Serum concentration of bisphenol analogues in pregnant women in China

Li, Aijing; Zhuang, Taifeng; Shi, Wei; Liang, Yong; Liao, Chunyang; Song, Meirong; Jiang, Guibin

doi:10.1016/j.scitotenv.2019.136100

Cited by 152 publications

(64 citation statements)

References 41 publications

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“…The EC 50 -values estimated from these curves ranged from 0.79 to 14.87 µM and the lowest effective dose values (EC 05 ) ranged from 0.18 to 2.37 µM ( Table 2). In the literature, we could only identify human plasma or serum levels for BPAF, BADGE, and BPB out of the six "positive hit" bisphenols (49)(50)(51)(52)(53). A reported maximal human serum concentration of BADGE (3.45 µM) (50) is above the EC 05 estimated in our study (1.82 µM), whereas the reported maximal human serum levels of BPAF (0.05 µM) (50) and BPB (0.59 µM) (50) are below the estimated EC 05 -values of 0.36 µM for BPAF and 2.37 µM for BPB.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

2020

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Aim: Evidence suggests that bisphenol A diglycidyl ether (BADGE), bisphenol A (BPA), and BPA analogs can interfere with human male fertility. However, the effect directly on human sperm function is not known. The CatSper Ca 2+ channel in human sperm controls important sperm functions and is necessary for normal male fertility. Environmental chemicals have been shown to activate CatSper and thereby affect Ca 2+ signaling in human sperm. BPA has previously been investigated for effects on Ca 2+ signaling human sperm, whereas the effects of other BPA analogs are currently unknown. The aim of this study is thus to characterize the effect of BADGE, BPA, and the eight analogs BPG, BPAF, BPC, BPB, BPBP, BPE, BPF, BPS on Ca 2+ signaling, and CatSper in human sperm. Methods: Direct effects of the bisphenols on Ca 2+ signaling in human sperm cells were evaluated using a Ca 2+ fluorimetric assay measuring changes in intracellular Ca 2+. Effects via CatSper were assessed using the specific CatSper inhibitor RU1968. Effects on human sperm function was assessed using an image cytometry-based acrosome reaction assay and the modified Kremer's sperm-mucus penetration assay. Results: At 10 µM the bisphenols BPG, BPAF, BPC, BADGE, BPB, and BPBP induced Ca 2+ signals in human sperm cells, whereas BPE, BPF, BPS, and BPA had no effect. The efficacy of the chemicals at 10 µM is BPG > BPAF > BPC > BADGE > BPB > BPBP. Dose-response relations of BPG, BPAF, BPC, BADGE, BPB, and BPBP yielded EC50-values in the nM-µM range. The induced Ca 2+ signals were almost completely abolished using the CatSper inhibitor RU1968, indicating an effect of the bisphenols on CatSper. All bisphenols, except BPBP, were found to dose-dependently inhibit progesterone-induced Ca 2+ signals, with BPG and BPAF displaying inhibition even in low µM doses. BPG and BPAF were shown to affect human sperm function in a progesterone-like manner. Rehfeld et al. Bisphenols Activate Human CatSper Conclusion: Our results show that the bisphenols BPG, BPAF, BPC, BADGE, BPB, and BPBP can affect Ca 2+ signaling in human sperm cells through activation of CatSper. This could potentially disrupt human sperm function by interfering with normal CatSpersignaling and thus be a contributing factor in human infertility, either alone or in mixtures with other chemicals.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

2020

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“…In some rivers, BPA concentration could even reach up to 8 μg/L (Huang et al 2012), and the report from Barboza et al also revealed the present of BPA and its analogs in muscle and liver of sh (Barboza et al 2020). In China, up to 144 ng/mL of bisphenol analogues was detected in serum samples from pregnant women (Li et al 2020) studied. Chemical oxidation is widely used for wastewater treatment, such as Fenton process (Chmayssem et al 2017) and ozone treatment (Akbari et al 2016) could effectively oxidize the organic contaminants in the aquatic system.…”

