Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease

Yagi, Shusuke; Hara, Tomoya; Ueno, Rie; Aihara, Ken‐ichi; Fukuda, Daiju; Takashima, Akira; Hotchi, Junko; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Igarashi, Takashi; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Shimabukuro, Michio; Akiyama, Masashi; Sata, Masataka

doi:10.1186/1475-2891-13-112

Cited by 17 publications

(30 citation statements)

References 24 publications

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“…The levels of DHA, EPA and EPA/AA ratio found in our cohort were similar to those found in several other Japanese studies; however our cohort’s AA levels were higher in comparison [42, 43]. For example, in Yanagisawa et al’s study, the mean level of serum DHA was 123.2 ± 27.0 μg/ml, EPA was 81.9 ± 31.1 μg/ml, AA was 119.8 ± 22.7 μg/ml, and EPA/AA ratio was 0.68 ± 0.22 among those aged 65 and older.…”

Section: Discussionsupporting

confidence: 90%

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Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study

Nishihira

Tokashiki

Higashiuesato

et al. 2016

JAD

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Background Epidemiological studies have found frequent consumption of fatty fish is protective against cognitive decline. However, the association between circulating omega-3 polyunsaturated fatty acid (PUFA) levels and cognitive functions among the oldest old is not well known. Objective To examine the association between serum PUFA levels and cognitive function among community-dwelling, non-demented elderly aged over 80 years old. Methods The data came from the Keys to Optimal Cognitive Aging (KOCOA) study; an ongoing cohort of relatively healthy volunteers aged over 80 years old, living in Okinawa, Japan. One hundred eighty five participants (mean age 84.1 ± 3.4 years) assessed in 2011 who were free from frank dementia (defined as Clinical Dementia Rating < 1.0) were used for the current cross-sectional study. We examined whether serum omega-3 PUFAs (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]), arachidonic acid (AA), EPA/AA ratio, DHA/AA ratio and DHA+EPA are associated with (1) age and (2) global cognitive function (Japanese MMSE) and executive function (Verbal Fluency Letters). Data was analyzed univariately by t-test and multivariately by cumulative logistic regression models controlling for age, gender, years of education, obesity, hypertension, diabetes, and dyslipidemia. Results Serum DHA levels decreased with increasing age (p = 0.04). Higher global cognitive function was associated with higher levels of serum EPA (p = 0.03) and DHA + EPA (p = 0.03) after controlling for confounders. Conclusions Higher serum EPA and DHA + EPA levels were independently associated with better scores on global cognitive function among the oldest old, free from dementia. Longitudinal follow-up studies are warranted.

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Section: Discussionsupporting

confidence: 90%

“…Bowman et al [10, 43] found significant associations between executive function and DHA as well as EPA. We did not find any associations between EPA, DHA and executive function.…”

Section: Discussionmentioning

confidence: 99%

Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study

Nishihira

Tokashiki

Higashiuesato

et al. 2016

JAD

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“…Nonetheless, benefits for the brain that may have been conferred through the effects of EPA on peripheral and/or cerebral blood flow cannot be ruled out. 70 Similarly, the significant effects of diet on 18:2n -6, 22:4n -6, 22:5n -3, and 22:5n -6 are consistent with previous dietary work showing that omega-3 intake regulates the fatty acid desaturase system in a manner that results in these four fatty acids serving as precursor pools or less optimal replacements for arachidonic acid or DHA. 58,59,71,72 Indeed, it may be that alteration of the efficiency of the desaturase system by a singlenucleotide polymorphism may ultimately affect how well a human responds to DHA or omega-3 administration.…”

Section: Discussionsupporting

confidence: 88%

Selective Reduction of Brain Docosahexaenoic Acid after Experimental Brain Injury and Mitigation of Neuroinflammatory Outcomes with Dietary DHA

