Serum Concentration of Thyroid Hormones Long-Term After Sulfur Mustard Exposure

Abstract

Background: Despite several reports on the clinical manifestations of sulfur mustard (SM) intoxication, there is no study on serum concentrations of thyroid hormones long-term after SM exposure. In this study, the changes in thyroid functioning parameters 20 yr after SM exposure were evaluated.
 Methods: This study is a part of a larger historical cohort study conducted in 2007 following 20 years of the exposure to SM, called Sardasht–Iran cohort study (SICS). We (SICS) comprised an SM–exposed group from Sardasht City, West Azerbaijan Province, Iran (n=169 as hospitalized group and n=203 as non-hospitalized exposed group); and control participants were selected from Rabat, a town near Sardasht (n=126). Peripheral blood samples were taken in fasting state and then the sera were separated. T4, T3, TSH, antithyroglobulin (anti–Tg), and antithyroid peroxidase (anti–TPO) concentrations in the sera were measured by the ELISA method.
 Results: The mean of T3 concentration was significantly higher in the exposed than control group (0.88 ± 0.26 nmol/L vs 0.8 ± 0.25 nmol/L, P<0.001). The levels of TSH, T4, and T3up were not significantly different between the exposed and control groups. Thyroglobulin level was significantly higher in the exposed non-hospitalized group (56.07 ± 140.22 µg/L vs 17.66 ± 41.49 µg/L, P=0.004), but the level of anti–Tg and anti–TPO showed no significant differences between the two groups.
 Conclusion: More studies are needed on the alterations in thyroid hormones, their gene expressions, and mechanisms involved in SM exposure to clarify the causes of these alterations.

ReBiochemical and hematological findings of Halabja victims: 34 years after sulfur mustard exposure

“…Respiratory complications are the main cause of long-term disability among SM-exposed victims (28). Although the majority of thyroid tests were normal in our study without significant differences, whereas according to a recent study that has done in Sardasht-Iran for exposed cases with SM showed the mean only of T3 concentration was significantly higher in the exposed than the control group (29). In this study, a significant decrease was observed in the concentrations of serum albumin and total protein in the case group.…”

Cytological Grading of Lymphocytic Thyroiditis and Its Correlation With Biochemical Parameters: An Experience From a Tertiary Care Center in North India

“…Patients underwent clinical and biochemical evaluations. This included the estimation of thyroid hormones (T3, T4, and thyroid-stimulating hormone [TSH]), with normal ranges for T3, T4, and TSH set at 0.52-1.85 ng/ml for T3, 4.4-10.8 μg% for T4, and 0.4-6.1 μIU/ml for TSH, respectively [ 6 ].…”