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 96%

Influence of Aqueous Chloride and Bromide Anions on the Reactivity of ZnO on Bisphenol a Degradation

Yang

Sahu

Shih

2021

Preprint

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Zinc oxide (ZnO) nanoparticles have been widely investigated for applications in photocatalytic degradation of organic pollutants in wastewater. Despite the advantages of robust ZnO material, its photocatalytic activity is greatly affected by environmental factors. Halogen ions are commonly found in wastewater, which directly influence the pollutant aggregation and sedimentation, therefore it is necessary to discuss their effect on the photodegradation. The current study assesses the halogen ions effect on the photocatalytic degradation of BPA using different dosage of sodium chloride (NaCl) and sodium bromide (NaBr). The microstructural characterization of ZnO was conducted by transmission electron microscopy and hydrodynamic size was analyzed through dynamic light scattering. Degradation reactions of BPA with ZnO nanoparticles followed pseudo-first-order kinetics. The increase of ZnO dosage from 0.01 g/L to 0.1 g/L enhanced the degradation rate constant of BPA up to 0.089 min-1 (14.8 folds). In order to evaluate the the role halogen ions to degrade BPA, NaBr and NaCl were used. The degradation rate was reduced up to 26 folds (0.0034 min-1) after the addition of NaBr, which was attributed to the increase in hydrodynamic particle size leading, thereby restricting the light adsorption capacity. Noteworthy, upon addition of NaCl from 10 mM to 500 mM concentration, there was only a slight decrease (2.4 folds, 0.037 min-1) on the degradation rate of BPA. Therefore, this study unveils the role of chloride ions as an effective medium for BPA degradation by ZnO nanoparticles, without aggregation, and provides a novel platform for the treatment of organic pollutants in saline water.

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“…In a survey for 190 women in Hangzhou, China, showed that, besides BPA (average level of 2.5 ng/mL), BPS (0.19 ng/mL) and BPAF (0.092 ng/mL) were also detectable in breast milk ( 150 ). In the serum samples of 181 Chinese pregnant women, BPS, BPF, BPAF, BPB, BPP, BPZ, BPAP, TBBPA, tetrabromobisphenol S (TBBPS), and tetrachlorobisphenol A (TCBPA) were detected, and TBBPS was 0.593 ng/mL and BPS was 0.113 ng/mL ( 151 ). BPB was detected in the urine of Portuguese volunteers, and its level was similar to BPA ( 152 ) ( Table 1 ).…”

Section: Bpa Analogsmentioning

confidence: 99%

Bisphenols and Leydig Cell Development and Function

Zhu²,

Wang

et al. 2020

Front. Endocrinol.

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Bisphenol A (BPA) is a ubiquitous environmental pollutant, mainly from the production and use of plastics and the degradation of wastes related to industrial plastics. Evidence from laboratory animal and human studies supports the view that BPA has an endocrine disrupting effect on Leydig cell development and function. To better understand the adverse effects of BPA, we reviewed its role and mechanism by analyzing rodent data in vivo and in vitro and human epidemiological evidence. BPA has estrogen and anti-androgen effects, thereby destroying the development and function of Leydig cells and causing related reproductive diseases such as testicular dysgenesis syndrome, delayed puberty, and subfertility/infertility. Due to the limitation of BPA production, the increased use of BPA analogs has also attracted attention to these new chemicals. They may share actions and mechanisms similar to or different from BPA.

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Serum concentration of bisphenol analogues in pregnant women in China

Cited by 152 publications

References 41 publications

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Influence of Aqueous Chloride and Bromide Anions on the Reactivity of ZnO on Bisphenol a Degradation

Bisphenols and Leydig Cell Development and Function

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Serum concentration of bisphenol analogues in pregnant women in China

Cited by 152 publications

References 41 publications

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Influence of Aqueous Chloride and Bromide Anions on the Reactivity of ZnO&nbsp;on Bisphenol a Degradation

Bisphenols and Leydig Cell Development and Function

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Influence of Aqueous Chloride and Bromide Anions on the Reactivity of ZnO on Bisphenol a Degradation