.…”

Section: The Complement Profile In Early Lifementioning

confidence: 99%

“…This is in part the result of subnormal concentrations of the proteins of the amplification loop. In cord blood, levels of C3 [22-24, 26, 27] and factor B [22,23,26] are low. Factors I and H are also reduced [26].…”

Section: The Complement Profile In Early Lifementioning

confidence: 99%

The Complement Profile in Clinical Medicine

West¹

1989

Complement Inflamm

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The serum complement profile of patients with systemic or discoid lupus erythematosus, synovitis, vasculitides, certain recurrent or chronic skin rashes, recurrent or fulminant infections, particularly with Neisseria, may reveal homozygous deficiencies of complement components causally related to the illness. The nephritis of systemic lupus erythematosus (SLE) is often accompanied by a distinctive complement profile which indicates classical pathway activation and which can be used as an index of the success of treatment. In membranoproliferative glomerulonephritis (MPGN), the hypocomplemen- temia may reflect classical pathway activation in type I, the nephritic factor of the amplification loop in type II, or a nephritic factor activating terminal components in type III. In acute poststreptococcal glomerulonephritis, the cause of the hypocomplementemia is not known but the profile usually differs from that of MPGN or SLE. In these acquired hypo- complementemias, the profile supplements the renal biopsy in providing diagnostic information.

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“…Nevertheless, serum immunoglobulin concentrations remain very low (below 100 mg/dL) until 18-20 weeks of gestation. Small for gestational age (SGA) neonates may have somewhat lower IgG levels than full-term neonates, reflecting possible impaired placental transport (Shapiro et al 1981;Einhorn et al 1987). …”

mentioning

confidence: 99%

Transient hypogammaglobulinemia of infancy

OvadiaAdi

DalalIlan

2014

LymphoSign Journal

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Transient hypogammaglobulinemia of infancy (THI) was first described as a distinct entity by Gitlin and Janeway in 1956. Although THI has been recognized for many years, and despite significant progress in understanding the molecular basis and identifying the genes involved in the pathogenesis of many other forms of humoral immunodeficiencies, not much is known about this specific entity. This article summarizes the definition of THI, possible etiologies, clinical manifestations, treatment, and prognosis.

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Serum complement and immunoglobulin values in small-for-gestational-age infants

Cited by 38 publications

References 8 publications

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

The Complement Profile in Clinical Medicine

Transient hypogammaglobulinemia of infancy

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