Serum Concentrations of Alkaline Phosphatase Isoenzymes and Osteocalcin in Normal Pregnancy*

Rodin, A.; Duncan, A.; Quartero, H.W.P.; Pistofidis, George; Mashiter, G.; Whitaker, Katrine B.; Crook, David; Stevenson, JohnC.; Chapman, Michael; Fogelman, Ignac

doi:10.1210/jcem-68-6-1123

Cited by 95 publications

(46 citation statements)

References 4 publications

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“…The maternal serum Gla concentrations measured in peripheral blood drawn immediately before delivery were consistent with previous reports from both animal and human studies (25,26). The Gla concentrations were low.…”

Section: Resultssupporting

confidence: 89%

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

et al. 1992

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ABSTRAm. Serum osteocalcin (Gla) and skeletal alkaline phosphatase (SAP) concentration both reflect osteoblast activity in the dynamic process of bone formation. To assess the relation in premature infants between change in bone mineral content (BMC) and both Gla and SAP serum concentration, we longitudinally measured BMC via photon absorptiometry and serum Gla and SAP concentration from birth to 16 wk in 20 very low birth weight infants. Serum total calcium, phosphorus, parathyroid hormone, and vitamin D metabolite concentrations were also monitored.All serum values were measured in the 20 mothers at delivery. Cord blood Gla concentrations were significantly ( p < 0.03) greater than maternal levels, and by 1 wk had significantly ( p < 0.001) increased from birth values. Total calcium, parathyroid hormone, phosphorus, and vitamin D concentrations remained in the normal range throughout the study. The increase in serum Gla concentrations, birth to 1 wk, were significantly correlated with the simultaneous increase in 1,25-dihydroxyvitamin D concentrations. The correlation between the change in BMC, however, over the first 4 mo of life and both Gla and SAP serum concentrations failed to reach statistical significance. Finally, a significant ( p < 0.003) negative correlation was measured between serum Gla and SAP concentrations at wk 4, and, although not significant, a consistently negative correlation was measured from 1-16 wk of age. These data demonstrate a 1,25-dihydroxyvitamin D associated rise in neonatal serum Gla concentration during the 1st week after delivery, no significant correlation between the change in neonatal BMC over the first 4 mo of life and serum Gla or SAP concentration, and a consistent negative correlation between serum Gla and SAP concentrations. These data do not indicate that either serum Gla or SAP concentration is a reliable predictor for the change in bone mineral content of very low birth weight infants over the first 16 wk of life. (Pediatr Res 31: 181-185, 1992) Abbreviations Gla, osteocalcin SAP, skeletal alkaline phosphatase TAP, total alkaline phosphatase BMC, bone mineral content VLBW, very low birth weight (

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Section: Resultssupporting

confidence: 89%

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

et al. 1992

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“…The possibility that the postpartum increase in ICTP may reflect degradation of uterine collagen due to uterine involution should be considered,but the effect of uterine involution on postpartum ICTP levels may be small,since the postpartum levels of PICP,a type I collagen-related protein the same as ICTP,were not significantly different from the prepartum level.Prepartum BGP was low or undetectable.This finding is basically in agreement with the results of previous studies [28,29].The disappearance of serum BGP during pregnancy has been speculated to be attributable to trapping or destruction of BGP by the placenta [29]. Postpartum,BGP gradually increased and was maintained at a high level from one month postpartum to the end of the study.The continued increase in postpartum BGP is in agreement with earlier reports [1,3]and suggests a high degree of bone formation during this period.Although the time courses of these markers were essentially the same in both groups up to 3 months postpartum, between-group differences in the serum markers were observed at 9 months.PICP and ICTP decreased to the control values in the short-term group,but higher levels than the control were maintained in the long-term group.The BGP level in the short-term group was also significantly lower than that in the long-term group.These biochemical findings were consistent with the significant decrease in lumbar BMD seen at 3 months postpartum in both groups and with the recovery of lumbar BMD at 9 months postpartum in the short-term group.…”

Section: Discussionsupporting

confidence: 93%

Bone Metabolism after Human Parturition and the Effect of Lachtion: Longitudinal Analysis of Serum Bone-Related Proteins and Bone Mineral Content of the Lumbar Spine.

et al. 1998

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Abstract.A prospective study was performed to investigate postpartum changes in human bone metabolism and the effects of lactation on them. The subjects consisted of two groups: 13 women who stopped breast-feeding within 3 months postpartum (short-term group) and 14 women who continued breast-feeding for more than 6 months postpartum (long-term group). Serum carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP), and bone gla protein (BGP) were measured prepartum, and at 5 days, 1 month, 3 months and 9 months postpartum.Lumbar BMD was measured at 3-7 days, 3 months and 9 months postpartum. Between prepartum and 3 months postpartum, the values and variations in the markers were essentially the same in both groups. PICP was maintained at a constant and significantly higher level than the control value. In contrast, ICTP had increased markedly at 5 days postpartum, gradually decreasing thereafter. BGP was low prepartum and gradually increased. At 9 months postpartum, PICP and ICTP decreased to the control values in the short-term group. The postpartum time course of lumbar BMD showed a significant decrease in both groups at 3 months postpartum. Recovery to the puerperal level was seen at 9 months postpartum in the short-term group but not in the long-term group. In conclusion, bone resorption is stimulated by parturition as well as lactation resulting in postpartum loss of lumbar BMD.Key words: Bone mineral content, Postpartum, Lactation, Propeptide of type I procollagen (PICP), Telopeptide of type I collagen (ICTP) (Endocrine Journal 45: 679-686, 1998) RECENT studies have shown decreased mineral content of trabecular bones in lactating women [1][2][3][4][5]. These lines of evidence are consistent with the results of several animal studies which have shown mineral loss in the trabecular bones of lactating animals [6,7] mineral content at the time of the examination does not reflect the actual status of bone metabolism at that time, but rather the outcome of past bone turnover. Anatomical and physiological changes in women are extensive and profound during the short span of human pregnancy and puerperium. It is therefore difficult to follow the changes in bone metabolism that occur during a relatively brief period, such as the puerperium, by using an image generation technique alone. A panel of biological markers of bone metabolism that could be measured in blood or urine would enable the status of bone at any given time to be clarified, and would thus be useful as a complement to DXA measurement.Recently, several promising bone-specific proteins which might serve as biological markers of bone turnover have been purified, and reliable assay systems for these proteins have been developed. These potential markers include the carboxyl-terminal propeptide of type I procollagen (PICP), carboxyl terminal cross-linked telopeptide of type I collagen (ICTP), and bone gla protein (BGP). PICP reflects the rate of formation of type I collagen, the main ...

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“…Biomar (n=17) ker levels in maternal and fetal circulation Table 3. Serum biomarker levels in male and female fetuses ly possibility is that the placenta is trapping or destroying osteocalcin [17], this being supported by the finding that a rapid increase in serum osteocalcin occurs after delivery [17,18].…”

Section: Discussionmentioning

confidence: 94%

Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation.

Yasumizu

Kato

1996

Endocr J

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Serum Concentrations of Alkaline Phosphatase Isoenzymes and Osteocalcin in Normal Pregnancy*

Cited by 95 publications

References 4 publications

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

Bone Metabolism after Human Parturition and the Effect of Lachtion: Longitudinal Analysis of Serum Bone-Related Proteins and Bone Mineral Content of the Lumbar Spine.

Concentrations of Serum Markers of Type I Collagen Synthesis and Degradation and Serum Osteocalcin in Maternal and Umbilical Circulation.

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