Butt¹,

Harrison

Rowe

et al. 2017

Curr Res Concussion

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Background Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is important for brain development and function, but the interactions of dietary DHA with fatty acid profiles, sensory sensitivities, and inflammation that may change after traumatic brain injury (TBI) are poorly understood. It is also unknown whether DHA alters experimental TBI outcomes measured more than 2 weeks after injury. The current study investigated whether dietary DHA, provided before (PreDHA) or after (PostDHA) experimental TBI, would improve outcomes for up to 24 days after injury. Methods Rats consumed predetermined diets for 28 days prior to midline fluid percussion injury (mFPI) or to sham surgery. The effects of PreDHA, TBI, and PostDHA on comprehensive fatty acid profiles, neuroinflammation, sensory sensitivity, and spatial learning were then evaluated. Results The results provided novel evidence that TBI selectively reduced brain DHA content, as injury did not decrease any other fatty acid that was measured. Furthermore, PreDHA and PostDHA attenuated injury-induced increases in sensory sensitivity as well as in tumor necrosis factor-α (TNF-α), interleukin-10, and interleukin-1β in the somatosensory cortex. However, [3 H]PK11195 autoradiography showed that PostDHA

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“…In patients with cardiovascular disease, low serum level of EPA and low EPA/AA ratio have been reported to serve as risk factors for cognitive impairment. 6 When taken together with the previous report of a significant association between the severity of leukoaraiosis and decreased cognitive functions, the results of the present study suggest that low serum EPA level will compromise the cognitive function mediated by WMH. 7,8 Furthermore, considering the report that a low serum EPA level is a risk factor for intracerebral hemorrhage, 9 and that the presence of WMH is also one of the risk factors for intracerebral hemorrhage, 10,11 it is assumed that low serum EPA is associated with greater WMH and serves as a risk factor for intracerebral hemorrhage.…”

Section: Discussionsupporting

confidence: 81%

“…In patients with cardiovascular disease, low serum level of EPA and low EPA/AA ratio have been reported to serve as risk factors for cognitive impairment . When taken together with the previous report of a significant association between the severity of leukoaraiosis and decreased cognitive functions, the results of the present study suggest that low serum EPA level will compromise the cognitive function mediated by WMH …”

Section: Discussionsupporting

confidence: 72%

Correlation between the serum eicosapentanoic acid‐to‐arachidonic acid ratio and the severity of cerebral white matter hyperintensities in older adults with memory disorder

Nagai

Koshiba

Shibata

et al. 2015

Geriatrics Gerontology Int

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Aim:The relationships of n-3 polyunsaturated fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid (EPA), to stroke and cardiovascular events have been studied extensively. The present study was undertaken to analyze the relationships of the severity of cerebral white matter hyperintensities (WMH) to the blood polyunsaturated fatty acids level and the ratio of serum EPA level to the serum arachidonic acid (AA) level (EPA/AA ratio) among older adults. Methods:A total of 150 patients underwent diagnostic magnetic resonance imaging and blood sampling under the fasting state. In regard to WMH, the periventricular hyperintensities and deep white matter hyperintensities were rated according to the Fazekas classification. The serum docosahexaenoic acid, EPA, AA, dihomo-γ-linolenic acid and EPA/AA ratio were compared in relation to the grade of severity of WMH. Furthermore, multiple regression analysis was carried out with age, sex and atherosclerosis risk factors (hypertension, diabetes mellitus, hyperlipidemia, smoking status) as the covariables, serum polyunsaturated fatty acids level as an independent variable and Fazekas grade as the dependent variable.Results: A rise of the periventricular hyperintensities grade was associated with a significant reduction of the mean EPA level (P < 0.05) and EPA/AA ratio (P < 0.05). The multiple regression analysis identified a significant negative correlation between the periventricular hyperintensities grade and the serum EPA/AA ratio (β = −0.215, P < 0.05). Conclusion:These results suggest that the serum EPA/AA ratio have an important role in the formation and progression of WMH. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 48-52.

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Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease

Cited by 17 publications

References 24 publications

Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study

Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study

Selective Reduction of Brain Docosahexaenoic Acid after Experimental Brain Injury and Mitigation of Neuroinflammatory Outcomes with Dietary DHA

Correlation between the serum eicosapentanoic acid‐to‐arachidonic acid ratio and the severity of cerebral white matter hyperintensities in older adults with memory disorder

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