Serum concentration of IL‐17, IL‐23 and TNF‐α among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test

Abstract

Our results showed high serum levels of IL-17, IL-23 and TNF-α among CSU patients which may highlight a functional role of these cytokines in the pathogenesis of this important and common skin disease. It also may provide the rationale for new treatment strategies in chronic urticaria.

Effects of omalizumab treatment on serum cytokine concentrations of atopic patients with chronic spontaneous urticaria: a preliminary report

“…Downregulation of high affinity IgE receptors (FceRI) on mast cells, as a consequence of circulating IgE Reports on cytokine serum levels in chronic spontaneous urticaria patients are not numerous in the literature. Most of the studies have emphasized the observation of elevated levels of proinflammatory cytokines and their relationship with disease severity (12)(13)(14). Conversely, scant evidence exists with regard to Th2-type cytokines (15).…”

“…Conversely, scant evidence exists with regard to Th2-type cytokines (15). In addition, only a few cytokines in a given patient population have been evaluated in the studies available in the literature (12)(13)(14)(15).…”

Urticária Crónica - Do Diagnóstico ao Tratamento

“…15 Dados recentes revelam um ambiente de citocinas que aponta para a ativação da resposta inata -IL-(interleucina)-33, IL-25 e TSLP (Thymic stromal lymphopoietin) -com desvio Th2 (IL-4, IL-5) 14 ou, nalguns casos, Th0, misto Th1/Th2 ou mesmo Th17. 16 A histamina é um dos mediadores mastocitários mais estudados, mas a frequente ineficácia dos anti-histamínicos H1 na UCE sugere a participação de outros mediadores pró-inflamatórios, nomeadamente PAF (platelet activating factor), prostagladinas, leucotrienos, CGRP (calcitonon-gene related peptide), citocinas e quimiocinas, como o VEGF, CCL-5/RANTES e o TNF-alfa, entre outros. Alguns destes mediadores estão aumentados no sangue periférico e em correlação com a atividade da urticária.…”

“…2). 16,20,21 Ainda, uma resposta imunológica inata ativada por agentes infecciosos (Helicobacter pylori), ou outros estímu-los, poderá ter efeito desgranulante do mastócito, 14 particularmente em indivíduos susceptíveis (e.g. polimorfismos nos genes da resposta imuno-inflamatória).…”

The ROLE OF CYTOKINES IL-4 AND TNFα IN THE PATHOGENESIS OF ACUTE URTICARIA

“…IL-4 стимулирует рост тучных клеток, индуцирует экспрессию высокоафинного рецептора IgE (FcεRI) на В-лимфоцитах человека. При связывании IgE с высокоафинными рецепторами FcεRI тучных клеток происходит их дегрануляция с высвобождением гистамина, гепарина, протеаз, образованием лейкотриенов, простогландинов, цитокинов, таких как TNFα и IL-1 (Сергеев, 2001;Atwa, 2014). Выброс биологически активных веществ вследствие дегрануляции способствует сокращению гладкой мускулатуры, повреждению сосудов, повышению их проницаемости, в результате чего развивается зуд и отек тканей (Paul, 2010).…”