Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Mündermann, Annegret; Dyrby, Chris O.; Andriacchi, Thomas P.; King, Karen B.

doi:10.1016/j.joca.2004.09.007

Cited by 141 publications

(218 citation statements)

References 18 publications

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“…For instance, serum concentrations of cartilage oligomeric matrix protein (COMP) increase after exercise bouts of walking (Mündermann, Dyrby, Andriacchi, & King, 2005;Mündermann, King, Smith, & Andriacchi, 2009;Pruksakorn et al, 2013), running (Kersting, Stubendorff, Schmidt, & Bruggemann, 2005;Niehoff et al, 2010;Niehoff et al, 2011) and marathon running (Neidhart et al, 2000) but not after deep knee bends (Niehoff et al, 2010). Hence, load-induced changes in COMP appear to be sensitive to load magnitude.…”

Section: Introductionmentioning

confidence: 99%

Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Mündermann

Geurts

Hügle

et al. 2016

Journal of Sports Sciences

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Section: Introductionmentioning

confidence: 99%

Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Mündermann

Geurts

Hügle

et al. 2016

Journal of Sports Sciences

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“…The relationship between various degrees of load intensity in the physiological condition and the circulation pattern of biomarkers has also been addressed in order to determine the reliability of each biomarker. (1)(2)(3) This is an important step in the validation process of biomarkers, prior to their use in clinical application. Furthermore, the sensitive relationship between minor changes in cartilage structure and serum biomarkers could be used for optimising activities to prevent long-term unfavourable consequences due to subclinical damage.…”

Section: Introductionmentioning

confidence: 99%

Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk

Pruksakorn¹,

Tirankgura²,

Luevitoonvechkij³

et al. 2013

smedj

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RESUlTSBoth groups shared similar demographic characteristics and activity duration. At T2, the serum COMP level of the experimental group was significantly higher than that of the control group, but the serum HA level of the experimental group was significantly lower than that of the control group. No significant difference between the serum WF6 levels of the experimental and control groups was observed at T2. CONClUSIONIncreasing levels of serum COMP demonstrate articular cartilage susceptibility to the increasing load. An unsustainable, high serum COMP level and an undetectable change in WF6 level were considered to be a reversible physiological change of the cartilage. A change in serum HA level could be related to intensive physical activity and dynamic clearance rather than a change in cartilage structure.

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“…The fulcrum of the biomechanic factors is joint loading, which in fact is associated with the pathogenesis of medial knee OA (9,(11)(12)(13)(14)(15). The knee joint loading during walking is of particular interest because walking is the most common method of human locomotion and causes repetitive joint loading.…”

Section: Introductionmentioning

confidence: 99%

Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

Henriksen¹,

Graven‐Nielsen²,

Aaboe³

et al. 2010

Arthritis Care & Research

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Objective. Medial knee osteoarthritis (OA) is characterized by pain and associated with abnormal knee moments during walking. The relationship between knee OA pain and gait changes remains to be clarified, and a better understanding of this link could advance the treatment and prevention of disease progression. This study investigated changes in knee moments during walking following experimental knee pain in healthy volunteers, and whether these changes replicated the joint moments observed in medial knee OA patients. Methods. In a crossover study, 34 healthy subjects were tested on 3 different days; gait analyses were conducted before, during, and after pain induced by hypertonic saline injections (0.75 ml) into the infrapatellar fat pad. Isotonic saline and sham injections were used as control conditions. Peak moments in frontal and sagittal planes were analyzed. The results were compared with data from 161 medial knee OA patients. The patients were divided into less severe OA and severe OA categories, which was based on radiographic disease severity of the medial compartment. Results. Experimental knee pain led to reduced peak moments in the frontal and sagittal planes in the healthy subjects, which were similar to the patterns observed in less severe OA patients while walking at the same speed. Conclusion. In healthy subjects, pain was associated with reductions in knee joint moments during walking in a manner similar to less severe knee OA patients. The experimental model may be used to study mechanically-driven knee OA progression and preventive measures against abnormal joint loading in knee OA.

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Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults

Abstract: Even a moderate walking activity can significantly influence serum COMP concentration. The immediate response points to a diffusion time of COMP fragments from cartilage to the blood of 30 min or less. The response at 5.5h indicates a metabolic delay for COMP in the range of 5h to 6h.

Cited by 141 publications

References 18 publications

Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk

Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

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