Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Bugdaci, Mehmet Sait; Karaca, Çetin; Alkım, Canan; Kesici, Beşir; Bayraktar, Banu; Sokmen, Mehmet

doi:10.4318/tjg.2012.0310

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…According to the proteomic analysis of patients with chronic hepatitis C virus infection, some researchers revealed that complement C4a could be a candidate to predict liver fibrosis . Other researchers also found that serum complement C4 level was significantly correlated with histological activity in CHC patients . Though a few studies focused on the influence of complement C4a on HBV infection patients at present, those scholars paid attention to C4 gene and identified that C4 gene deletions were associated with nonresponse of the virus to hepatitis B vaccine .…”

Section: Discussionmentioning

confidence: 99%

Complement C4a inhibits the secretion of hepatitis B virus screened by surface‐enhanced laser desorption ionization time‐flight mass spectrometry‐based ProteinChip analysis

Song

Zhang

et al. 2015

Proteomics Clinical Apps

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Section: Discussionmentioning

confidence: 99%

Complement C4a inhibits the secretion of hepatitis B virus screened by surface‐enhanced laser desorption ionization time‐flight mass spectrometry‐based ProteinChip analysis

Song

Zhang

et al. 2015

Proteomics Clinical Apps

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“…In addition, a cross-sectional study suggested that plasma C3 levels are associated with liver fat and paralleled the degree of liver injury (Wlazlo et al 2013). Compared with those with normal transaminase levels, serum C3 and C4 levels in patients with high transaminase levels were significantly lower (Bugdaci et al 2012). Moreover, we previously found that C3 and C4 were associated with the risk of MetS (Liu et al 2016), which is one of the risk factors of NAFLD.…”

Section: Introductionmentioning

confidence: 90%

Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis

Huang

Yang

et al. 2021

Phenomics

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The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship between serum C3 and C4 levels and NAFLD. After exclusion criteria, a total of 1600 Chinese Han men from the Fangchenggang Area Male Health and Examination Survey cohort were enrolled in cross-sectional analysis, while 572 participants were included in the longitudinal analysis (average follow-up of 4 years). We performed a bidirectional Mendelian randomization (MR) analysis using two C3-related, eight C4-related and three NAFLD-related gene loci as instrumental variables to evaluate the causal associations between C3, C4, and NAFLD risk in cross-sectional analysis. Per SD increase in C3 levels was significantly associated with higher risk of NAFLD (OR = 1.65, 95% CI 1.40, 1.94) in cross-sectional analysis while C4 was not (OR = 1.04, 95% CI 0.89, 1.21). Longitudinal analysis produced similar results (HR C3 = 1.20, 95% CI 1.02, 1.42; HR C4 = 1.10, 95% CI 0.94, 1.28). In MR analysis, there were no causal relationships for genetically determined C3 levels and NAFLD risk using unweighted or weighted GRS_C3 (β E_unweighted = −0.019, 95% CI −0.019, −0.019, p = 0.202; β E_weighted = −0.019, 95% CI −0.019, −0.019, p = 0.322). Conversely, serum C3 levels were significantly effected by the genetically determined NAFLD (β E_unweighted = 0.020, 95% CI 0.020, 0.020, p = 0.004; β E_weighted = 0.021, 95% CI 0.020, 0.021, p = 0.004). Neither the direction from C4 to NAFLD nor the one from NAFLD to C4 showed significant association. Our results support that the change in serum C3 levels but not C4 levels might be caused by NAFLD in Chinese Han men.

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“…In this study, we determined significant AUC values between noninvasive tests in the literature regarding patients with hepatitis C. However, why different AUC values are obtained in patients with CHB and in patients with CHC despite the similarities in grades and stages is a matter of debate. Although patients with hepatitis B and C present with similar histopathological findings and are evaluated with the same scoring system, the observation of marked hepatosteatosis in patients with CHC (22) and the presence of inflammatory destruction and complementary activity suggest to us that different ultrastructural mechanisms may play a role (5,25).…”

Section: Discussionmentioning

confidence: 99%

Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C

Bugdaci

Korkmaz²,

Demir³

et al. 2014

Turk J Gastroenterol

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Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45±13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52±10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be ≥1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI:0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be ≥1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC:0.95, 95% CI:0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.

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Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Abstract: Amaç: Hepatit C virüsü kronik karaci¤er hastal›¤›, siroz ve hepatosellüler kansere neden olmaktad›r. Kronik hepatit C'nin tan› ve takibinde kullan›lan viral marker ve laboratuvar testleri hastal›¤›n aktivitesi ve karaci¤er histopatolojik bulgular›yla iyi korelas

Cited by 7 publications

References 27 publications

Complement C4a inhibits the secretion of hepatitis B virus screened by surface‐enhanced laser desorption ionization time‐flight mass spectrometry‐based ProteinChip analysis

Complement C4a inhibits the secretion of hepatitis B virus screened by surface‐enhanced laser desorption ionization time‐flight mass spectrometry‐based ProteinChip analysis

Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis

Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C

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